Re: Confused about high RBC and high Serum Folate

[Guest guest]

Hi, Sue.

Abnormally high RBC levels is atypical for PWCs, which is concerning and may

indicate

something else has developed. Here is a Mayo Clinic link with a list of common

causes for

this condition that you may want to consider along with your folate question

which I don't

have an answer:

http://www.mayoclinic.com/health/high-red-blood-cell-count/AN00490/

" Sue T " <morabshadow@...> wrote:

>

> High Rich, and all,

>

> Can you help explain what may be going on with my folate levels?

>

> Could it possibly be that my very high (off the charts)RBC levels still

> means that I have not coverted to the correct type of folate?

>

> In other words how do I know my if the RBC levels are the correct type

> of folate?

>

> My MCV blood cell levels are still high normal to high in reference

> range, low ferrtin, normal Methylmalonic acid(slightly high normal)

> doing .2 ml methyl b12 every other day plus various oral B12s on off

> days.

>

> Thanks and best wishes,

> Sue T

>

[Guest guest]

HI ,

Thanks for your reply.

I am sorry I was not clear. I meant to say the " high Folate RBC count " not

high RBC count.I was wondering if the High RBC Folate count was acutally a

measurement of the L-5-tetrahydrofolate.

To make it simple ; Is a high RBC Folate count a measurement of

L-5-tetrahydrofolate(the kind we need) or some other folate. Not sure why I have

such " off the charts " high RBC folate.

Sorry to be confusing . . a little nervous since I have an Endomentrial

Ablation and General anesthesia scheduled in two days for the heavy bleeding and

Kaiser is driving me CRAZY!! I am also wating for results from a D & C for

endrometrial cancer today, too.

Sue T

davidhall2020 <david-hall@...> wrote:

Hi, Sue.

Abnormally high RBC levels is atypical for PWCs, which is concerning and may

indicate

something else has developed. Here is a Mayo Clinic link with a list of common

causes for

this condition that you may want to consider along with your folate question

which I don't

have an answer:

http://www.mayoclinic.com/health/high-red-blood-cell-count/AN00490/

" Sue T " <morabshadow@...> wrote:

>

> High Rich, and all,

>

> Can you help explain what may be going on with my folate levels?

>

> Could it possibly be that my very high (off the charts)RBC levels still

> means that I have not coverted to the correct type of folate?

>

> In other words how do I know my if the RBC levels are the correct type

> of folate?

>

> My MCV blood cell levels are still high normal to high in reference

> range, low ferrtin, normal Methylmalonic acid(slightly high normal)

> doing .2 ml methyl b12 every other day plus various oral B12s on off

> days.

>

> Thanks and best wishes,

> Sue T

>

[Guest guest]

Hi Sue,

Sorry I can't help with your query. I just wanted to say I'm

thinking of you and *really* wishing you the best possible outcome

from your op and investiagtions.

XX

> >

> > High Rich, and all,

> >

> > Can you help explain what may be going on with my folate levels?

> >

> > Could it possibly be that my very high (off the charts)RBC levels

still

> > means that I have not coverted to the correct type of folate?

> >

> > In other words how do I know my if the RBC levels are the correct

type

> > of folate?

> >

> > My MCV blood cell levels are still high normal to high in

reference

> > range, low ferrtin, normal Methylmalonic acid(slightly high

normal)

> > doing .2 ml methyl b12 every other day plus various oral B12s on

off

> > days.

> >

> > Thanks and best wishes,

> > Sue T

> >

>

>

>

>

>

>

>

[Guest guest]

Hi ,

Thanks for your kind words and wishes. . . it really helps!

I wish the best for you, too especially during this hoilday season.

Sue T

Hi Sue,

Sorry I can't help with your query. I just wanted to say I'm

thinking of you and *really* wishing you the best possible outcome

from your op and investiagtions.

XX

[Guest guest]

Hi, Sue.

Sounds like your plate is really full right now. You have my

prayers for good D & C results and also for the endometrial ablation

prodecure under general anesthesia.

With regard to the forms of folate in the blood, here's what is says

in Henry, J.B., Clinical Diagnosis and Management by Laboratory

Methods, 20th ed., 2001, p. 549:

" Unlike serum folate (which is entirely 5-methyltetrahydrofolate),

red cell folates are a heterogeneous mixture of different forms with

varying polyglutamate chain lengths, which pose challenges to

nonmicrobiological assays. "

I'm not sure what's going on with your high RBC folate level, but

one possibility would be a folate trap mechanism. The idea there is

that if the operation of the methionine synthase enzyme is lower

than normal, more and more folate gets converted into

methyltetrahydrofolate, and it just keeps building up, because the

only reaction that uses it is the methionine synthase reaction, and

it's going too slow. As you know, this reaction also needs

methycobalamin, and a common cause of a folate trap mechanism is a

deficiency of B12. I think another possibility would be mercury

toxicity, because, according to Prof. Deth, mercury blocks the

formation of methylcobalamin.

I understand that you are supplementing methylcobalamin and other

forms of B12, so it would seem that you have that possibility

covered.

Are you taking various forms of folate supplements also, such as

FolaPro, folinic, and folic?

Sorry I'm not able to participate on the list as much as I'd like.

Working on deadlines for papers, and also my mother-in-law is in

hospice care now, and, of course, we don't know how long she will

live, so things are kind of uncertain right now around here.

I wish you the best for your upcoming procedure.

Rich

> >

> > High Rich, and all,

> >

> > Can you help explain what may be going on with my folate levels?

> >

> > Could it possibly be that my very high (off the charts)RBC

levels still

> > means that I have not coverted to the correct type of folate?

> >

> > In other words how do I know my if the RBC levels are the

correct type

> > of folate?

> >

> > My MCV blood cell levels are still high normal to high in

reference

> > range, low ferrtin, normal Methylmalonic acid(slightly high

normal)

> > doing .2 ml methyl b12 every other day plus various oral B12s on

off

> > days.

> >

> > Thanks and best wishes,

> > Sue T

> >

>

>

>

>

>

>

>