micro mileau in tissue,cancer/ blood volume/blood pressure/cardiovascular

[Guest guest]

Please comment if you can summarize this and how it could help cfids patients.

Amy

http://www.uib.no/biomedisin/en/nyheter/2011/04/new-diagnostic-possibilities

University of Norway

27.04.2011 News

New diagnostic possibilities

Recent knowledge regarding fluid constituting the body's microenvironment gives

new diagnostic possibilities.

By Terje Erstad

Helge Wiig

Professor Helge Wiig Foto: Jan Reidar Lothe

Cardiovascular research has provided valuable knowledge on the micro-milieu in

tissue, this leading to the possibility of understanding complicated mechanisms

in the body, and diagnosing cancer.

Professor Helge Wiig at the Department of Biomedicine, is a physiologist, and is

the leader of the department's research group in heart and circulation research.

During his whole career, Wiig has had focus on the microenvironment in tissue

with special interest on fluid that is an important component in this respect.

In recent years the group that he leads has directed particular interest to the

interstitial fluid that " bathes " both cells and structural elements in

connective tissue. In many organs this fluid is not directly available, such

that they are working on methods to establish procedures for its isolation.

Cancer tissue is an example where this is important, and the group showed a

number of years ago that they could isolate interstitial fluid from a tumour by

exposing the tissue to increased G-force (see article in American Journal of

Physiology).

This work gave rise to a series of experiments where factors of importance for

fluid exchange and local release of signal molecules in other organs were

studied, especially where the availability of this fluid is difficult, for

example in human bone marrow (see article in Clinical Cancer Research).

Wiig and co-workers have now " translated " the method for use with solid human

tumours and have demonstrated that they can gain access to fluid that is

representative of interstitial fluid in ovarian cancer, and are working on this

to study secretion of tumour specific proteins that can be used for example as

diagnostic markers.

Another area of interest of the group is the effect of structural elements in

connective tissue on the expression of extracellular proteins in interstitial

fluid. Wiig and his colleagues have worked on methods to quantitate this effect

by separating the pure steric effect from the charged effect and relating this

to hydration (see article in the Journal of Physiology).

This phenomenon is of consequence for the regulation of the fluid volume in the

body, and has received recent attention after it has been shown that connective

tissue in the skin is important in the regulation of both blood volume and

pressure.

For a number of years the group has also been interested in the role of lymph

capillaries in the regulation of fluid volume, and through international

collaboration has gained access to genetically manipulated mice such that these

effects can be quantified (see article in Journal of Physiology).

The group has also used lymph in order to study the local production of signal

molecules in the spleen and in addition have demonstrated that cells that pass

through the interstitia in the spleen become in some way " affected " as a result

of this passage (see article in Journal of Immunology).

Link to Helge Wiig's research group.

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Last updated 28.4.2011

Nyheter fra The Department of Biomedicine

* Annual symposium (07.06.2011)

* The 4th annual NorMIC meeting 2011 (07.06.2011)

* Availability of oxygen modulates tumour growth (30.05.2011)

* PhD Jill Anette Opsahl (22.05.2011)

* New diagnostic possibilities (27.04.2011)

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