Guest guest Posted May 3, 2006 Report Share Posted May 3, 2006 Does anyone know if high c-reactive protein levels can be/are associated with viral problems? - high herpes 6 titers. The CRP has been high x 2 measurements when our daughter seems 'sick'-no fever, elevated wbc or sed rate etc; just a mom's 'thought'. It falls on its own eventually. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 3, 2006 Report Share Posted May 3, 2006 Does anyone know if high c-reactive protein levels can be/are associated with viral problems? - high herpes 6 titers. The CRP has been high x 2 measurements when our daughter seems 'sick'-no fever, elevated wbc or sed rate etc; just a mom's 'thought'. It falls on its own eventually. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2007 Report Share Posted July 2, 2007 High CRP is not specific. It indicates inflammation somewhere in the body. But given that mine was low normal for several years now and then this past year with the headache and nerve damage it has gotten higher and higher I would suspect that I have inflammation, probably in my brain, possibly arteries of the brain. Trouble is, all my symptoms are at a low enough level that no one can diagnose an actual infection. This may be because I was on Zithromax and then diflucan and peniccillin which controlled things but didn't cure???? I am just guessing. a > > What could high CRP mean for us.Mine is also high. > bw > Nil > Re: a > > > > Oh yes, I have been seriously considering this. But then got > > sidetracked. Partly this is because I had an elevated EBV titre and a > > very high c reactive protein result when the head pressure began, so I > > wanted to see what the Valtrex would do. (also tried diflucan and > > pennicillin with no effect) Now the chiropractor is beginning to look > > like a possibility. I am thinking along the lines of mechanical > > disruption of spinal fluid flow and inflammation. It's hard to say how > > much cfs or Lyme is underlying my current trouble. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2007 Report Share Posted July 2, 2007 Thank you for your answer.Could it be that you have an overall inflammation but damage is more in the brain?As you might remember I also have the same problem and gives me very hard time lately. For the last three days I also started to get very slight strange smell and taste. I think some seizure type activity is developing. I am afraid this inflammation is damaging my brain.I think vit D helps.Have you taken saliva cortisol test?Could you below in cortisol? I am telling you this but I am on 20 mg HC eq. of isocort. This is the top dosage. Don't know what else I can do?strange thing is that mine is on the left side only? bw nil Re: high crp > High CRP is not specific. It indicates inflammation somewhere in the > body. But given that mine was low normal for several years now and > then this past year with the headache and nerve damage it has gotten > higher and higher I would suspect that I have inflammation, probably > in my brain, possibly arteries of the brain. Trouble is, all my > symptoms are at a low enough level that no one can diagnose an actual > infection. This may be because I was on Zithromax and then diflucan > and peniccillin which controlled things but didn't cure???? I am just > guessing. > > a >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2007 Report Share Posted July 2, 2007 Nil, these symptoms of yours concern me. I hope that you've called your doctor recently and talked with him (or her) about them. I'd be inclined to ask for a brain scan of some sort to rule out other causes. Just because our chronic fatigue etc problems are uppermost in our minds, it doesn't mean other things can't crop up. Do be careful with yourself. Marcia on in Salem, Massachusetts > > Thank you for your answer.Could it be that you have an overall inflammation > but damage is more in the brain?As you might remember I also have the same > problem and gives me very hard time lately. For the last three days I also > started to get very slight strange smell and taste. I think some seizure > type activity is developing. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2007 Report Share Posted July 4, 2007 Starting with the CRP first to see if you're elevated is the best way to go, and if you are, then I would test on as many pro-inflammatory cytokines as much as possible to try and find the cause of the infllammation: TNF-alpha, Il-6, 8, 12, etc. These can be done through 3 sources I located: Life Extension Foundation has their own panel for covenience, although it isn't covered by insurance, and is actually done at LabCorp. _http://www.lef.org/newshop/items/itemLCCYT.html_ (http://www.lef.org/newshop/items/itemLCCYT.html) LabCorp - you have to order them separately Specialty Labs - order separately Cytokines do, in fact, pinpoint what may be the root causes of inflammation _http://en.wikipedia.org/wiki/Interleukin_ (http://en.wikipedia.org/wiki/Interleukin) _http://www.lef.org/protocols/prtcl-146.shtml_ (http://www.lef.org/protocols/prtcl-146.shtml) In a message dated 07/02/07 5:22:03 PM Pacific Daylight Time, yildiz22@... writes: Thank you for your answer.Could it be that you have an overall inflammation but damage is more in the brain?As you might remember I also have the same problem and gives me very hard time lately. For the last three days I also started to get very slight strange smell and taste. I think some seizure type activity is developing. I am afraid this inflammation is damaging my brain.I think vit D helps.Have you taken saliva cortisol test?Could you below in cortisol? I am telling you this but I am on 20 mg HC eq. of isocort. This is the top dosage. Don't know what else I can do?strange thing is that mine is on the left side only? bw nil ************************************** See what's free at http://www.aol.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 5, 2007 Report Share Posted July 5, 2007 Would you please explain how finding which cytokines are elevated would reveal the cause of the inflammation? Thanks, a Carnes > > > Starting with the CRP first to see if you're elevated is the best way to go, > and if you are, then I would test on as many pro-inflammatory cytokines as > much as possible to try and find the cause of the infllammation: TNF-alpha, > Il-6, 8, 12, etc. These can be done through 3 sources I located: > > Life Extension Foundation has their own panel for covenience, although it > isn't covered by insurance, and is actually done at LabCorp. > _http://www.lef.org/newshop/items/itemLCCYT.html_ > (http://www.lef.org/newshop/items/itemLCCYT.html) > > LabCorp - you have to order them separately > > Specialty Labs - order separately > > Cytokines do, in fact, pinpoint what may be the root causes of inflammation > _http://en.wikipedia.org/wiki/Interleukin_ > (http://en.wikipedia.org/wiki/Interleukin) > _http://www.lef.org/protocols/prtcl-146.shtml_ > (http://www.lef.org/protocols/prtcl-146.shtml) > > In a message dated 07/02/07 5:22:03 PM Pacific Daylight Time, > yildiz22@... writes: > > > > > Thank you for your answer.Could it be that you have an overall inflammation > but damage is more in the brain?As you might remember I also have the same > problem and gives me very hard time lately. For the last three days I also > started to get very slight strange smell and taste. I think some seizure > type activity is developing. I am afraid this inflammation is damaging my > brain.I think vit D helps.Have you taken saliva cortisol test?Could you > below in cortisol? I am telling you this but I am on 20 mg HC eq. of > isocort. This is the top dosage. Don't know what else I can do? strange thing > is that mine is on the left side only? > bw > nil > > > > > > > > > > ************************************** See what's free at http://www.aol.com. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 6, 2007 Report Share Posted July 6, 2007 While more specific than a generalized marker of inflammation as with the CRP test, it appears as shown in bold below that elevated cytokine levels can pinpoint at least a group of certain causes of inflammation: Interleukin-1 beta (IL-1b) This test is used to identify elevated levels of Interleukin-1 beta. IL-1b is a cytokine produced principally by mononuclear phagocytes but also by various other cells types including keratinocytes, epithelium and cells of the CNS. Elevated levels of Interleukin-1 beta have been implicated in sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, inflammatory bowel disease, anorexia, AIDS, and graft-versus-host disease