Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 Yes, and then there is Rhett's Syndrome from Asprin. You probably can " out every medication " with some side effect. - Not everyone is skilled at homepathic medicine - or have a practioner to consult with on a local level. But it would be wonderful if we all understood homepathic better and how to use it correctly. In EOHarm , Sheri Nakken <vaccineinfo@...> wrote: > > > >From: Binstock <binstock@...> > > > The PubMed search > ibuprofen AND stevens AND johnson > generated 7 citations (1-7). > > > > Lynne Arnold wrote: > Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side > Effects > > > Is there any difference between Motrin and generic ibuprofen? Because the > suit seems to be specifically about Motrin. Is that because this company > originated ibuprofen? > > Lynne > > ibuprofen AND stevens AND johnson > > 1: J Pediatr. 2004 Aug;145(2):273-6. > > Acute vanishing bile duct syndrome after ibuprofen therapy in a child. > > Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E. > > Pediatric Unit, Vesoul Hospital, Vesoul, France. > > We report the case of a 10 year-old girl who had s- syndrome and > cholestasis after ibuprofen therapy. Liver histology was compatible with > vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver > tests > normalized within 7 months. This report confirms that ibuprofen may induce > acute > vanishing bile duct syndrome. > > Publication Types: > Case Reports > Review > Review of Reported Cases > > PMID: 15289784 [PubMed - indexed for MEDLINE] > > > > 2: Dig Dis Sci. 2001 Nov;46(11):2385-8. > > s- Syndrome and cholestatic hepatitis. > > Morelli MS, O'Brien FX. > > Department of Internal Medicine, Section of General Internal Medicine, Wake > Forest University School of Medicine, Winston-Salem, North Carolina 27157, > USA. > > s- Syndrome (SJS) is a rare but severe dermatological condition > that typically occurs after the ingestion of medications such as nonsteroidal > drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the > syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, > gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, > which may precede the skin manifestations of SJS, has been reported to > occur in > SJS, but the medical literature has only 10 case reports describing this > phenomenon (1-9). We report the case of a 19-year-old female with SJS and > cholestatic liver disease. A discussion of the underlying pathophysiology > of SJS > and its treatment follows. > > Publication Types: > Case Reports > Review > Review of Reported Cases > > PMID: 11713940 [PubMed - indexed for MEDLINE] > > > > 3: Int J Dermatol. 1999 Nov;38(11):878-9. > > Pentoxyfylline in toxic epidermal necrolysis and s- syndrome. > > Sanclemente G, De la Roche CA, Escobar CE, Falabella R. > > Publication Types: > Case Reports > Letter > > PMID: 10583942 [PubMed - indexed for MEDLINE] > > > > 4: Int J Dermatol. 1998 Nov;37(11):833-8. > > Drugs causing fixed eruptions: a study of 450 cases. > > Mahboob A, Haroon TS. > > Department of Dermatology, King Medical College/Mayo Hospital, Lahore, > Pakistan. > > BACKGROUND: Drug eruptions are among the most common cutaneous disorders > encountered by the dermatologist. Some drug eruptions, although trivial, may > cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The > diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE: > We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The > ratio of men to women was 1:1.1. The main presentation of FDE was circular > hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema, > urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally > FDE mimicked lichen planus, erythema multiforme, s- syndrome, > paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen > planus > actinicus, discoid lupus erythematosus, erythema annulare centrifugum, > pemphigus > vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis. > Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were > tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid, > mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, > ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac > sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, > allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the > most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel > pamoate, > clindamycin, and albendazole were reported for the first time. FDE may have > multiform presentations. > > PMID: 9865869 [PubMed - indexed for MEDLINE] > > > > 5: Gastroenterology. 1998 Sep;115(3):743-6. > > Drug-associated acute-onset vanishing bile duct and s- > syndromes in > a child. > > Srivastava M, -Atayde A, Jonas MM. > > Combined Program in Gastroenterology, Department of Medicine, Children's > Hospital, Boston, Massachusetts, USA. > > Acute vanishing bile duct syndrome is a rare but established cause of > progressive cholestasis in adults, is most often drug or toxin related, and is > of unknown pathogenesis. It has not been reported previously in children. > s- syndrome is a well-recognized immune complex- mediated > hypersensitivity reaction that affects all age groups, is drug or infection > induced, and has classic systemic, mucosal, and dermatologic manifestations. A > previously healthy child who developed acute, severe, rapidly progressive > vanishing bile duct syndrome shortly after s- syndrome is > described; this was temporally associated with ibuprofen use. Despite therapy > with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic > disease was unrelenting, with cirrhosis shown by biopsy 6 months after > presentation. This case documents acute drug-related vanishing bile duct > syndrome in the pediatric age group and suggests shared immune mechanisms > in the > pathogenesis of both s- syndrome and vanishing bile duct > syndrome. > > Publication Types: > Case Reports > > PMID: 9721172 [PubMed - indexed for MEDLINE] > > > > 6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76. > > Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review. > > Bigby M, Stern R. > > The nonsteroidal anti-inflammatory drugs are one of the most commonly > prescribed > classes of drugs used in medical practice. This review discusses the diverse > cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. > Adverse cutaneous reactions occur most frequently with benoxaprofen, > piroxicam, > sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most > serious adverse cutaneous reactions, s- syndrome and toxic > epidermal necrolysis, appear to be most often associated with sulindac and > phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar > pyrrole > derivatives, have been associated with a disproportionate number of cases of > anaphylactoid reactions. Among the currently marketed nonsteroidal > anti-inflammatory drugs, piroxicam appears to have the highest rate of > phototoxic reactions. This phototoxic eruption is most often vesiculobullous. > > Publication Types: > Review > > PMID: 3159761 [PubMed - indexed for MEDLINE] > > > > 7: N Y State J Med. 1978 Jul;78(8):1239-43. > > s- syndrome plus toxic hepatitis due to ibuprofen. > > Sternlieb P, RM. > > Publication Types: > Case Reports > > PMID: 276660 [PubMed - indexed for MEDLINE] > > -------------------------------------------------- > > -------------------------------------------------------- > Sheri Nakken, R.N., MA, Hahnemannian Homeopath > Vaccination Information & Choice Network, Nevada City CA & Wales UK > $$ Donations to help in the work - accepted by Paypal account > earthmysteriestours@... voicemail US 530-740-0561 > (go to http://www.paypal.com) or by mail > Vaccines - http://www.nccn.net/~wwithin/vaccine.htm > Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm > Reality of the Diseases & Treatment - > http://www.nccn.net/~wwithin/vaccineclass.htm > Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 Sheri, I found this interesting. When my youngest had Aseptic meningitis as a result of his first IVIG infusion at the wrong rate, I looked up everything I could find on aseptic meningitis. I came across a few abstracts (posted below) linking a. meningitis to ibuprofin. Ironically, it is recommended that you premedicate with Tylenol or Motrin. I chose Motrin because I thought it was the lesser of two evils. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1306340 http://pmj.bmj.com/cgi/content/abstract/79/931/295 ADVERSE DRUG REACTION Recurrent aseptic meningitis due to different non-steroidal anti-inflammatory drugs including rofecoxib M L Ashwath and H P Katner Department of Internal Medicine, Mercer University School of Medicine, Macon, Georgia Correspondence to: Dr Ashwath; Mahi_Lakshmi@... ABSTRACT Aseptic meningitis can be caused by viruses, drugs, and connective tissue disorders. The most common drugs causing it include antibiotics like trimethoprim-sulfamethoxazole, non-steroidal anti-inflammatory drugs (NSAIDs), intravenous immunoglobulins, intrathecal agents, vaccines, and monoclonal antibodies. A patient who had aseptic meningitis from three different NSAIDs including rofecoxib is presented. Keywords: non-steroidal anti-inflammatory drugs; adverse drug reaction; rofecoxib Abbreviations: COX, cyclo-oxygenase; DIAM, drug induced aseptic meningitis; NSAIDs, non-steroidal anti-inflammatory drugs http://gateway.nlm.nih.gov/MeetingAbstracts/102201188.html Ibuprofen-induced aseptic meningitis in individuals with HIV. Perlman DM. Int Conf AIDS. 1992 Jul 19-24; 8: 119 (abstract no. PuB 7425). Univ. of Colorado Health Sciences Ctr, Denver. OBJECTIVES: To describe the clinical manifestations and epidemiology of aseptic meningitis caused by use of nonsteroidal anti-inflammatory drugs (NSAIDs) in HIV positive individuals. METHODS: Case studies are presented involving two patients that developed aseptic meningitis after use of NSAIDs. A retrospective analysis of use of NSAIDs in an HIV population was undertaken to determine the frequency of this phenomenon. RESULTS: This is the first description of aseptic meningitis developing in HIV positive individuals following NSAID ingestion, a condition previously described in association with autoimmune diseases such as lupus. One patient with this disorder relapsed after re- exposure to a NSAID. Despite the rarity of this disorder NSAID use in the HIV population was common with 35.4% of our patients using these agents over a 6 month period. CONCLUSIONS: Increased suspicion of the role of NSAIDs in aseptic meningitis in HIV- infected patients may lead to further recognition of this uncommon entity. Taking a thorough drug history can avoid exposure to a suspected NSAID and reduce the risk of recurrent aseptic meningitis. Further investigations are required to elucidate the role of polyclonal gammopathy and autoimmunity in the pathophysiology of this entity. Publication Types: Meeting Abstracts Keywords: AIDS Vaccines Acquired Immunodeficiency Syndrome Anti-Inflammatory Agents, Non-Steroidal HIV Infections HIV Seropositivity Humans Ibuprofen Meningitis, Aseptic Recurrence Other ID: 92403474 UI: 102201188 From Meeting Abstracts http://jpp.sagepub.com/cgi/content/abstract/19/2/113 Journal of Pharmacy Practice, Vol. 19, No. 2, 113-123 (2006) DOI: 10.1177/0897190006289981 © 2006 SAGE Publications Ibuprofen-Associated Aseptic Meningitis Joanna E. Meier P. , PharmD, BCPS University of Southern Nevada College of Pharmacy, 11 Sunset Way, , NV 89014 Aseptic meningitis is a rare condition associated with ibuprofen use. It is a diagnosis of exclusion and should be considered only after all infectious and most well-known noninfectious causes have been ruled out. The mechanism of ibuprofen-induced aseptic meningitis is not fully understood; however, most believe it is caused by a hypersensitivity-related reaction. Common symptoms of aseptic meningitis include headache, fever, nuchal rigidity, and confusion. Cerebral spinal fluid analysis generally reveals pleocytosis (the predominant white blood cell varies), with high protein concentrations and normal to low glucose concentrations. Autoimmune diseases and connective tissue diseases may predispose an individual to this condition. It is treated solely by withdrawal of the medication, although supportive treatment is often necessary. It is important that health care practitioners recognize this condition so that they are able to treat and prevent recurrence through patient education. Key Words: ibuprofen • aseptic meningitis • Motrin • Advil > Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side > Effects > > > Is there any difference between Motrin and generic ibuprofen? Because the > suit seems to be specifically about Motrin. Is that because this company > originated ibuprofen? > > Lynne > > ibuprofen AND stevens AND johnson > > 1: J Pediatr. 