IGF-1 PGE2 osteo

[Guest guest]

Worthy of note.

{CRers report lower IGF-1 as I recall.}

Larsen: Textbook of Endocrinology, 10th ed.,

Insulin-like Growth Factors

IGFs increase bone cell replication, matrix synthesis, and bone formation.[52] Both IGF-I and IGF-II are synthesized by bone cells and stored in bone matrix. More IGF-II is stored in human bone, but IGF-I is a more potent stimulator of osteoblasts. Binding of IGF-I and IGF-II to matrix may be mediated by specific IGF-binding proteins. Five of the six known binding proteins have been identified in bone, and these both inhibit and enhance IGF responses. Because PTH and PGE2 increase and glucocorticoids decrease skeletal IGF-I synthesis, IGFs may mediate the effects of these hormones on bone growth. IGF-I and its binding proteins may also stimulate osteoclast formation.[53] [54]

53. Hill PA, Reynolds JJ, Meikle MC. Osteoblasts mediate insulin-like growth factor I and II stimulation of osteoclast formation and function. Endocrinology 1995; 136:124–131. 54. Kanatani M, Sugimoto T, Nishiyama K, et al. Stimulatory effect of insulin-like growth factor binding protein-5 on mouse osteoclast formation and osteoclastic bone-resorbing activity. J Bone Miner Res 2000; 15:902–910.

If I interpret that correctly, the IGF-1 in milk, if I can absorb it may be anti osteoporosis? Notice that PGE2 increases skeletal IGF-1 synthesis.

Regards.