associated with bone marrow transplants. IL-1B is one of the key mediators of immunobiological responses to physical stress, a pilot study showed that higher levels were associated with anxiety/panic disorder. Higher than normal levels have also been associated with a significant increased risk of myocardial infarction independent of Cardio-CRP levels. Interleukin-6 (IL-6) This test is used to identify elevated levels of Interleukin-6. IL-6 is a cytokine produced by many different cells including monocytes/macrophages, fibroblasts, endothelial cells, keratinocytes, mast cells, T cells and many tumor cell lines. Elevated IL-6 serum or plasma levels may occur in different conditions including sepsis, autoimmune diseases, lymphomas, AIDS, alcoholic liver disease, tumor development, Alzheimer’s disease, and in c with infections or transplant rejection. Elevated levels of IL-6 may be associated with an increased risk of heart attack, and stroke. Interleukin-8 (IL-8) This test is used to identify elevated levels of Interleukin-8. IL-8 is produced by stimulated monocytes, macrophages, fibroblasts, endothelial cells, keratinocytes, melanocytes, hepatocytes, chondrocytes, and a number of tumor cell lines. In many types of cells the synthesis of IL8 is strongly stimulated by IL1 and TNF-alpha. Elevated concentrations are observed in psoriasis rheumatoid arthritis, chronic polyarthritis, tumor development and Hepatitis C. Tumor necrosis factor alpha (TNF-a) This test is used to identify elevated levels of Tumor necrosis factor alpha. A variety of cells are shown to produce TNF- .TNF- is a growth factor for fibroblasts and stimulates the synthesis of collagenase and prostaglandin E2. Bone resorption can be induced by TNF- because it activates osteoclasts. TNF- enhances the proliferation of T cells after stimulation with IL-2. In the absence of IL-2, TNF- induces the proliferation and differentiation of beta cells. TNF- levels may be elevated in sepsis, cachexia, AIDS, Hepatitis C, transplant rejection, various infectious and autoimmune diseases. Just having an infection like Lyme, HHV6, EBV, CMV, etc. alone can elevate cytokines which, in turn, elevate your CRP and make one higher risk for other degenerative diseases. At the very least, you would know which cytokines are elevated that are the more (or less) potentially life-threatening down the pike. It's also another way to challenge the accuracy of the CRP test. I just figure that the more data one is equipped with, the closer to final resolution. In a message dated 07/05/07 1:17:35 PM Pacific Daylight Time, pj7@... writes: Would you please explain how finding which cytokines are elevated would reveal the cause of the inflammation? Thanks, a Carnes > > > Starting with the CRP first to see if you're elevated is the best way to go, > and if you are, then I would test on as many pro-inflammatory cytokines as > much as possible to try and find the cause of the infllammation: TNF-alpha, > Il-6, 8, 12, etc. These can be done through 3 sources I located: > > Life Extension Foundation has their own panel for covenience, although it > isn't covered by insurance, and is actually done at LabCorp. > __http://www.lef.http://www.lhttp://www.lef.http:_ (http://www.lef.org/newshop/items/itemLCCYT.html_) > (_http://www.lef.http://www.lhttp://www.lef.http_ (http://www.lef.org/newshop/items/itemLCCYT.html) ) > > LabCorp - you have to order them separately > > Specialty Labs - order separately > > Cytokines do, in fact, pinpoint what may be the root causes of inflammation > __http://en.wikipediahttp://en.http://en.wi_ (http://en.wikipedia.org/wiki/Interleukin_) > (_http://en.wikipediahttp://en.http://en.w_ (http://en.wikipedia.org/wiki/Interleukin) ) > __http://www.lef.http://www.lefhttp://wwwhttp:/_ (http://www.lef.org/protocols/prtcl-146.shtml_) > (_http://www.lef.http://www.lefhttp://wwwhttp:_ (http://www.lef.org/protocols/prtcl-146.shtml) ) > > In a message dated 07/02/07 5:22:03 PM Pacific Daylight Time, > yildiz22@... writes: > > > > > Thank you for your answer.Could it be that you have an overall inflammation > but damage is more in the brain?As you might remember I also have the same > problem and gives me very hard time lately. For the last three days I also > started to get very slight strange smell and taste. I think some seizure > type activity is developing. I am afraid this inflammation is damaging my > brain.I think vit D helps.Have you taken saliva cortisol test?Could you > below in cortisol? I am telling you this but I am on 20 mg HC eq. of > isocort. This is the top dosage. Don't know what else I can do? strange thing > is that mine is on the left side only? > bw > nil > > > > > ************************************** See what's free at http://www.aol.