Autoimmunity caused by over-stimulating the host’s immune ‘system’ by repeated immunization with antigen

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Self-Organized Criticality Theory of Autoimmunity

By PLoS ONE • on

December 31, 2009

Background

The cause of autoimmunity, which is unknown, is investigated from a

different angle, i.e., the defect in immune ‘system’, to explain the

cause of autoimmunity.

Methodology/Principal Findings

Repeated immunization with

antigen causes systemic autoimmunity in

mice otherwise not prone to spontaneous

autoimmune diseases. Overstimulation of

CD4+ T cells led to the

development of autoantibody-inducing

CD4+ T (aiCD4+ T) cell which had undergone T

cell receptor (TCR) revision and was capable of inducing autoantibodies.

The aiCD4+ T cell was induced by de novo TCR

revision but not by cross-reaction, and subsequently overstimulated

CD8+ T cells, driving them to become antigen-specific

cytotoxic T lymphocytes (CTL). These CTLs could be further matured by

antigen cross-presentation, after which they caused autoimmune tissue

injury akin to systemic lupus

erythematosus (SLE).

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of

over-stimulating the host’s immune ‘system’ by repeated immunization with

antigen, to the levels that surpass system’s self-organized

criticality.

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Self-Organized Criticality Theory of Autoimmunity

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Sheri Nakken, R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Washington State, USA

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