Guest guest Posted October 4, 2006 Report Share Posted October 4, 2006 According to Diggle et al (BMJ, 16 Sept 2006, 571-4), use of long needles could significantly reduce vaccine reactogenicity. In their study, the percentage of infants experiencing local reactions after intramuscular injection went up to 61% for a combined vaccine and 42% for a meningococcal vaccine; 2% of the included subjects were withdrawn due to severe local or general reactions. Fairly recently, however, in a plea for " the importance of injecting vaccines into muscle " , Zuckerman5 contended that after intramuscular injection, only. 0.4% of the patients had local adverse effect. Even taking into account potential disparities in the criteria used for reporting or coding, it is extremely difficult to reconcile such conflicting results. And every attempt to do so notwithstanding, an even more crucial question concerns the clinical or epidemiological relevance of estimates which can display such phenomenal fluctuations. For not speaking about prescribers information, and even less: about the " informed " consent of parents who gather information from doctors who received such informative data! Although it was recently pointed out4 5, most of health professionals remain unaware of this worrying lack of reliability of safety data about medicines (from the clinical trials as well as from post-marketing surveillance). Some may think that the above comparison between two estimations of local reactions is a caricature, but this is not the case: while monitoring of iatrogenic hazards is certainly poorer with vaccines than with other drugs1-3 5, examples of irresponsible management of drug safety by manufacturers as well as governmental agencies could easily be extended to a number of non-vaccine products. References 1. Anon. WHO urges better monitoring of vaccine ADRs. Scrip 2006; 13. 2. Bonhoeffer J, Zumbrunn B, Heininger U. Reporting of vaccine safety data in publications: systematic review. Pharmacoepidemiol Drug Saf 2005; 14:101-6. 3. Girard M. Vaccination and auto-immunity: reassessing evidence. Medical Veritas 2005; 2:549-54. 4. Ioannidis JP, Lau J. Completeness of safety reporting in randomized trials: an evaluation of 7 medical areas. JAMA 2001; 285:437-43. 5. Zuckerman JN. The importance of injecting vaccines into muscle. Different patients need different needle sizes. BMJ 2000; 321:1237-8. See: http://bmj.bmjjournals.com/cgi/eletters/333/7568/571#143221 Kindest regards to all of you. M -------------------------------------------------------- Sheri Nakken, R.N., MA, Hahnemannian Homeopath Vaccination Information & Choice Network, Nevada City CA & Wales UK $$ Donations to help in the work - accepted by Paypal account earthmysteriestours@... voicemail US 530-740-0561 (go to http://www.paypal.com) or by mail Vaccines - http://www.nccn.net/~wwithin/vaccine.htm Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm Reality of the Diseases & Treatment - http://www.nccn.net/~wwithin/vaccineclass.htm Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm Quote Link to comment Share on other sites More sharing options...
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