2004 Aug;145(2):273-6. > > Acute vanishing bile duct syndrome after ibuprofen therapy in a child. > > Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E. > > Pediatric Unit, Vesoul Hospital, Vesoul, France. > > We report the case of a 10 year-old girl who had s- syndrome and > cholestasis after ibuprofen therapy. Liver histology was compatible with > vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver > tests > normalized within 7 months. This report confirms that ibuprofen may induce > acute > vanishing bile duct syndrome. > > Publication Types: > Case Reports > Review > Review of Reported Cases > > PMID: 15289784 [PubMed - indexed for MEDLINE] > > > > 2: Dig Dis Sci. 2001 Nov;46(11):2385-8. > > s- Syndrome and cholestatic hepatitis. > > Morelli MS, O'Brien FX. > > Department of Internal Medicine, Section of General Internal Medicine, Wake > Forest University School of Medicine, Winston-Salem, North Carolina 27157, > USA. > > s- Syndrome (SJS) is a rare but severe dermatological condition > that typically occurs after the ingestion of medications such as nonsteroidal > drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the > syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, > gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, > which may precede the skin manifestations of SJS, has been reported to > occur in > SJS, but the medical literature has only 10 case reports describing this > phenomenon (1-9). We report the case of a 19-year-old female with SJS and > cholestatic liver disease. A discussion of the underlying pathophysiology > of SJS > and its treatment follows. > > Publication Types: > Case Reports > Review > Review of Reported Cases > > PMID: 11713940 [PubMed - indexed for MEDLINE] > > > > 3: Int J Dermatol. 1999 Nov;38(11):878-9. > > Pentoxyfylline in toxic epidermal necrolysis and s- syndrome. > > Sanclemente G, De la Roche CA, Escobar CE, Falabella R. > > Publication Types: > Case Reports > Letter > > PMID: 10583942 [PubMed - indexed for MEDLINE] > > > > 4: Int J Dermatol. 1998 Nov;37(11):833-8. > > Drugs causing fixed eruptions: a study of 450 cases. > > Mahboob A, Haroon TS. > > Department of Dermatology, King Medical College/Mayo Hospital, Lahore, > Pakistan. > > BACKGROUND: Drug eruptions are among the most common cutaneous disorders > encountered by the dermatologist. Some drug eruptions, although trivial, may > cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The > diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE: > We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The > ratio of men to women was 1:1.1. The main presentation of FDE was circular > hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema, > urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally > FDE mimicked lichen planus, erythema multiforme, s- syndrome, > paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen > planus > actinicus, discoid lupus erythematosus, erythema annulare centrifugum, > pemphigus > vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis. > Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were > tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid, > mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, > ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac > sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, > allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the > most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel > pamoate, > clindamycin, and albendazole were reported for the first time. FDE may have > multiform presentations. > > PMID: 9865869 [PubMed - indexed for MEDLINE] > > > > 5: Gastroenterology. 1998 Sep;115(3):743-6. > > Drug-associated acute-onset vanishing bile duct and s- > syndromes in > a child. > > Srivastava M, -Atayde A, Jonas MM. > > Combined Program in Gastroenterology, Department of Medicine, Children's > Hospital, Boston, Massachusetts, USA. > > Acute vanishing bile duct syndrome is a rare but established cause of > progressive cholestasis in adults, is most often drug or toxin related, and is > of unknown pathogenesis. It has not been reported previously in children. > s- syndrome is a well-recognized immune complex-mediated > hypersensitivity reaction that affects all age groups, is drug or infection > induced, and has classic systemic, mucosal, and dermatologic manifestations. A > previously healthy child who developed acute, severe, rapidly progressive > vanishing bile duct syndrome shortly after s- syndrome is > described; this was temporally associated with ibuprofen use. Despite therapy > with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic > disease was unrelenting, with cirrhosis shown by biopsy 6 months after > presentation. This case documents acute drug-related vanishing bile duct > syndrome in the pediatric age group and suggests shared immune mechanisms > in the > pathogenesis of both s- syndrome and vanishing bile duct > syndrome. > > Publication Types: > Case Reports > > PMID: 9721172 [PubMed - indexed for MEDLINE] > > > > 6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76. > > Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review. > > Bigby M, Stern R. > > The nonsteroidal anti-inflammatory drugs are one of the most commonly > prescribed > classes of drugs used in medical practice. This review discusses the diverse > cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. > Adverse cutaneous reactions occur most frequently with benoxaprofen, > piroxicam, > sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most > serious adverse cutaneous reactions, s- syndrome and toxic > epidermal necrolysis, appear to be most often associated with sulindac and > phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar > pyrrole > derivatives, have been associated with a disproportionate number of cases of > anaphylactoid reactions. Among the currently marketed nonsteroidal > anti-inflammatory