Anti-obesity vaccine developed...or is it?

[Guest guest]

Read this shocker of a quote and then read the article and think - aren't we already doing this with vaccination? Wouldn't this explain so many of the truly severe autoimmune reactions we see following vaccination for which the link to vaccines is always denied?*******************************"This is an important proof of principle but there are problems. For example if you develop antibodies against something you can't get rid of them very easily, so if there's anything bad you can't undo it."And since ghrelin is present in the brain you might start an immune system response against the brain. It's not necessarily a very safe thing to do - I wouldn't want to be a volunteer."BBC NEWS | Health | 'Anti-obesity vaccine' developed

Many treatments for obesity have so far proved unsuccessful

http://news.bbc.co.uk/2/hi/health/5232150.stmUS researchers have developed a vaccine which prevents weight gain in rats, offering clues about human treatments.

The vaccine prompts the body to produce antibodies against ghrelin, a hormone that stimulates hunger and weight gain.

Vaccinated rats put on less weight while eating the same amount as those which did not have the jab.

A UK obesity expert said the Proceedings of the National Academy

of Sciences study was interesting, but it might not be safe for people.

Researchers at the Scripps Research Institute in California

developed three synthetic vaccines that recognise different parts of

the ghrelin hormone.

When injected into rats, two of the vaccines were found to bind

to the active form of ghrelin, inducing antibodies against the hormone

and blocking its action.

The vaccinated rats gained less body weight - specifically body

fat - and the reduction was associated with the levels of antibody

present.

The reduction in weight gain occurred despite the rats eating and

drinking normally, indicating that the inhibition of ghrelin was having

an effect on the animals' metabolism.

The researchers said the results demonstrated that active

immunisation against ghrelin could be used to control weight gain and

accumulation of fat tissue in mammals.

Study leader Professor Kim Janda said: "We believe that the

active form of ghrelin is what we are blocking but we can't say for

certain that's the only effect.

"Ghrelin slows down the metabolism so the vaccine is affecting that and also fat storage. This is a promising bit of science."

Human vaccine

Professor Janda said the ultimate goal was to develop a vaccine

to promote weight loss in humans although it may not be an active

vaccine because it is more difficult to control.

"Whether active immunisation against ghrelin would help prevent

the development of obesity because of energy-dense, palatable, high-fat

Western diets or would facilitate weight loss once obesity is

established is uncertain," he added.

Professor Bloom, professor of investigative science at

Imperial College London, said big pharmaceutical companies had been

looking for ways to block the action of ghrelin for years but it had

not yet proved effective.

"What is surprising about this study is that by producing antibodies to block ghrelin it works as well as it does.

"This is an important proof of principle but there are problems.

For example if you develop antibodies against something you can't get

rid of them very easily, so if there's anything bad you can't undo it.

"And since ghrelin is present in the brain you might start an

immune system response against the brain. It's not necessarily a very

safe thing to do - I wouldn't want to be a volunteer."

But he added: "Maybe we can find a safer way do to it and in that way the study is useful."

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