Re: Atrial symptoms

[Guest guest]

I found the message that I was looking for. It was in the 'Anybody else

prefers to be up at night' thread. And it was arterial dialation. I think

this XMRV receptor in the arterial walls stuff could be important but I

guess it's another one of those things that we'll just have to wait and see

how the science works out.

Beverly

> Several days ago I read something in a thread here that made reference to

> atrial blood pressure or arterial blood pressure. I didnt reply right away

> because of brain fog and now I cant find the original thread so I started

> a

> new one. Anyway, I wanted to point out this info which comes from the blog

> Hope for FM and CFIDS Sufferers. SYG1 is one of the receptors that XMRV

> binds to.

>

> http://cfidsresearch.blogspot.com/2009/11/modus-operandi-part-ii.html

>

> " My theory centers around the SYG1 membrane protein, which has been

> identified as a synaptic guidepost, directing neurons to connect to each

> other. The SYG1 protein is in the immunoglobulin superfamily, with an

> extracellular domain, a single transmembrane segment, and an intracellular

> loop. SYG1 binds to its receptor SYG2, which is also a member of the

> immunoglobulin superfamily. Ironically, SYG1 is most heavily expressed

> during fetal development and early childhood, and its expression greatly

> diminishes thereafter. In adulthood, it continues to be expressed in the

> limic region (which includes the hypothalamus), at neuromuscular junctions

> in skeletal muscle, and in arterial walls. When it is activated, it

> initiates selective synapse elination through the SCF-Ubiquitin ligase

> complex - when it works properly, SYG1 binds to SKR, inhibiting formation

> of

> the SCF complex (Skp1-cullin-F-Box complex), protecting nearby synapses. "

>

> I thought it was interesting that SYG1 is expressed in arterial walls and

> didnt know how that related to CFIDS symptoms. The thread that was talking

> about blood pressure symptoms seemed like it may illuminate the

> connections,

> but right now I am still too brain fogged to try to make sense of it.

> (Winter is the cedar pollen season in TX.)

>

> Beverly

>

>

>

>

>

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>

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