drugs, piroxicam appears to have the highest rate of > phototoxic reactions. This phototoxic eruption is most often vesiculobullous. > > Publication Types: > Review > > PMID: 3159761 [PubMed - indexed for MEDLINE] > > > > 7: N Y State J Med. 1978 Jul;78(8):1239-43. > > s- syndrome plus toxic hepatitis due to ibuprofen. > > Sternlieb P, RM. > > Publication Types: > Case Reports > > PMID: 276660 [PubMed - indexed for MEDLINE] > > -------------------------------------------------- > > -------------------------------------------------------- > Sheri Nakken, R.N., MA, Hahnemannian Homeopath > Vaccination Information & Choice Network, Nevada City CA & Wales UK > $$ Donations to help in the work - accepted by Paypal account > earthmysteriestours@... voicemail US 530-740-0561 > (go to http://www.paypal.com) or by mail > Vaccines - http://www.nccn.net/~wwithin/vaccine.htm > Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm > Reality of the Diseases & Treatment - > http://www.nccn.net/~wwithin/vaccineclass.htm > Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 I think you meant Reyes syndrome. By the way, the other 50% of thimerosal is thiosalycylic acid. I think that is an ingredient in aspirin that may cause Reyes syndrome, no? Another vaccine danger? Heidi From: "s_degiusti" <blessingsx10@...>Reply-EOHarm To: EOHarm Subject: Re: s- Syndrome - ibuprofenDate: Sat, 23 Jun 2007 22:12:39 -0000 Yes, and then there is Rhett's Syndrome from Asprin.You probably can "out every medication" with some side effect. - Noteveryone is skilled at homepathic medicine - or have a practioner to consult with on a local level. But it would be wonderful if we all understood homepathic better and how to use it correctly. In Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 At 10:12 PM 6/23/2007 -0000, you wrote: >Yes, and then there is Rhett's Syndrome from Asprin. >You probably can " out every medication " with some side effect. - Not >everyone is skilled at homepathic medicine - or have a practioner to >consult with on a local level. But it would be wonderful if we all >understood homepathic better and how to use it correctly. Yes, Reye's syndrome, although that suddenly appeared in the 70's when I was first working in peds in hospital and that is what it was blamed on. But I have suspicions about it all. Tylenol was new at that time and got a big boast from aspirin being blamed - makes you wonder. Everyone in the 50's and 60's took aspirin when they were ill - measles, mumps, chickenpox and we didn't hear of any problems - including myself. But I need to look into it a little more before I can say for sure. Re: homeopathy - That's why I teach online classes so people can take charge themselves especially if there is no homeopath nearby and also share what I can on these lists Sheri > >In EOHarm , Sheri Nakken <vaccineinfo@...> wrote: >> >> >> >From: Binstock <binstock@...> >> >> >> The PubMed search >> ibuprofen AND stevens AND johnson >> generated 7 citations (1-7). >> >> >> >> Lynne Arnold wrote: >> Lawsuit Filed in Los Angeles Claims Children's Motrin Causes >Severe Side -------------------------------------------------------- Sheri Nakken, R.N., MA, Hahnemannian Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK $$ Donations to help in the work - accepted by Paypal account earthmysteriestours@... voicemail US 530-740-0561 (go to http://www.paypal.com) or by mail Vaccines - http://www.nccn.net/~wwithin/vaccine.htm Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm Reality of the Diseases & Treatment - http://www.nccn.net/~wwithin/vaccineclass.htm Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2007 Report Share Posted June 24, 2007 interesting. I think you are onto something. Sheri At 11:07 PM 6/23/2007 -0000, you wrote: >Sheri, I found this interesting. When my youngest had Aseptic meningitis as a result of his >first IVIG infusion at the wrong rate, I looked up everything I could find on aseptic >meningitis. I came across a few abstracts (posted below) linking a. meningitis to ibuprofin. >Ironically, it is recommended that you premedicate with Tylenol or Motrin. I chose Motrin >because I thought it was the lesser of two evils. > >http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1306340 > >http://pmj.bmj.com/cgi/content/abstract/79/931/295 > >ADVERSE DRUG REACTION > >Recurrent aseptic meningitis due to different non-steroidal anti-inflammatory drugs >including rofecoxib > >M L Ashwath and H P Katner >Department of Internal Medicine, Mercer University School of Medicine, Macon, Georgia > > >Correspondence to: >Dr Ashwath; >Mahi_Lakshmi@... > -------------------------------------------------------- Sheri Nakken, R.N., MA, Hahnemannian Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK $$ Donations to help in the work - accepted by Paypal account earthmysteriestours@... voicemail US 530-740-0561 (go to http://www.paypal.com) or by mail Vaccines - http://www.nccn.net/~wwithin/vaccine.htm Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm Reality of the Diseases & Treatment - http://www.nccn.net/~wwithin/vaccineclass.htm Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 17, 2007 Report Share Posted November 17, 2007 Duh- sorry, I just realized that you reposted from my June post. Talk about literal thinking, I thought you meant it was from a person NAMED June. I need more caffeine! LOL > > Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side > > Effects > > > > > > Is there any difference between Motrin and generic ibuprofen? Because the > > suit seems to be specifically about Motrin. Is that because this company > > originated ibuprofen? > > > > Lynne > > > > ibuprofen AND stevens AND johnson > > > > 1: J Pediatr. 