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 7, 2007 Report Share Posted July 7, 2007 Do you mean these cytokine tests have to be done at specialty labs? Would the Stanford lab do them, you think? Katrina > > > > While more specific than a generalized marker of inflammation as with the > CRP test, it appears as shown in bold below that elevated cytokine levels can > pinpoint at least a group of certain causes of inflammation: > Interleukin-1 beta (IL-1b) > This test is used to identify elevated levels of Interleukin-1 beta. IL-1b > is a cytokine produced principally by mononuclear phagocytes but also by > various other cells types including keratinocytes, epithelium and cells of the > CNS. Elevated levels of Interleukin-1 beta have been implicated in sepsis, > cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, > inflammatory bowel disease, anorexia, AIDS, and graft-versus-host disease > associated with bone marrow transplants. IL-1B is one of the key mediators of > immunobiological responses to physical stress, a pilot study showed that higher > levels were associated with anxiety/panic disorder. Higher than normal levels > have also been associated with a significant increased risk of myocardial > infarction independent of Cardio-CRP levels. > > Interleukin-6 (IL-6) > This test is used to identify elevated levels of Interleukin-6. IL-6 is a > cytokine produced by many different cells including monocytes/macrophages, > fibroblasts, endothelial cells, keratinocytes, mast cells, T cells and many tumor > cell lines. Elevated IL-6 serum or plasma levels may occur in different > conditions including sepsis, autoimmune diseases, lymphomas, AIDS, alcoholic > liver disease, tumor development, Alzheimer’s disease, and in c with infections > or transplant rejection. Elevated levels of IL-6 may be associated with an > increased risk of heart attack, and stroke. > > Interleukin-8 (IL-8) > This test is used to identify elevated levels of Interleukin-8. IL-8 is > produced by stimulated monocytes, macrophages, fibroblasts, endothelial cells, > keratinocytes, melanocytes, hepatocytes, chondrocytes, and a number of tumor > cell lines. In many types of cells the synthesis of IL8 is strongly stimulated > by IL1 and TNF-alpha. Elevated concentrations are observed in psoriasis > rheumatoid arthritis, chronic polyarthritis, tumor development and Hepatitis C. > Tumor necrosis factor alpha (TNF-a) > This test is used to identify elevated levels of Tumor necrosis factor > alpha. A variety of cells are shown to produce TNF- .TNF- is a growth factor for > fibroblasts and stimulates the synthesis of collagenase and prostaglandin E2. > Bone resorption can be induced by TNF- because it activates osteoclasts. TNF- > enhances the proliferation of T cells after stimulation with IL-2. In the > absence of IL-2, TNF- induces the proliferation and differentiation of beta > cells. TNF- levels may be elevated in sepsis, cachexia, AIDS, Hepatitis C, > transplant rejection, various infectious and autoimmune diseases. > > Just having an infection like Lyme, HHV6, EBV, CMV, etc. alone can elevate > cytokines which, in turn, elevate your CRP and make one higher risk for other > degenerative diseases. At the very least, you would know which cytokines are > elevated that are the more (or less) potentially life-threatening down the > pike. It's also another way to challenge the accuracy of the CRP test. I just > figure that the more data one is equipped with, the closer to final resolution. > > In a message dated 07/05/07 1:17:35 PM Pacific Daylight Time, pj7@... > writes: > > Would you please explain how finding which cytokines are elevated > would reveal the cause of the inflammation? > > Thanks, > a Carnes > > > > > > > Starting with the CRP first to see if you're elevated is the best > way to go, > > and if