Guest guest Posted December 31, 2006 Report Share Posted December 31, 2006 Looking at Parkinson's Disease info got me thinking that maybe Parkinson's (also an SNP-linked condition, BTW) is, like Autism, a specific analog to the underlying type of dysfunction found in CFS. It's a conjecture strengthened by recent apparent successes in CFS with dopamine boosters. What really got my attention though, is that the impaired part of the brain in PD, the substantia nigra, is among the basal ganglia, and they have shown a hypoperfusion of blood in CFIDS, no?. And depression does not show a hypoperfusion there--is that right?? Among the three neurological impairments of PD, there is one I feel I have in spades. Described in one article, like this: " Bradykinesia...is a difficulty INITIATING VOLUNTARY MOVEMENT, as though the brake cannot be released. " Maybe we lack the effective preparatory pre-picturing of actions, which is dependent on the basal ganglia, and is required before an action can be externalized in the body. To me, it is not so much like the _brake_ being set as like the _clutch_ being disengaged. I think this may be the " staring " state PWCs have described (like I'm sitting _way_ back inside my body, looking out through the wrong end of a telescope, and to come all the way forward and do something is unimaginable. This immobilization is on top off the mitochondrial fatigue, or it could be a defense against pre-picturing things the mitochondria are not equipped to enact. Anyhow, it is a different kind of immobilization, which is widely misunderstood, even by ourselves sometimes, when characterized simply as fatigue. -- Quote Link to comment Share on other sites More sharing options...
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