2004 Aug;145(2):273-6. > > > > Acute vanishing bile duct syndrome after ibuprofen therapy in a child. > > > > Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E. > > > > Pediatric Unit, Vesoul Hospital, Vesoul, France. > > > > We report the case of a 10 year-old girl who had s- syndrome and > > cholestasis after ibuprofen therapy. Liver histology was compatible with > > vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver > > tests > > normalized within 7 months. This report confirms that ibuprofen may induce > > acute > > vanishing bile duct syndrome. > > > > Publication Types: > > Case Reports > > Review > > Review of Reported Cases > > > > PMID: 15289784 [PubMed - indexed for MEDLINE] > > > > > > > > 2: Dig Dis Sci. 2001 Nov;46(11):2385-8. > > > > s- Syndrome and cholestatic hepatitis. > > > > Morelli MS, O'Brien FX. > > > > Department of Internal Medicine, Section of General Internal Medicine, Wake > > Forest University School of Medicine, Winston-Salem, North Carolina 27157, > > USA. > > > > s- Syndrome (SJS) is a rare but severe dermatological condition > > that typically occurs after the ingestion of medications such as nonsteroidal > > drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the > > syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, > > gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, > > which may precede the skin manifestations of SJS, has been reported to > > occur in > > SJS, but the medical literature has only 10 case reports describing this > > phenomenon (1-9). We report the case of a 19-year-old female with SJS and > > cholestatic liver disease. A discussion of the underlying pathophysiology > > of SJS > > and its treatment follows. > > > > Publication Types: > > Case Reports > > Review > > Review of Reported Cases > > > > PMID: 11713940 [PubMed - indexed for MEDLINE] > > > > > > > > 3: Int J Dermatol. 1999 Nov;38(11):878-9. > > > > Pentoxyfylline in toxic epidermal necrolysis and s- syndrome. > > > > Sanclemente G, De la Roche CA, Escobar CE, Falabella R. > > > > Publication Types: > > Case Reports > > Letter > > > > PMID: 10583942 [PubMed - indexed for MEDLINE] > > > > > > > > 4: Int J Dermatol. 1998 Nov;37(11):833-8. > > > > Drugs causing fixed eruptions: a study of 450 cases. > > > > Mahboob A, Haroon TS. > > > > Department of Dermatology, King Medical College/Mayo Hospital, Lahore, > > Pakistan. > > > > BACKGROUND: Drug eruptions are among the most common cutaneous disorders > > encountered by the dermatologist. Some drug eruptions, although trivial, may > > cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The > > diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE: > > We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The > > ratio of men to women was 1:1.1. The main presentation of FDE was circular > > hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema, > > urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally > > FDE mimicked lichen planus, erythema multiforme, s- syndrome, > > paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen > > planus > > actinicus, discoid lupus erythematosus, erythema annulare centrifugum, > > pemphigus > > vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis. > > Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were > > tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid, > > mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, > > ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac > > sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, > > allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the > > most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel > > pamoate, > > clindamycin, and albendazole were reported for the first time. FDE may have > > multiform presentations. > > > > PMID: 9865869 [PubMed - indexed for MEDLINE] > > > > > > > > 5: Gastroenterology. 1998 Sep;115(3):743-6. > > > > Drug-associated acute-onset vanishing bile duct and s- > > syndromes in > > a child. > > > > Srivastava M, -Atayde A, Jonas MM. > > > > Combined Program in Gastroenterology, Department of Medicine, Children's > > Hospital, Boston, Massachusetts, USA. > > > > Acute vanishing bile duct syndrome is a rare but established cause of > > progressive cholestasis in adults, is most often drug or toxin related, and is > > of unknown pathogenesis. It has not been reported previously in children. > > s- syndrome is a well-recognized immune complex-mediated > > hypersensitivity reaction that affects all age groups, is drug or infection > > induced, and has classic systemic, mucosal, and dermatologic manifestations. A > > previously healthy child who developed acute, severe, rapidly progressive > > vanishing bile duct syndrome shortly after s- syndrome is > > described; this was temporally associated with ibuprofen use. Despite therapy > > with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic > > disease was unrelenting, with cirrhosis shown by biopsy 6 months after > > presentation. This case documents acute drug-related vanishing bile duct > > syndrome in the pediatric age group and suggests shared immune mechanisms > > in the > > pathogenesis of both s- syndrome and vanishing bile duct > > syndrome. > > > > Publication Types: > > Case Reports > > > > PMID: 9721172 [PubMed - indexed for MEDLINE] > > > > > > > > 6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76. > > > > Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review. > > > > Bigby M, Stern R. > > > > The nonsteroidal anti-inflammatory drugs are one of the most commonly > > prescribed > > classes of drugs used in medical practice. This review discusses the diverse > > cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. > > Adverse cutaneous reactions occur most frequently with benoxaprofen, > > piroxicam, > > sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most > > serious adverse cutaneous reactions, s- syndrome and toxic > > epidermal necrolysis, appear to be most often associated with sulindac and > > phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar > > pyrrole > > derivatives, have been associated with a disproportionate number of cases of > > anaphylactoid reactions. Among the currently marketed nonsteroidal > > anti-inflammatory drugs, piroxicam appears to have the highest rate of > > phototoxic reactions. This phototoxic eruption is most often vesiculobullous. > > > > Publication Types: > > Review > > > > PMID: 3159761 [PubMed - indexed for MEDLINE] > > > > > > > > 7: N Y State J Med. 1978 Jul;78(8):1239-43. > > > > s- syndrome plus toxic hepatitis due to ibuprofen. > > > > Sternlieb P, RM. > > > > Publication Types: > > Case Reports > > > > PMID: 276660 [PubMed - indexed for