oldie: Gait disturbance interpreted as cerebellar ataxia after MMR vaccination at 15 months of age: a follow-up study.

[Guest guest]

anyone have the full thing?

Sheri

From: Binstock <binstock@...>

Continuing to read and re-read many of Andy's papers. Andy

& colleagues' reviews were excellent and passed peer-reviews. Here's

a tydbyt calling attention to more-severe subgroups.

- - - -

.. Gait disturbance interpreted

as cerebellar ataxia after MMR vaccination at 15 months of age: a

follow-up study.

Plesner AM, Hansen FJ, Taudorf K, Nielsen LH,

Larsen CB, Pedersen E.

Department of Epidemiology, Statens Serum Institute, Copenhagen,

Denmark.

Acta Paediatr. 2000 Jan;89(1):58-63.

http://www3.interscience.wiley.com/cgi-bin/fulltext/119933045/PDFSTART

Measles, mumps and rubella (MMR) vaccination was included in the Danish

childhood vaccination programme in 1987. During the following 10-y

period, 550 notification records of adverse events after MMR vaccination

at 15 mo of age have been registered, and a total of 41 notifications

have included " gait disturbance " . This corresponds to a

frequency of 8 per 100,000 doses of MMR vaccine used for 15-mo-old

children. The symptoms and signs are characteristic of cerebellar ataxia.

In 28 notifications, the descriptions by the doctors included only

" gait disturbance " , while in 13 an additional interpretation

was included. Thirty-two parents (78%) filled in a questionnaire and 26

(63%) agreed to participate in a clinical follow-up study. The gait

disturbance symptoms mainly occurred 7-14 d after the vaccination, and

the duration was median 1-2 wk (range 1 d to more than 4 mo).

One-third of the children had

symptoms lasting more than 2 wk. Significantly more children with long

duration of symptoms had some kind of complaint or clinical signs at the

follow-up in 1997. Gait disturbance registered after MMR vaccination

seems to be more frequent than hitherto reported. Most cases are mild and

short-lasting and a longer duration of symptoms seems to be predictive of

late sequelae. A clinical diagnosis of

cerebellar ataxia after MMR and the exact frequency of this adverse event

remains to be tested in prospective studies.

Sheri Nakken, R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Washington State, USA

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