cancer and ketogenic diet

[Guest guest]

There's hardly any info I could find about cancer and ketogenic diet but it's

primarily positive.

Chris

J Am Diet Assoc. 1995 Jun;95(6):693-7. <A

HREF= " http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Display & dopt=p\

ubmed_pubmed & from_uid=7759747 " >Related Articles,</A> >Links</A>

Implementing a ketogenic diet based on medium-chain triglyceride oil in

pediatric patients with cancer.

Nebeling LC, Lerner E.

Nutrition Department, Case Western Reserve University, Cleveland, Ohio

44106-4906, USA.

Traditionally, a ketogenic diet is given to drug-resistant children with

epilepsy to improve seizure control. Inducing a ketogenic state in patients with

cancer may be a useful adjunct to cancer treatment by affecting tumor glucose

metabolism and growth while maintaining the patient's nutritional status. A

ketogenic diet consisting of 60% medium-chain triglyceride (MCT) oil, 20%

protein, 10% carbohydrate, and 10% other dietary fats was provided to a select

group

of pediatric patients with advanced-stage cancer to test the effects of

dietary-induced ketosis on tumor glucose metabolism. Issues of tolerance and

compliance for patients consuming an oral diet (consisting of normal table foods

and

daily MCT oil " shakes " ) and for patients receiving an enteral formula are

reviewed. Preliminary use of the MCT oil-based diet suggests a potential in

pediatric patients with cancer.

Publication Types:

Review

Review, Tutorial

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J Am Coll Nutr. 1995 Apr;14(2):202-8. <A

HREF= " http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Display & dopt=p\

ubmed_pubmed & from_uid=7790697 " >Related Articles,</A> >Links</A>

Effects of a ketogenic diet on tumor metabolism and nutritional status in

pediatric oncology patients: two case reports.

Nebeling LC, Miraldi F, Shurin SB, Lerner E.

Nutrition Department, Case Western Reserve University, School of Medicine,

Cleveland, Ohio, USA.

OBJECTIVE: Establish dietary-induced ketosis in pediatric oncology patients

to determine if a ketogenic state would decrease glucose availability to

certain tumors, thereby potentially impairing tumor metabolism without adversely

affecting the patient's overall nutritional status. DESIGN: Case report.

SETTING:

University Hospitals of Cleveland. SUBJECTS: Two female pediatric patients

with advanced stage malignant Astrocytoma tumors. INTERVENTIONS: Patients were

followed as outpatients for 8 weeks. Ketosis was maintained by consuming a 60%

medium chain triglyceride oil-based diet. MAIN OUTCOME MEASURES: Tumor glucose

metabolism was assessed by Positron Emission Tomography (PET), comparing

[Fluorine-18] 2-deoxy-2-fluoro-D-glucose (FDG) uptake at the tumor site before

and

following the trial period. RESULTS: Within 7 days of initiating the

ketogenic diet, blood glucose levels declined to low-normal levels and blood

ketones

were elevated twenty to thirty fold. Results of PET scans indicated a 21.8%

average decrease in glucose uptake at the tumor site in both subjects. One

patient exhibited significant clinical improvements in mood and new skill

development during the study. She continued the ketogenic diet for an additional

twelve

months, remaining free of disease progression. CONCLUSION: While this diet

does not replace conventional antineoplastic treatments, these preliminary

results suggest a potential for clinical application which merits further

research.

PMID: 7790697 [PubMed - indexed for MEDLINE]

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