XMRV, NF-KB, and cortisol (Re: The spin by other doctors continue).

[Guest guest]

Hi - Adrenal insufficiency has not been shown in CFS:

http://psy.psychiatryonline.org/cgi/content/full/44/2/113

However, suppressed cortisol production (due to a higher negative feedback

response) has been shown in CFS

http://www.psychosomaticmedicine.org/cgi/content/full/64/2/311#R11-094385

Low morning cortisol salivary has been found in women with CFS in one study.

Another study infers that this could be due to childhood abuse:

http://www.ncbi.nlm.nih.gov/pubmed/19124690

Low cortisol is just as likely to be the cause of infections, as high cortisol

is:

http://ajp.psychiatryonline.org/cgi/content/abstract/160/9/1554

" Previous theories have emphasized the role of excessive glucocorticoid activity

in the pathology of chronic stress. Nevertheless, insufficient glucocorticoid

signaling (resulting from decreased hormone bioavailability or reduced hormone

sensitivity) may have equally devastating effects on bodily function. Such

effects may be related in part to the role of glucocorticoids in restraining

activation of the immune system and other components of the stress response,

including the sympathetic nervous system (SNS) and corticotropin-releasing

hormone (CRH). "

- Mark