Garlic: Pubmed

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Polysulfides as biologically active ingredients of garlic.

" The chemistry underlying the biological activity of these

polysulfides is currently emerging. It seems to include a combination

of several distinct transformations, such as oxidation reactions,

superoxide radical and peroxide generation, decomposition with

release of highly electrophilic S(x) species, inhibition of

metalloenzymes, disturbance of metal homeostasis and membrane

integrity and interference with different cellular signalling

pathways. Further research in this area is required to provide a

better understanding of polysulfide reactions within a biochemical

context. This knowledge may ultimately form the basis for the

development of 'green' antibiotics, fungicides and possibly

anticancer agents with dramatically reduced side effects in humans.

PMID: 17571177

" The gram-negative diarrheagenic pathogens from the stool samples

were highly sensitive to garlic, while ciprofloxacin (CPX) was most

effective against E. coli. The differences were inferred to result

from genetic differences among the organisms and differences in the

modes of action of the antibiotics. No isolates were resistant to

garlic, making it a promising antimicrobial agent. It appears that

antibiotics that interfere with DNA and RNA syntheses, such as garlic

does, could constitute an effective partner in the synergic effect of

garlic currently being investigated worldwide. "

PMID: 17539285

" Garlic (Allium sativum) has come to be seen as an all rounded

treatment for preventing wound infection, common cold, malaria, cough

and lung tuberculosis, hypertension, sexually transmitted diseases,

mental illness, kidney diseases, liver diseases, asthma, diabetes. "

PMID: 17370439