MEDLINE] > > > > -------------------------------------------------- > > > > -------------------------------------------------------- > > Sheri Nakken, R.N., MA, Hahnemannian Homeopath > > Vaccination Information & Choice Network, Nevada City CA & Wales UK > > $$ Donations to help in the work - accepted by Paypal account > > earthmysteriestours@ voicemail US 530-740-0561 > > (go to http://www.paypal.com) or by mail > > Vaccines - http://www.nccn.net/~wwithin/vaccine.htm > > Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm > > Reality of the Diseases & Treatment - > > http://www.nccn.net/~wwithin/vaccineclass.htm > > Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 17, 2007 Report Share Posted November 17, 2007 At 08:21 PM 11/17/2007 -0000, you wrote: >Duh- sorry, I just realized that you reposted from my June post. Talk about literal >thinking, I thought you meant it was from a person NAMED June. I need more caffeine! LOL That's what I figured out that you thought. Sheri > > >> >> Sheri, I found this interesting. When my youngest had Aseptic meningitis as a result of >his >> first IVIG infusion at the wrong rate, I looked up everything I could find on aseptic >> meningitis. I came across a few abstracts (posted below) linking a. meningitis to >ibuprofin. >> Ironically, it is recommended that you premedicate with Tylenol or Motrin. I chose >Motrin >> because I thought it was the lesser of two evils. >> >> http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1306340 >> >> http://pmj.bmj.com/cgi/content/abstract/79/931/295 >> -------------------------------------------------------- Sheri Nakken, former R.N., MA, Hahnemannian Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK $$ Donations to help in the work - accepted by Paypal account Voicemail US 530-740-0561 Vaccines - http://www.nccn.net/~wwithin/vaccine.htm or http://www.wellwithin1.com/vaccine.htm Vaccine Dangers On-Line courses - http://www.wellwithin1.com/vaccineclass.htm Reality of the Diseases & Treatment - http://www.nccn.net/~wwithin/vaccineclass.htm Homeopathy On-Line courses - http://www.wellwithin1.com/homeo.htm NEXT CLASSES start by email November 7 & 8 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2008 Report Share Posted March 29, 2008 Ugh. I became well versed in SJS when gavin started his Lamictal for seizures b/c it can be more common with the drug. His doctor made such a big deal about calling and stopping the meds if there is any rash... SO doesn't gavin get a rash... and the dumb doctor didn't return my call for 3 days. In the end the rash ended up being from Neosporin... but for a day I was worried I had just killed this poor kid all over again. --hmmmm... in some ways its easy to view our kids as frail, but did you ever step back and think of all the things that happened to them, and they came out of it ok, other than the autism? It's a weird thought, but one I ponder at times. My friends brother got SJS as a child, had a seizure, put on seizure meds, and that was that. To this day he is scarred all up, and has no finger nails. s- Syndrome - ibuprofen >From: Binstock <binstock@...> The PubMed search ibuprofen AND stevens AND johnson generated 7 citations (1-7). Lynne Arnold wrote: Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side Effects Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2008 Report Share Posted March 30, 2008 We need to be careful with the use of ibuprofen/Advil. According to my cousin, the "thrombo-team" who were involved with her daughter just over a year ago, when her daughter ended up hospitalised for cerca 6 weeks, after she received a meningitis shot while still having an ear infection, thought the blood clot that developed behind my cousin's daughter's left ear, was due to the Advil/ibuprofen she had had to kill the pain. I thought it was kind of amazing that these doctors would even be admitting that ibuprofen may be a factor in any of her problems at the time. Aasa Sheri Nakken <snakken@...> wrote: >From: Binstock <binstockpeakpeak>The PubMed searchibuprofen AND stevens AND johnsongenerated 7 citations (1-7).Lynne Arnold wrote:Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe SideEffectsIs there any difference between Motrin and generic ibuprofen? Because thesuit seems to be specifically about Motrin. Is that because this companyoriginated ibuprofen?Lynneibuprofen AND stevens AND johnson1: J Pediatr. 2004 Aug;145(2):273-6.Acute vanishing bile duct syndrome after ibuprofen therapy in a child.Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E.Pediatric Unit, Vesoul Hospital, Vesoul, France.We report the case of a 10 year-old girl who had s- syndrome andcholestasis after ibuprofen therapy. Liver histology was compatible withvanishing bile duct syndrome. She received ursodeoxycholic acid, and livertestsnormalized within 7 months. This report confirms that ibuprofen may induceacutevanishing bile duct syndrome.Publication Types:Case ReportsReviewReview of Reported CasesPMID: 15289784 [PubMed - indexed for MEDLINE]2: Dig Dis Sci. 2001 Nov;46(11):2385-8.s- Syndrome and cholestatic hepatitis.Morelli MS, O'Brien FX.Department of Internal Medicine, Section of General Internal Medicine, WakeForest University School of Medicine, Winston-Salem, North Carolina 27157,USA.s- Syndrome (SJS) is a rare but severe dermatological conditionthat typically occurs after the ingestion of medications such as nonsteroidaldrugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of thesyndrome can occur and may involve the conjunctiva, trachea, buccal mucosa,gastrointestinal tract, and genitourinary tract. Cholestatic liver disease,which may precede the skin manifestations of SJS, has been reported tooccur inSJS, but the medical literature has only 10 case reports describing thisphenomenon (1-9). We report the case of a 19-year-old female with SJS andcholestatic liver disease. A discussion of the underlying pathophysiologyof SJSand its treatment follows.Publication Types:Case ReportsReviewReview of Reported CasesPMID: 11713940 [PubMed - indexed for MEDLINE]3: Int J Dermatol. 1999 Nov;38(11):878-9.Pentoxyfylline in toxic epidermal necrolysis and s- syndrome.Sanclemente G, De la Roche CA, Escobar CE, Falabella R.Publication Types:Case ReportsLetterPMID: 10583942 [PubMed - indexed for MEDLINE]4: Int J Dermatol. 