XMRV, NF-KB, and cortisol (Re: The spin by other doctors continue).

[Guest guest]

Hi Mark,

I think we are missing the point that the cortisol levels fluctuate from the

beginning of the illness through the duration.

I think that it would be safe to say that for a majority of the population -

high cortisol levels are common at the beginning of the illness as the body

fights the trigger, whatever that may be.

As the adrenals wear out trying to continue to produce these high levels for an

extended period of time, then a time of low cortisol has begun and most of us

remain there - some form of adrenal fatigue.

In later stages of illness, the adrenals mount one last effort and produce high

levels of cortisol until they finally wear out permanently, no longer adrenal

fatigue but adrenal insufficiency or perhaps even s.

Anyway, those are my thoughts and understanding of the adrenal cycle in

ME/CFIDS. I certainly could be wrong.

In addition, I think that study was flawed in using CBT as a defining factor as

it seems too subjective. Also, were all study participants in the same phase of

illness and in the same stage of adrenal fatigue. What was the genetic makeup?

A lot of factors playing a part.

This is what Dr. M. stated in Reno Interview. Have there been other interviews

or statements to expound on this?

" discovered in prostrate cancer in men in 2006 by Silverman.

Simple retrovirus, on or off.

Three things control in unpublished data

response to hormones

response to inflammatory cytokines

NF b element (?)

Cortisol, the stress hormone, turns on virus very rapidly and continues to keep

it expressed so inflammatory events as caused by other pathogens.

and so do androgens and progesterones which makes sense in prostate cancer and

in the disease in women. "

Marti

>

> Hi - Thanks for the info, but according to that same article, it's the

presence of that receptor which is believed to be the reason that lab studies

show that male mice are significantly more susceptible to retrovirus infection

than female mice. They attribute this due to the presence of testosterone.

However, according to CFS studies, significantly more women get CFS than men.

>

> Additionally, see the following study:

>

> http://www.ncbi.nlm.nih.gov/pubmed/19607750

>

> " CONCLUSIONS: Low cortisol is of clinical relevance in CFS, as it is

associated with a poorer response to CBT. Hypocortisolism could be one of

several maintaining factors that interact in the persistence of CFS. "

>

> If the interaction between cortisol and XMRV was significant in CFS, then the

above study conflicts with that. Higher cortisol levels should have been

associated with poorer treatment response, if that interaction was significant.

- Mark