you are, then I would test on as many pro-inflammatory > cytokines as > > much as possible to try and find the cause of the infllammation: > TNF-alpha, > > Il-6, 8, 12, etc. These can be done through 3 sources I located: > > > > Life Extension Foundation has their own panel for covenience, > although it > > isn't covered by insurance, and is actually done at LabCorp. > > __http://www.lef.http://www.lhttp://www.lef.http:_ > (http://www.lef.org/newshop/items/itemLCCYT.html_) > > (_http://www.lef.http://www.lhttp://www.lef.http_ > (http://www.lef.org/newshop/items/itemLCCYT.html) ) > > > > LabCorp - you have to order them separately > > > > Specialty Labs - order separately > > > > Cytokines do, in fact, pinpoint what may be the root causes of > inflammation > > __http://en.wikipediahttp://en.http://en.wi_ > (http://en.wikipedia.org/wiki/Interleukin_) > > (_http://en.wikipediahttp://en.http://en.w_ > (http://en.wikipedia.org/wiki/Interleukin) ) > > __http://www.lef.http://www.lefhttp://wwwhttp:/_ > (http://www.lef.org/protocols/prtcl-146.shtml_) > > (_http://www.lef.http://www.lefhttp://wwwhttp:_ > (http://www.lef.org/protocols/prtcl-146.shtml) ) > > > > In a message dated 07/02/07 5:22:03 PM Pacific Daylight Time, > > yildiz22@ writes: > > > > > > > > > > Thank you for your answer.Could it be that you have an overall > inflammation > > but damage is more in the brain?As you might remember I also have > the same > > problem and gives me very hard time lately. For the last three days > I also > > started to get very slight strange smell and taste. I think some > seizure > > type activity is developing. I am afraid this inflammation is > damaging my > > brain.I think vit D helps.Have you taken saliva cortisol test?Could > you > > below in cortisol? I am telling you this but I am on 20 mg HC eq. > of > > isocort. This is the top dosage. Don't know what else I can do? > strange thing > > is that mine is on the left side only? > > bw > > nil > > > > > > > > > > > > > > > > > > ************************************** See what's free at http://www.aol.com. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 7, 2007 Report Share Posted July 7, 2007 Even if you decide to do all those tests, you may want to consider looking at possible simple factors that can cause elevated CRP, like being overweight, having insulin resistance, low physical activity, low fiber, and low magnesium. These are some factors which I found to be associated with elevated CRP, by doing a quick scan of PUBMED. - Mark > > > > > > > > While more specific than a generalized marker of inflammation as with the > > CRP test, it appears as shown in bold below that elevated cytokine levels can > > pinpoint at least a group of certain causes of inflammation: > > Interleukin-1 beta (IL-1b) > > This test is used to identify elevated levels of Interleukin-1 beta. IL-1b > > is a cytokine produced principally by mononuclear phagocytes but also by > > various other cells types including keratinocytes, epithelium and cells of the > > CNS. Elevated levels of Interleukin-1 beta have been implicated in sepsis, > > cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, > > inflammatory bowel disease, anorexia, AIDS, and graft-versus- host disease > > associated with bone marrow transplants. IL-1B is one of the key mediators of > > immunobiological responses to physical stress, a pilot study showed that higher > > levels were associated with anxiety/panic disorder. Higher than normal levels > > have also been associated with a significant increased risk of myocardial > > infarction independent of Cardio-CRP levels. > > > > Interleukin-6 (IL-6) > > This test is used to identify elevated levels of Interleukin-6. IL-6 is a > > cytokine produced by many different cells including monocytes/macrophages, > > fibroblasts, endothelial cells, keratinocytes, mast cells, T cells and many tumor > > cell lines. Elevated IL-6 serum or plasma levels may occur in different > > conditions including sepsis, autoimmune diseases, lymphomas, AIDS, alcoholic > > liver disease, tumor development, Alzheimer’s disease, and in c with infections > > or transplant rejection. Elevated levels of IL-6 may be associated with an > > increased risk of heart attack, and stroke. > > > > Interleukin-8 (IL-8) > > This test is used to