1998 Nov;37(11):833-8.Drugs causing fixed eruptions: a study of 450 cases.Mahboob A, Haroon TS.Department of Dermatology, King Medical College/Mayo Hospital, Lahore,Pakistan.BACKGROUND: Drug eruptions are among the most common cutaneous disordersencountered by the dermatologist. Some drug eruptions, although trivial, maycause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. Thediagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE:We evaluated 450 FDE patients to determine the causative drugs. RESULTS: Theratio of men to women was 1:1.1. The main presentation of FDE was circularhyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema,urticaria, dermatitis, periorbital or generalized hypermelanosis. OccasionallyFDE mimicked lichen planus, erythema multiforme, s- syndrome,paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichenplanusactinicus, discoid lupus erythematosus, erythema annulare centrifugum,pemphigusvulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis.Cotrimoxazole was the most common cause of FDE. Other drugs incriminated weretetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid,mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin,ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenacsodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin,allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was themost common cause of FDE, whereas FDE with diclofenac sodium, pyrantelpamoate,clindamycin, and albendazole were reported for the first time. FDE may havemultiform presentations.PMID: 9865869 [PubMed - indexed for MEDLINE]5: Gastroenterology. 1998 Sep;115(3):743-6.Drug-associated acute-onset vanishing bile duct and s-syndromes ina child.Srivastava M, -Atayde A, Jonas MM.Combined Program in Gastroenterology, Department of Medicine, Children'sHospital, Boston, Massachusetts, USA.Acute vanishing bile duct syndrome is a rare but established cause ofprogressive cholestasis in adults, is most often drug or toxin related, and isof unknown pathogenesis. It has not been reported previously in children.s- syndrome is a well-recognized immune complex-mediatedhypersensitivity reaction that affects all age groups, is drug or infectioninduced, and has classic systemic, mucosal, and dermatologic manifestations. Apreviously healthy child who developed acute, severe, rapidly progressivevanishing bile duct syndrome shortly after s- syndrome isdescribed; this was temporally associated with ibuprofen use. Despite therapywith ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestaticdisease was unrelenting, with cirrhosis shown by biopsy 6 months afterpresentation. This case documents acute drug-related vanishing bile ductsyndrome in the pediatric age group and suggests shared immune mechanismsin thepathogenesis of both s- syndrome and vanishing bile ductsyndrome.Publication Types:Case ReportsPMID: 9721172 [PubMed - indexed for MEDLINE]6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76.Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.Bigby M, Stern R.The nonsteroidal anti-inflammatory drugs are one of the most commonlyprescribedclasses of drugs used in medical practice. This review discusses the diversecutaneous reactions associated with nonsteroidal anti-inflammatory drugs.Adverse cutaneous reactions occur most frequently with benoxaprofen,piroxicam,sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The mostserious adverse cutaneous reactions, s- syndrome and toxicepidermal necrolysis, appear to be most often associated with sulindac andphenylbutazone. Tolmetin and zomepirac sodium, two structurally similarpyrrolederivatives, have been associated with a disproportionate number of cases ofanaphylactoid reactions. Among the currently marketed nonsteroidalanti-inflammatory drugs, piroxicam appears to have the highest rate ofphototoxic reactions. This phototoxic eruption is most often vesiculobullous.Publication Types:ReviewPMID: 3159761 [PubMed - indexed for MEDLINE]7: N Y State J Med. 1978 Jul;78(8):1239-43.s- syndrome plus toxic hepatitis due to ibuprofen.Sternlieb P, RM.Publication Types:Case ReportsPMID: 276660 [PubMed - indexed for MEDLINE]-------------------------------------------------------The material in this post is distributed without profit to those who haveexpressed a prior interest in receiving the includedinformation for research and educational purposes. For more information goto:http://www4.law.cornell.edu/uscode/17/107.htmlhttp://oregon.uoregon.edu/~csundt/documents.htmIf you wish to use copyrighted material from this email for purposes thatgo beyond 'fair use', you must obtain permissionfrom the copyright owner.--------------------------------------------------------Sheri Nakken, R.N., MA, Classical Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK$$ Donations to help in the work - accepted by Paypal accountvaccineinfotesco (DOT) net voicemail US 530-740-0561(go to http://www.paypal.com) or by mailVaccines - http://www.nccn.net/~wwithin/vaccine.htmVaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htmHomeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htmANY INFO OBTAINED HERE NOT TO BE CONSTRUED AS MEDICALOR LEGAL ADVICE. THE DECISION TO VACCINATE IS YOURS AND YOURS ALONE.******"Just look at us. Everything is backwards; everything is upside down.Doctors destroy health, lawyers destroy justice, universities destroyknowledge, governments destroy freedom, the major media destroy informationand religions destroy spirituality" .... Ellner Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2008 Report Share Posted March 30, 2008 This is far from the first lawsuit. A friend of mine was an aide to a girl who was permanently damaged from s-s disease and eventually died several years later. The parents sued, with their primary focus to have a warning on the medication. Obviously, they did not prevail, as there is still no warning label. > Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side > Effects > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 15, 2009 Report Share Posted August 15, 2009 >From: Binstock <binstock@...