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the answer for angular cheilitis associated with denture stomatitis but resistant to Nystatin is Miconazole gel. the reason is angular cheilitis can be caused either by candida which is a commensal of the oral cavity or by Staphylococcus aureus which resides in the nasal cavity(at the entrance). So a possible cause for angular cheilitis could be this S. aureus which responds well to fusidic acid powders and miconazole gel. Miconazole gel can act against both candida and S.aureus. hope this helps

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