identify elevated levels of Interleukin-8. IL-8 is > > produced by stimulated monocytes, macrophages, fibroblasts, endothelial cells, > > keratinocytes, melanocytes, hepatocytes, chondrocytes, and a number of tumor > > cell lines. In many types of cells the synthesis of IL8 is strongly stimulated > > by IL1 and TNF-alpha. Elevated concentrations are observed in psoriasis > > rheumatoid arthritis, chronic polyarthritis, tumor development and Hepatitis C. > > Tumor necrosis factor alpha (TNF-a) > > This test is used to identify elevated levels of Tumor necrosis factor > > alpha. A variety of cells are shown to produce TNF- .TNF- is a growth factor for > > fibroblasts and stimulates the synthesis of collagenase and prostaglandin E2. > > Bone resorption can be induced by TNF- because it activates osteoclasts. TNF- > > enhances the proliferation of T cells after stimulation with IL- 2. In the > > absence of IL-2, TNF- induces the proliferation and differentiation of beta > > cells. TNF- levels may be elevated in sepsis, cachexia, AIDS, Hepatitis C, > > transplant rejection, various infectious and autoimmune diseases. > > > > Just having an infection like Lyme, HHV6, EBV, CMV, etc. alone can elevate > > cytokines which, in turn, elevate your CRP and make one higher risk for other > > degenerative diseases. At the very least, you would know which cytokines are > > elevated that are the more (or less) potentially life- threatening down the > > pike. It's also another way to challenge the accuracy of the CRP test. I just > > figure that the more data one is equipped with, the closer to final resolution. > > > > In a message dated 07/05/07 1:17:35 PM Pacific Daylight Time, pj7@ > > writes: > > > > Would you please explain how finding which cytokines are elevated > > would reveal the cause of the inflammation? > > > > Thanks, > > a Carnes > > > > > > > > > > > Starting with the CRP first to see if you're elevated is the best > > way to go, > > > and if you are, then I would test on as many pro-inflammatory > > cytokines as > > > much as possible to try and find the cause of the infllammation: > > TNF-alpha, > > > Il-6, 8, 12, etc. These can be done through 3 sources I located: > > > > > > Life Extension Foundation has their own panel for covenience, > > although it > > > isn't covered by insurance, and is actually done at LabCorp. > > > __http://www.lef.http://www.lhttp://www.lef.http:_ > > (http://www.lef.org/newshop/items/itemLCCYT.html_) > > > (_http://www.lef.http://www.lhttp://www.lef.http_ > > (http://www.lef.org/newshop/items/itemLCCYT.html) ) > > > > > > LabCorp - you have to order them separately > > > > > > Specialty Labs - order separately > > > > > > Cytokines do, in fact, pinpoint what may be the root causes of > > inflammation > > > __http://en.wikipediahttp://en.http://en.wi_ > > (http://en.wikipedia.org/wiki/Interleukin_) > > > (_http://en.wikipediahttp://en.http://en.w_ > > (http://en.wikipedia.org/wiki/Interleukin) ) > > > __http://www.lef.http://www.lefhttp://wwwhttp:/_ > > (http://www.lef.org/protocols/prtcl-146.shtml_) > > > (_http://www.lef.http://www.lefhttp://wwwhttp:_ > > (http://www.lef.org/protocols/prtcl-146.shtml) ) > > > > > > In a message dated 07/02/07 5:22:03 PM Pacific Daylight Time, > > > yildiz22@ writes: > > > > > > > > > > > > > > > Thank you for your answer.Could it be that you have an overall > > inflammation > > > but damage is more in the brain?As you might remember I also have > > the same > > > problem and gives me very hard time lately. For the last three days > > I also > > > started to get very slight strange smell and taste. I think some > > seizure > > > type activity is developing. I am afraid this inflammation is > > damaging my > > > brain.I think vit D helps.Have you taken saliva cortisol test? Could > > you > > > below in cortisol? I am telling you this but I am on 20 mg HC eq. > > of > > > isocort. This is the top dosage. Don't know what else I can do? > > strange thing > > > is that mine is on the left side only? > > > bw > > > nil > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ************************************** See what's free at http://www.aol.com. > > > > > > Quote Link to comment Share on other sites More sharing options...
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