Candida connection

[Guest guest]

This is extremely significant, I think! It might explain Gottschall's

observations (and Lutz's) a lot, if I'm reading this right. If a person is

sensitive to gliadin, then they would ALSO react to candida, even if they

were on a completely GF diet, because the protein strings are the same.

(And maybe react to some other yeasts as well?).

Celiac researchers have often thought that there must be a " trigger " to

start the IgA reaction (the person also has to have the right genes, but

not all people who have the genes react strongly to gluten). Mostly they

have thought it must be some virus though. Candida would seem to be a

better candidate!

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Is Candida albicans a trigger in the onset of coeliac disease?

Nieuwenhuizen WF, Pieters R, Knippels L, Jansen M, Koppelman SJ.

Netherlands Organisation for Applied Scientific Research (TNO) Nutrition

and Food Research, PO Box 360, 3700 AJ, Zeist, Netherlands

Coeliac disease is a T-cell-mediated autoimmune disease of the small

intestine that is induced by ingestion of gluten proteins from wheat,

barley, or rye. We postulate that Candida albicans is a trigger in the

onset of coeliac disease. The virulence factor of C albicans-hyphal wall

protein 1 (HWP1)-contains aminoacid sequences that are identical or highly

homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin

T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C

albicans to adhere to the intestinal epithelium. Furthermore, tissue

transglutaminase and endomysium components could become covalently linked

to the yeast. Subsequently, C albicans might function as an adjuvant that

stimulates antibody formation against HWP1 and gluten, and formation of

autoreactive antibodies against tissue transglutaminase and endomysium.

-- Heidi