UK: Co admin of HIB, Prevnar, Men C and MMR vaccine at 1 year

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Tragic.......................followed for 7

days......................sick! E (elizabeth) who never met

a vaccine she didn't like

Sheri

http://www.unboundmedicine.com/medline/ebm/record/21191076/abstract/Safety_and_immunogenicity_of_co_administering_a_combined_meningococcal_serogroup_C_and_Haemophilus_influenzae_type_b_conjugate_vaccine_with_7_valent_pneumococcal_conjugate_vaccine_and_measles_mumps_and_rubella_vaccine_at_12_months_of_age

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E, s N, Waight P, Findlow H, Ashton L, England A, Stanford

E, Matheson M, Southern J, Sheasby E, Goldblatt D, Borrow R

Safety and immunogenicity of co-administering a combined meningococcal

serogroup C and Haemophilus influenzae type b conjugate vaccine with

7-valent pneumococcal conjugate vaccine and measles, mumps and rubella

vaccine at 12 months of age. [JOURNAL ARTICLE]

Clin Vaccine Immunol 2010 Dec 29.

The coadministration of the combined meningococcal serogroup C conjugate

(MCC)/Haemophilus influenzae type b (Hib) vaccine with pneumococcal

conjugate vaccine (PCV7) and measles, mumps and rubella (MMR) vaccine at

12 months of age was investigated to assess the safety and immunogenicity

of this regimen compared with separate administration of the conjugate

vaccines. Children were randomized to receive MCC/Hib alone followed one

month later by PCV7 with MMR or to receive all three vaccines

concomitantly. Immunogenicity endpoints were MCC serum bactericidal

antibody (SBA) titers 8, Hib-polyribosylribitol phosphate (PRP) IgG

antibodies concentrations 0.15 g/mL, PCV serotype-specific IgG

concentrations 0.35 g/mL, measles and mumps IgG >120 AU/mL and rubella

IgG 11 AU/mL. For safety, proportions of children with erythema, swelling

or tenderness at site of injection, or fever or other systemic symptoms

for 7 days after immunization were compared between regimens. No adverse

consequences for either safety or immunogenicity were demonstrated when

MCC/Hib was given concomitantly with PCV and MMR at 12 months of age or

separately at 12 and 13 months of age. Any small differences in

immunogenicity were largely in the direction of a higher response when

all three vaccines were given concomitantly. For systemic symptoms, there

was no evidence of an additive effect, rather any differences between

schedules showed benefit from the concomitant administration of all three

vaccines, such as lower overall proportions with post-vaccination fevers.

The UK infant immunization schedule now recommends these three vaccines

may be offered at one visit between 12 to 13 months of age.

Sheri Nakken, R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Washington State, USA

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