Re: EBV and cancer

[Guest guest]

I have often heard that having had EBV gives you a higher risk for breast

cancer. But I can't remember the studies and how high the risk is. I did have

raging EBV for a few years but I guess I don't worry that much about it because

nobody in my family ever gets cancer. (We have every other health problem known

to man, but not cancer!)

Doris

[Guest guest]

95% of the population would test positive for EBV exposure. in india, 99% of

babies have already been exposed, and they have very little breast cancer over

there. maybe the problem is EBV's interaction with other viruses..like in our

disease? or maybe you have to have the full blown mono as a teen or adult to

elevate ur cancer risk...as in MS.? when babies get EBV, they hardly ever get

mono...

From: Doris Brown <dorisbrown9@...>

Subject: Re: EBV and cancer

Received: Saturday, June 11, 2011, 12:36 AM

 

I have often heard that having had EBV gives you a higher risk for breast

cancer. But I can't remember the studies and how high the risk is. I did have

raging EBV for a few years but I guess I don't worry that much about it because

nobody in my family ever gets cancer. (We have every other health problem known

to man, but not cancer!)

Doris

[Guest guest]

Hi There

I can't speak to the EBV/cancer link but I have heard (from the top

AIDS/Cancer/CFIDS doctor in Houston Texas in the 90's) that people with CFIDS

have a higher incidence of cancer because of the imbalance of the TH1/TH2 immune

function and the low NK cell function.

from wiki:

Th1 and Th2: helper T cell responses

" Two types of effector CD4+ T helper cell responses can be induced by a

professional APC, designated Th1 and Th2, each designed to eliminate different

types of pathogens. The factors that dictate whether an infection will trigger a

Th1 or Th2 type response are not fully understood, but the response generated

does play an important role in the clearance of different pathogens.[1]

http://en.wikipedia.org/wiki/Adaptive_immune_system

" The Th1 response is characterized by the production of Interferon-gamma, which

activates the bactericidal activities of macrophages, and induces B-cells to

make opsonizing (coating) antibodies, and leads to " cell-mediated immunity " .[1]

The Th2 response is characterized by the release of Interleukin 4, which results

in the activation of B-cells to make neutralizing (killing) antibodies, leading

to " humoral immunity " .[1] Generally, Th1 responses are more effective against

intracellular pathogens (viruses and bacteria that are inside host cells), while

Th2 responses are more effective against extracellular bacteria, parasites and

toxins.[1] "

_____________________________

from a talk given by Dr. Cheney - this is not copyrighted material but good

information from Dallas Fort Worth CFIDS Support Group website. I would imagine

that the basic information is still valid but the treatment(s) would be outdated

based on his most recent research. Not sure so research this or sign up for his

service to get more recent treatment options.

http://www.anapsid.org/cnd/diagnosis/cheneyis.html

best to read the whole thing but here are two small excerpts:

" Dr. Cheney explained that the immune system has two different modes of attack,

based on the type of invader. One is Th1 (T Helper 1). It goes after organisms

that get inside our cells ‚ intracellular pathogens. It is also known as

cell-mediated immunity. The other is Th2 (T Helper 2). It attacks extracellular

pathogens ‚ organisms that are found outside the cells in blood and other body

fluids. Some call this humoral or antibody-mediated immunity. A healthy immune

system is dynamic, able to switch back and forth as needed, quickly eradicating

one threat and then resting before responding to the next. "

(Dr. Cheney began this conversation by drawing a large inverted " V " . At the top

point he wrote " Th0 " , which he called " Th naught " . The left arrow pointed down

to " Th1 " and the right arrow to " Th2 " . The arrow on the right was much darker

and thicker, indicating that CFIDS patients are Th2 activated.)

Th0 are the naive, or unformed, cells of the immune system. They are resting,

just waiting for an invader. When infection occurs, they convert to either Th1

or Th2, depending on the type of threat. When the resting cell is exposed to a

virus, cancer, yeast, or intracellular bacteria (like mycoplasma or chlamydia

pneumonia), the Th1 response is initiated. (Dr. Cheney wrote these organisms

beside the left arrow.) The weapons of the Th1 system include cytotoxic T cells

and Natural Killer (NK) cells. (Cheney drew these below " Th1 " .)

On the other side are normal bacteria, parasites, toxins, and allergens.

(Likewise written beside the right arrow.) These trigger a predominately Th2

response. Its weapons include eosinophiles (Eos), polymononuclear cells (PMN),

and antibody secreting cells (Ab). (Likewise written below " Th2 " .)

How does the naive cell know which pathway to take? It depends on the cytokine

information received. The presence of any organism from the left side triggers

production of a cytokine called Interleukin 12. IL-12 causes the Th0 cell to

move down the Th1 path. On the other hand, organisms on the right side trigger

the production of Interleukin 10 (IL-10), which causes the Th0 cell to move down

the Th2 path. (Cheney added small vertical dotted lines on each side, pointing

upward to " IL-12 " on the left and " IL-10 " on the right. He then drew horizontal

dotted arrows from " IL-12 " and " IL-10 " , each pointing inward toward the " Th0 " ,

indicating that these cytokines determine whether it will become Th1 or Th2.)

..

..

..

..

Cheney said this is the point where it gets very interesting. Viruses,

especially herpes viruses like EBV, CMV and HHV6, make proteins that mimic

IL-10. The virus deceives the immune system into thinking that the threat is

coming from the opposite side! So the immune system shifts from the Th1 mode

that attacks viruses to the Th2 mode that does not. The virus increases its

chances of survival by diverting the immune system. It is now thought that many,

if not most, pathogens have this ability. (To represent this effect, Cheney drew

a horizontal arrow about half way down the inverted " V " , originating from the

left side and pointing toward, but not quite touching, the right side. The line

was labeled " IL-10 like peptides " . Below it he drew a similar arrow from the

right side that almost reached the left side. It was labeled " IL-12 like

peptides " .)

HTH

Marti

>

> Can anyone comment on this theory that EVB IS a cancer virus?

> And what can we do as precautionary treatments/supplements etc?

>

> http://en.wikipedia.org/wiki/Harald_zur_Hausen

>

[Guest guest]

" amy " <amydent9@...> wrote:

>

> Can anyone comment on this theory that EVB IS a cancer virus?

> And what can we do as precautionary treatments/supplements etc?

>

> http://en.wikipedia.org/wiki/Harald_zur_Hausen

>

I'm no expert on this, but my understanding is that EBV is associated with

cancer in Africa, but not in North America. I don't know why that is, but would

guess that there is some other pathogen, possibly another virus, that is needed

*in addition to* EBV in order to produce the cancer, and that this additional

pathogen is common in Africa but not in North America. (Another possibility is

that malnutrition in Africa reduces immunity, leading to forms of EBV infection

in Africa that are rare in the US.)

There are other clear examples where two viruses are needed to produce cancer.

For example, most cases of Kaposi's Sarcoma (a serious cancer that forms mostly

on the skin) are caused by the combination of Herpes 8 plus HIV.

-- Judith Shapiro