lectins and gluten sensitivity (was Candida connection)

[Guest guest]

>>>> Try doing a

search on " gliadin glucosamine " . Or click on the link below ...

http://bmj.com/cgi/content/full/318/7190/1023

----->oh yeh! i think i've read this, and now that i think about it, i think

we've had this glucosamine/lectin conversation before - on beyondprice last

year or thereabouts.

>>>>This is no academic question because diet is one part of the environment

that is manipulable and because lectins have excellent antidotes, at least

in vitro. Because of their precise carbohydrate specificities, lectins can

be blocked by simple sugars and oligosaccharides. Wheat lectin, for

example, is blocked by the sugar N-acetyl glucosamine and its polymers.5

---> i wonder if FOS (fructo *oligosaccharides) block any harmfulf lectins,

and if so, if that could be part of it's reported benefits to gut health?

>>>>Wheat gliadin, which causes coeliac disease, contains a lectin like

substance that binds to human intestinal mucosa,6 and this has been debated

as the " coeliac disease toxin " for over 20 years. "

---->i think this may (in part) address chris' question of HOW gliadin

damages intestinal walls. on the same subject from krispin sullivan

(http://www.krispin.com/lectin.html#Plain%20English):

" Common features of toxic (non-nutritive) effects in lectin-gut

interactions.

....Binding to brush border cells; damage to microvillus membrane; shedding

of cells; reduction in the absorptive capacity of the small intestine.

....Increased endocytosis; induction of hyperplastic grwoth of the small

intestine; increased turnover of epithelial cells. "

and

" Lectins may bind to the gut wall and damage the gut lining, are not altered

by digestive enzymes, and may alter gut permeability and pass through the

gut into general circulation.

Lectins can cause alterations in gut function that may be related to

colitis, Crohn's Disease, Celiac-Sprue, IBS and gut permeability.

Lectin damage to the gut wall may allow other non-lectin proteins to cross

undigested into general circulation and cause allergic reactions, including

anaphylaxis. "

also, here's an interesting excerpt on lectins/celiacs/gluten senstivity and

SCD:

" Historically diagnosis and treatment of Celiac-Sprue related to 'gliadin'

(also known as gluten) sensitivity. Gliadin is found in wheat, rye, barley,

oats, and foods containing these grains (including beer, grain based

alcohols, mayonnaise, grain vinegar, etc). Some Celiacs did not respond to

elimination of gluten/gliadin. In 1951 Drs. Sidney V. and Merrill P. Haas

published Management of Celiac Disease documenting treatment and cure of

celiac and cystic fibrosis of the pancreas with a carbohydrate limiting diet

introduced as the 'Specific Carbohydrate Diet'. More information about this

diet can be gotten from Breaking the Vicious Cycle E Gottschall, BA, MSc.

Kirkton Press Ltd. Baltimore, Ontario, Canada 1998.

In many cases cited in the book, elimination of certain carbohydrates

'cured' diagnosed Celiacs after one year and they were able to return to

eating gluten containing foods. In hindsight many of the foods eliminated in

this plan are high lectin foods known to be associated with gut and systemic

inflammatory reactions. Celiac-Sprue is a genetic disorder treated by

elimination of offending foods. The response of some to the specific

carbohydrate elimination diet would mean that the patients who responded did

not have classical gluten intolerance, Celiac-Sprue, which requires life

long elimination of gluten/gliadin. It suggests that other lectins may cause

similar symptoms and overlapping diagnostic and treatment difficulties.

If all cases of lectin intolerance were genetically based reversal of

intolerance would not be possible. There must therefore be a subgroup of

IBS, Crohn's, Celiac, colitis that is related to sensitization to food

lectins that can be reversed by avoidance of these lectins and a restoration

of gut function including SIgA and other immune protectors. Bacteria, virus,

or other conditions, drugs or injurious substances acting directly on the

gut wall may cause sensitization. "

Suze Fisher

Lapdog Design, Inc.

Web Design & Development

http://members.bellatlantic.net/~vze3shjg/

mailto:s.fisher22@...