Thermoregulation

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Hi All

Anyone have profound thermoregulation problems?

In the face of normal thyroid profile and very blunted response to additional

T4, T3 or combination of the two, I have problems maintaining a temperature of

36.2C. If I wake at that level, my temp frequently drops to 35.9 regardless of

what I do (except lie in a very hot bath)

If I go for a walk, it is not uncommon for my temp to drop from 36.2 to below

35, the lowest has been 34.4 despite wearing more warm clothes than one can

comfortably move in.

If I sit bolt-upright, without moving, my temp will sometimes come up to 36.5.

Even at my coldest I don't shiver but paradoxically, I sometimes start to sweat

at 36.3 and sweat heavily if I can manage to get to 36.9 or higher. My only

consistent way of raising temp to near normal is to lie down in bed with a hot

water bottle.

At 36.9 or above, my brain fog is replaced with discomfort and nausea, a real

catch 22 situation.

The literature on hypothermia is pretty sparse, I doubt that I have Shapiro's

Syndrome with agenesis of the corpus callosum (brain scans show up pretty

normal)

see http://toledopaincenter.com/pdf/890922.pdf

However I wonder about norepinephrine dysregulation as a factor and if Clonidine

may offer possible treatment.

Recent work on MS by o Zamboni has identified Chronic CerebroSpinal Venous

Insufficiency CCSVI as a factor in the maintenance (and possibly the aetiology)

of MS. One aspect that might affect thermoregulation is that where the primary

veins leaving the brain (jugulars) are blocked or stenosed, there can be

vascular reflux which alters, among other things, the thermal balance of the

brain. As the primary thermostatic control centre is in the hypothalamus, if

there is heat build-up in the brain, there is a distinct and plausible

possibility that the hypothalamic thermostat might be reset to prevent the brain

overheating.

One of the consistent comments by those who have undergone Zamboni's " Liberation

Procedure " of balloon venoplasty to dilate the stenosed jugulars is a return to

normal patterns of temperature regulation and tolerance (notoriously disrupted

in MS)

see http://www.thisisms.com/ftopict-11354-.html

and the embedded links

http://jap.physiology.org/cgi/content/full/105/2/400

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442822/

See also http://csvi-ms.net/en/content/ccsvi-huge-breakthrough-ms

Love some feedback

R