XMRV Receptors

[Guest guest]

I've never taken cortisol, but I have taken progesterone and that is the one

that's an issue for me. This receptor on XMRV apparently binds progesterone too.

Nicola

[Moderator: XMRV Receptors:

Note that XMRV infections could be: " reflective of the reduced antiviral status

of RNase L QQ individuals " , thus not causal, but a consequence...

" XMRV is using the cellular receptor for xenotropic and polytropic MLVs (XPR1)

....

XMRV is sensitive to Interferon (IFN), which would be consistent with the fact

that it is found in PCs from patients with the RNase L QQ but not the RR

genotype "

" Viral integration sites were localized to the genes for two transcription

factors (CREB and NFAT) and a suppressor of androgen receptor transactivation

(APPB2/PAT1/ARA67); the potential involvement of these genes in PC is at least

plausible. The fact that XMRV is IFN-sensitive and detected at high frequency in

PCs from Hpc1 QQ families supports a possible role for XMRV in PC. However,

another possibility is that XMRV is not causal to PC but reflective of the

reduced antiviral status of RNase L QQ individuals; another novel virus whose

sequences were not detected by the ViroChip might be the relevant agent "

http://www.pnas.org/content/104/5/1449.full "

Note: " CREB proteins in neurons are thought to be involved in the formation of

long-term memories " ]