Re: The Krebs cycle

[Guest guest]

interesting.. can i ask how much it was and whether insurance paid.. and what

treatments you will use now .. u have ur results?

louela

alwaysacutie2u <jgstev716@...> wrote:

HI All,

Just a heads up. I just had a Metabolic Analysis Profile from Genova

Diagnostics, which showed me my Krebs cycle. In fours areas I a

virtually flat. This would explain my great fatigue. I do not have

any " brain stuff " going on except I can't think when I crash.

If this decribes you, I would suggest, you take a look at this test.

Janet

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[Guest guest]

I put this thru Medicare. I think they will pay for it. The Krebs cycle can be

supplemented. ATP, carnitine, Vit E succinate, NADH, Krebs Zinc, Krebs

Mag/Posssium and so forth. It is like a circle. To know where you are broken

down and need help, you need to look.

Janet

louella monrovia <lmonrovia@...> wrote:

interesting.. can i ask how much it was and whether insurance paid..

and what treatments you will use now .. u have ur results?

louela

alwaysacutie2u <jgstev716@...> wrote:

HI All,

Just a heads up. I just had a Metabolic Analysis Profile from Genova

Diagnostics, which showed me my Krebs cycle. In fours areas I a

virtually flat. This would explain my great fatigue. I do not have

any " brain stuff " going on except I can't think when I crash.

If this decribes you, I would suggest, you take a look at this test.

Janet

---------------------------------

Cheap Talk? Check out Messenger's low PC-to-Phone call rates.

[Guest guest]

Hi, all.

Here's a repost from the cfs_yasko group, in case there are some

here, but not there, who are interested.

Hi, Janet.

Thank you for faxing me the results of your recent Metabolic

Analysis Profile (MAP) and your Urine Amino Acids (UAA) test.

I have studied these results, and here are my conclusions:

As you know, your Nutrigenomics results showed that you have both

CBS A360A (+/+) and SUOX S370S (+/-), and that in response to Dr.

Amy's recommendations, you undertook the ammonia support program,

which involved decreasing your intake of protein to decrease the

production of ammonia, sulfite and hydrogen sulfide, and also taking

supplements directed toward binding ammonia in the gut and taking it

out in the stools. Judging from the low levels of ammonia and

taurine in your UAA results, you have been successful in

accomplishing these things.

As you also know, you have struggled with a long history of gut

problems, including yeast infection and bacterial dysbiosis. These

recent test results provide considerable evidence that these

problems are continuing. When there is severe dysbiosis in the

small intestine, the result is that the food is not properly

digested and absorbed, but instead is broken down by the bacteria

and yeasts in the gut, producing gas and various metabolites that

show up as organic acids in the urine, and some of them can be

deleterious.

Looking at all your test results together, it appears that as a

result of the dysbiosis, and perhaps also partially as a result of

your intentionally restricted dietary protein, the amounts of amino

acids that are being absorbed into your body from the gut are too

low to supply your body's needs. This is having several effects.

One is that your muscles are breaking down their protein faster than

normal to try to supply amino acids for the rest of the body.

Another is that the levels of amino acids coming out in your urine

are nearly all below normal, suggesting that your blood plasma

levels of amino acids may also be somewhat low. Since the Krebs

cycle intermediates are normally maintained at normal levels by

anaplerosis, which involves use of amino acids to build them up, and

since your blood plasma amino acids are likely low, based on the

urine amino acids levels, I suspect that there is not enough of them

available to keep the Krebs intermediates in their normal ranges.

The Krebs cycle normally accepts acetyl Co A made from pyruvate from

the metabolism of carbohydrates by the glycolysis pathway, and also

made from fatty acids as a result of beta oxidation. Because the

Krebs cycle intermediates are so badly depleted, this cycle is not

able to accept the contributionss from either the carbohydrate or

the fatty acid fuels. When the normal fatty acid metabolism is

blocked, the result is that the fatty acids are diverted to omega

oxidation instead of beta oxidation. That's what is happening in

your body, based on the test results. The result of all of this is

that the production of ATP by the mitochondria of your cells is far

below normal, and this is responsible for your muscle fatigue as

well as various problems in other types of cells.

When the Krebs cycles are unable to produce ATP at normal rates, the

fallback mechanism in the cells is to upregulate the glycolysis

pathways, which metabolize carbohydrates and produce pyruvate and

lactate. This can make up for some of the ATP deficit, though it is

not very efficient. When this happens, one would expect to see

elevated pyruvate and lactate. However, in your case, these are

both low-normal. I think this suggests that the glycolysis pathways

are running slower than normal also, in your case, and that this

suggests that the absorption of carbohydrates by your gut may be

impaired, just as the absorption of protein appears to be. This may

be a result of the yeast infection, since yeasts metabolize

carbohydrates. The upshot of all of this is that your available

supply of energy in the form of ATP is very low compared to normal.

So, what should be done? I think that the main focus in your case

needs to be improving the condition and operation of your digestive

system, i.e. the stomach and the gut. I know that you have made

many efforts in the past to do this, but the problems still remain.

I think the first step should be to get more information about

what's going on in the digestive system, and I'm glad that you have

a Comprehensive Diagnostic Stool Analysis (CDSA) in the works,

because that should help in figuring out what the issues are. When

the results come back, we should be in a better position to figure

out a treatment approach for your digestive system.

I suspect that it is going to take a comprehensive approach to set

things right there, and I know that you have tried many things

before, but I'm hopeful that with the additional information from

the CDSA it will be clearer what should be done.

In the meantime, I think that increasing your intake of branched-

chain amino acids may help to raise the amounts of amino acids that

are absorbed into your body, and the other supplements suggested by

Dr. Amy, many of which you were already taking, should help, also.

In response to your question about citric acid, yes, I think that

taking it could be beneficial, along with the other supplements for

Krebs cycle support. You might consider taking magnesium citrate,

since that would kill two birds with one stone, since magnesium

appears to be low. You also asked about taking supplementary

phosphate. Usually there is enough phosphate in the diet to supply

the body's needs. I think the people who take it supplementally are

athletes who push their bodies beyond the normal. As far as I know,

extra phosphate should not be necessary for you. Also, I don't know

whether you are taking curcumin, or whether you can tolerate it, but

it might be helpful, too, since it will encourage the production of

glutathione, which is low in your case, from cysteine, which is

somewhat elevated. If you can tolerate turmeric in your food, that

contains curcumin.

Rich

>

> HI All,

>

> Just a heads up. I just had a Metabolic Analysis Profile from

Genova

> Diagnostics, which showed me my Krebs cycle. In fours areas I a

> virtually flat. This would explain my great fatigue. I do not have

> any " brain stuff " going on except I can't think when I crash.

>

> If this decribes you, I would suggest, you take a look at this

test.

>

> Janet

>