integrates kindling & oxidative stress

[Guest guest]

Has anyone read this?

Journal of Behavioral and

Neuroscience Research 2009, Vo1. 7, 1-17

REVIEW

Kindling and Oxidative

Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

 

 

L. A. 1*, N.

Porter1, J. Herrington1, M. Sorenson1 & S. Kubow2

1 De University and 2 McGill

University Myalgic

 

Myalgic Encephalomyelitis/

Chronic Fatigue Syndrome (ME/CFS) is one of the more complex illnesses

involving multiple systems within the body. Onset of ME/CFS frequently occurs

quickly and many patients report a prior exposure to a viral infection. This

debilitating illness can affect the immune, neuro-endocrine, autonomic and

neurologic systems. Abnormal biological findings among some patients have

included aberrant ion-transport and ion-channel activity, cortisol-deficiency,

sympathetic nervous system hyperactivity, EEG spike waves, left ventricular

dysfunction in the heart, low natural killer cell cytotoxicity and a shift from

Th1 to Th2 cytokines. We propose that the

kindling and oxidative stress theories provide a heuristic template for better

understanding the at times conflicting findings regarding the etiology and

pathophysiology of this illness.