> The PubMed search ibuprofen AND stevens AND johnson generated 7 citations (1-7). Lynne Arnold wrote: Lawsuit Filed in Los Angeles Claims Children's Motrin Causes Severe Side Effects Is there any difference between Motrin and generic ibuprofen? Because the suit seems to be specifically about Motrin. Is that because this company originated ibuprofen? Lynne ibuprofen AND stevens AND johnson 1: J Pediatr. 2004 Aug;145(2):273-6. Acute vanishing bile duct syndrome after ibuprofen therapy in a child. Taghian M, Tran TA, Bresson-Hadni S, Menget A, Felix S, Jacquemin E. Pediatric Unit, Vesoul Hospital, Vesoul, France. We report the case of a 10 year-old girl who had s- syndrome and cholestasis after ibuprofen therapy. Liver histology was compatible with vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver tests normalized within 7 months. This report confirms that ibuprofen may induce acute vanishing bile duct syndrome. Publication Types: Case Reports Review Review of Reported Cases PMID: 15289784 [PubMed - indexed for MEDLINE] 2: Dig Dis Sci. 2001 Nov;46(11):2385-8. s- Syndrome and cholestatic hepatitis. Morelli MS, O'Brien FX. Department of Internal Medicine, Section of General Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. s- Syndrome (SJS) is a rare but severe dermatological condition that typically occurs after the ingestion of medications such as nonsteroidal drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, which may precede the skin manifestations of SJS, has been reported to occur in SJS, but the medical literature has only 10 case reports describing this phenomenon (1-9). We report the case of a 19-year-old female with SJS and cholestatic liver disease. A discussion of the underlying pathophysiology of SJS and its treatment follows. Publication Types: Case Reports Review Review of Reported Cases PMID: 11713940 [PubMed - indexed for MEDLINE] 3: Int J Dermatol. 1999 Nov;38(11):878-9. Pentoxyfylline in toxic epidermal necrolysis and s- syndrome. Sanclemente G, De la Roche CA, Escobar CE, Falabella R. Publication Types: Case Reports Letter PMID: 10583942 [PubMed - indexed for MEDLINE] 4: Int J Dermatol. 1998 Nov;37(11):833-8. Drugs causing fixed eruptions: a study of 450 cases. Mahboob A, Haroon TS. Department of Dermatology, King Medical College/Mayo Hospital, Lahore, Pakistan. BACKGROUND: Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist. Some drug eruptions, although trivial, may cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE: We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The ratio of men to women was 1:1.1. The main presentation of FDE was circular hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema, urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally FDE mimicked lichen planus, erythema multiforme, s- syndrome, paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen planus actinicus, discoid lupus erythematosus, erythema annulare centrifugum, pemphigus vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis. Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid, mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole were reported for the first time. FDE may have multiform presentations. PMID: 9865869 [PubMed - indexed for MEDLINE] 5: Gastroenterology. 1998 Sep;115(3):743-6. Drug-associated acute-onset vanishing bile duct and s- syndromes in a child. Srivastava M, -Atayde A, Jonas MM. Combined Program in Gastroenterology, Department of Medicine, Children's Hospital, Boston, Massachusetts, USA. Acute vanishing bile duct syndrome is a rare but established cause of progressive cholestasis in adults, is most often drug or toxin related, and is of unknown pathogenesis. It has not been reported previously in children. s- syndrome is a well-recognized immune complex-mediated hypersensitivity reaction that affects all age groups, is drug or infection induced, and has classic systemic, mucosal, and dermatologic manifestations. A previously healthy child who developed acute, severe, rapidly progressive vanishing bile duct syndrome shortly after s- syndrome is described; this was temporally associated with ibuprofen use. Despite therapy with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic disease was unrelenting, with cirrhosis shown by biopsy 6 months after presentation. This case documents acute drug-related vanishing bile duct syndrome in the pediatric age group and suggests shared immune mechanisms in the pathogenesis of both s- syndrome and vanishing bile duct syndrome. Publication Types: Case Reports PMID: 9721172 [PubMed - indexed for MEDLINE] 6: J Am Acad Dermatol. 1985 May;12(5 Pt 1):866-76. Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review. Bigby M, Stern R. The nonsteroidal anti-inflammatory drugs are one of the most commonly prescribed classes of drugs used in medical practice. This review discusses the diverse cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. Adverse cutaneous reactions occur most frequently with benoxaprofen, piroxicam, sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most serious adverse cutaneous reactions, s- syndrome and toxic epidermal necrolysis, appear to be most often associated with sulindac and phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar pyrrole derivatives, have been associated with a disproportionate number of cases of anaphylactoid reactions. Among the currently marketed nonsteroidal anti-inflammatory drugs, piroxicam appears to have the highest rate of phototoxic reactions. This phototoxic eruption is most often vesiculobullous. Publication Types: Review PMID: 3159761 [PubMed - indexed for MEDLINE] 7: N Y State J Med. 1978 Jul;78(8):1239-43. s- syndrome plus toxic hepatitis due to ibuprofen. Sternlieb P, RM. Publication Types: Case Reports PMID: 276660 [PubMed - indexed for MEDLINE] ------------------------------------------------------- The material in this post is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. For more information go to: http://www4.law.cornell.edu/uscode/17/107.html http://oregon.uoregon.edu/~csundt/documents.htm If you wish to use copyrighted material from this email for purposes that go beyond 'fair use', you must obtain permission from the copyright owner. Quote Link to comment Share on other sites More sharing options...
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