Re: Cortisol and DHEA Testing--NIL

[Guest guest]

Nil,

You wrote " DHEA So4 test gives good picture of DHEA status. " Is this a blood

test or a saliva test?

I have lot of cognitive trouble. Does the information mean that Cortisol is

best measured through saliva then?

Thanks again!

Sue

>

> Thanks to all who have answered my burning feet Inquiry.

>

> Cortisol is in two forms in the body.Free cortisol plus bound cortisol.Some

cortisol is bound by cortisol binding globulins and is not available for use.

> It has been observed that CBG levels of PWC's are higher than normal

population.

> " The SST relies on serum total cortisol responses. A

>

> large proportion of serum total cortisol is bound to

>

> CBG (80-90%). Thus, serum total cortisol levels are

>

> affected by variation in CBG. It has been shown that

>

> the changes in serum total cortisol levels do not correlate

>

> with cortisol production rates unless differences in

>

> CBG are corrected for (4). However, CBG is not routinely

>

> considered in the interpretation of total cortisol

>

> measurements. Our data suggest that CBG is important

>

> for the correct interpretation of dynamic tests of the

>

> HPA axis. "

>

> http://www.eje-online.org/content/146/2/231.full.pdf+html

>

> There was another article which stated that PWC's had higher CBG levels but I

could not find it at the moment.

> Serum cortisol test measures total cortisol level which is free plus

bounded.Therefore it does not give correct picture of available cortisol. Saliva

test gives directly free cortisol which is preferable but than there is problem

of finding and MD who will interpret and use it. You may need to see naturopath

for that.

>

> 24 hour urinary free cortisol test may also give better picture than serum

cortisol test.

>

> DHEA So4 test gives good picture of DHEA status.

> Best wishes

> nil