Yet another study showing measles disease protects against asthma

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J Allergy Clin Immunol 2002 Jun;109(6 Pt 2):525S-32S

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Environmental factors influencing the development and progression of

pediatric asthma.

Von Mutius E.

Ludwig Maximilian University Children's Hospital, Munich, Germany.

Recent data underscore the importance of environmental factors in the

sensitization of children to certain allergens and the development of

asthma. Maternal smoking and family (especially maternal) history of

atopy appear to be risk factors for persistent sensitization and

development of asthma. Indeed, exposure to tobacco smoke in utero

significantly increases asthma risk and influences the timing of

sensitization. It must be stated that any smoking at home has

consequences for the development of asthma and other respiratory

conditions. In addition, reports of possible protective effects of

specific environmental conditions suggest that exposure to certain

stimuli may reduce or block the development and progression of asthma.

Attendance at a day care center early in life appears to offer

protective effects against wheezing, as do early episodes of rhinitis,

herpes, and measles. Children raised on a farm also have a decreased

prevalence of atopic diseases. The protective effect of contact with

livestock and poultry is consistent among several studies. Although the

pathophysiologic mechanisms involved remain undefined, studies suggest

that exposure to endotoxin and other components of bacteria may play an

important role in protecting against childhood atopic diseases. Whether

in utero exposure is beneficial remains to be determined.

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Vaccination Information & Choice Network, Nevada City CA & Wales UK

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