antifolate success in CFS trials link to methylation issues

[Guest guest]

Hi,

Can anyone shed light on the link between supposed succes

with the use of antifolate methotexrate treatment in CFS.

http://www.biomedcentral.com/1471-2377/9/28/abstract

and methylation issues in CFS ? These findings seem to contradict hypothesis of

little available folate or tetrahydrofolate in CFS?

Per