Vaccine-associated immune-mediated hemolytic anemia in the dog.

[Guest guest]

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1090453

Vaccine-associated immune-mediated hemolytic anemia in the dog.

Duval D, Giger U.

Department of Clinical Studies, School of Veterinary Medicine, University

of Pennsylvania, Philadelphia 19104-6010, USA.

Vaccination has been incriminated as a trigger of immune-mediated

hemolytic anemia (IMHA) in dogs and in people, but evidence to support this

association is lacking. In a controlled retrospective study, idiopathic IMHA

was identified in 58 dogs over a 27-month period. When compared with a

randomly selected control group of 70 dogs (presented for reasons other than

IMHA) over the same period, the distribution of cases versus time since

vaccination was different (P < .05). Fifteen of the dogs (26%) had been

vaccinated within 1 month (mean, 13 days; median, 14 days; range, 1 to 27

days) of developing IMHA (P < .0001), whereas in the control group no marked

increase in frequency of presentation was seen in the first month after

vaccination. The dogs with IMHA were divided into 2 groups based on time

since vaccination: the vaccine IMHA group included dogs vaccinated within 1

month of developing IMHA; the nonvaccine IMHA group included dogs that

developed IMHA more than 1 month after vaccination. The recently vaccinated

dogs with IMHA (vaccine IMHA group) had significantly lower platelet counts

(P < .05) and a trend towards increased prevalence of intravascular

hemolysis and autoagglutination when compared with the nonvaccine IMHA

group. Similar mortality rates were seen in teh vaccine IMHA group (60%) and

the nonvaccine IMHA group (44%), with the majority of fatalities (> 75%)

occurring in the first 3 weeks after presentation. Persistent

autoagglutination was a negative prognostic indicator for survival in both

groups (P < .05). Presence of icterus and hyperbilirubinemia were negative

prognostic indicators for survival in the nonvaccine IMHA group (P < .0001

and P < .01, respectively) but not in the vaccine IMHA group. In the

recently vaccinated dogs, combination vaccines from various manufacturers

against canine distemper, adenovirus type 2, leptospirosis, parainfluenza,

and parvovirus (DHLPP) were involved in each case. Vaccines against rabies

virus, Bordetella spp, coronavirus, and Lyme Borrelia were administrated

concomitantly to some dogs. This study provides the first clinical evidence

for a temporal relationship of vaccine-associated IMHA in the dog.

PMID: 8884713 [PubMed - indexed for MEDLINE]

--------------------------------------------------------

Sheri Nakken, R.N., MA, Hahnemannian Homeopath

Vaccination Information & Choice Network, Nevada City CA & Wales UK

$$ Donations to help in the work - accepted by Paypal account

earthmysteriestours@... voicemail US 530-740-0561

(go to http://www.paypal.com) or by mail

Vaccines - http://www.nccn.net/~wwithin/vaccine.htm

Vaccine Dangers On-Line course - http://www.nccn.net/~wwithin/vaccineclass.htm

Reality of the Diseases & Treatment -

http://www.nccn.net/~wwithin/vaccineclass.htm

Homeopathy On-Line course - http://www.nccn.net/~wwithin/homeo.htm