Guest guest Posted October 25, 2011 Report Share Posted October 25, 2011 Hi Sue, I have this on/off for many years. Many others I know also suffer with this following taking medications. The little I read about it discusses the vagus nerve not functioning properly and affects the muscle in the larynx. When I told doctors about it, they didn't know.... until I showed them some research from science journals! Its definitely not anxiety or stress related, having said that, physiological system is under stress from either illness, medications, toxicities, deficiencies... Copied and pasted from another forum: http://www.wisegeek.com/what-is-the-vagus-nerve.htm : Neuroscience. 2009 Sep 19. [Epub ahead of print] Links Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. Furuta S, Shimizu T, Narita M, Matsumoto K, Kuzumaki N, Horie S, Suzuki T, Narita M.Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. To verify whether vagal dysfunction is associated with chronic pain, we evaluated the effects of subdiaphragmatic vagotomy (vgx) on the sensitivity toward noxious stimuli in rats. Note that there's no tissue damage - no overt injury! One of the big problems for IBS and FM patients (and ME/CFS) is that there's no tissue damage but increased pain = which in the eyes of many means a psychological interpretation of their illness. This suggests it could be due to a damaged vagal nerve. Interestingly if I remember correctly Dr. Perrin believe poor vagal nerve functioning plays a key role in ME/CFS Vgx rats showed sustained hyperalgesia (increased pain) in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma CPK or LDH levels) accompanied by hypersensitivity to colonic distension. We found a dramatic increase in the levels of metabotropic glutamate receptor 5, protein kinase C (PKC) gammaand phosphorylated-PKCgamma within the spinal cord dorsal horn in vgx rats, which suggests that vgx may evoke sensory nerve plasticity. Interestingly Neurontin (gabapentin) which some ME/CFS patients find helpful did help to lower the pain level. Muscle hyperalgesia in vgx rats was also attenuated by gabapentin and amitriptyline, but was not affected by diclofenac, dexamethasone or diazepam. These findings indicate that subdiaphragmatic vagal dysfunction caused chronic muscle hyperalgesia accompanied by visceral pain and both gabapentin and amitriptyline were effective for subdiaphragmatic vagotomy-induced pain, which are partially similar to fibromyalgia syndrome. Furthermore, this chronic muscle pain may result from nociceptive neuroplasticity of the spinal cord dorsal horn. > > I keep having this feeling as if I'm being strangled or I have a lump in my throat. It gets worse later in the day. Has anyone else experienced this? I have an inhaler for asthma. I thought this might be an asthma symptom, but the inhaler doesn't help it at all. Does anyone know what this is or how to prevent/treat it? Is it possibly part of Fibromyalgia? > > Thank you for your help. > > Sue > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2011 Report Share Posted October 25, 2011 My earliest symptoms 19 years ago included difficulty in swallowing, but it largely went away. Then, after I went into respiratory failure a few years ago and almost died, something changed again, and since then I have this sensation of my throat tightening pretty regularly that matches what you describe (I don't have asthma though -- but I did once try and inhaler and, as with you, it did nothing). I think it is due to nerve damage but can't be sure, but it is a symptom of some neurological diseases. I'm not sure how to fix it. Peggy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2011 Report Share Posted October 27, 2011 Some " benign " causes of lump in the throat are reflux (GERD), and also a myofascial trigger point. The latter is especially true, if you happen to have TMJ problems. - Mark > > I keep having this feeling as if I'm being strangled or I have a lump in my throat. It gets worse later in the day. Has anyone else experienced this? I have an inhaler for asthma. I thought this might be an asthma symptom, but the inhaler doesn't help it at all. Does anyone know what this is or how to prevent/treat it? Is it possibly part of Fibromyalgia? > > Thank you for your help. > > Sue > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2011 Report Share Posted October 28, 2011 Have you by any chance had a whip lash event? OR slept in bad position??? I was rear ended in car long time ago----------went through exhaustive testing due to same symptom you describe. OLD chiropractor treated me, and it was gone in a few simple treatments. God Bless, Sara > > > > I keep having this feeling as if I'm being strangled or I have a lump in my throat. It gets worse later in the day. Has anyone else experienced this? I have an inhaler for asthma. I thought this might be an asthma symptom, but the inhaler doesn't help it at all. Does anyone know what this is or how to prevent/treat it? Is it possibly part of Fibromyalgia? > > > > Thank you for your help. > > > > Sue > > > Quote Link to comment Share on other sites More sharing options...
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