Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Hi Adrienne, I came up with normal glutathione too and Rich suggested testing to see if my glutathione peroxidase enzyme was working properly, and it wasn't. Glutathione peroxidase enables glutathione to convert hydrogen peroxide to water.So even if your glutathione levels are normal you may not be able to use it effectively if this enzyme isn't working properly. Rich also suggested getting the glutathione-s-transferase enzymes tested. These enzymes helps your liver to detoxify heavy metals and chemicals. So if these enzymes aren't working properly you get similar effects to not having enough glutathione because the glutathione can't be used effectively. Hope this makes some sense, please anyone correct me if I have got this wrong. BW, Sheila > > I hate to bother anyone,( especially you, Rich), but I am kind of in a stuck place, now that my test results have come back and my glutathione level is apparently ok. > I remember Rich saying there was the possibility that even if GSH is replete there might be a blockage preventing its use. > I have tried to research the archive (on my desktop) for this post, but I am incapable of doing that. > What sort of block could that be and what would be the work-around? > Thanks, in advance. > Adrienne > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Sheila, Thanks! with those enzyme names I was able to track it down. So, where do I get those two things tested? (Was it expensive?) But even more, what recommendations were you given to correct those problems. When feasible I like to experiment with the solution rather than spend money for tests. Thanks, Adrienne Re: Rich and all, re: RBC glut Hi Adrienne, I came up with normal glutathione too and Rich suggested testing to see if my glutathione peroxidase enzyme was working properly, and it wasn't. Glutathione peroxidase enables glutathione to convert hydrogen peroxide to water.So even if your glutathione levels are normal you may not be able to use it effectively if this enzyme isn't working properly. Rich also suggested getting the glutathione-s-transferase enzymes tested. These enzymes helps your liver to detoxify heavy metals and chemicals. So if these enzymes aren't working properly you get similar effects to not having enough glutathione because the glutathione can't be used effectively. Hope this makes some sense, please anyone correct me if I have got this wrong. BW, Sheila > > I hate to bother anyone,( especially you, Rich), but I am kind of in a stuck place, now that my test results have come back and my glutathione level is apparently ok. > I remember Rich saying there was the possibility that even if GSH is replete there might be a blockage preventing its use. > I have tried to research the archive (on my desktop) for this post, but I am incapable of doing that. > What sort of block could that be and what would be the work-around? > Thanks, in advance. > Adrienne > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Hi Adrienne, Well I am in the UK, but perhaps you are in the US? Over here the tests were done at Biolab in London. The glutathione peroxidase test costs about £19 $13) and I think the glutathione transferase test was approx £28($19) or you can get it as part of the toxic screen test which is a fancy sensitive liver test costing about £58($39). If you are in the US perhaps someone can chime in here with the info on labs aand these tests. If you have low glutathione peroxidase, my doc said it can be due to 3 things, 1. low glutathione - well you've not got that 2. selenium deficiency 3. genetic variants of the enzyme that don't work so well - Rich said that some of these variants work more efficiently with increased selenium intake though. Selenium can be toxic in large doses. I am on 800mcg, this is a high dose, prescribed by the doc, for 2 months to see how the levels of the enzyme increase, or not. Then the dose will be reviewed. I don't think I'd want to carry on at this dose longterm without the docs OK. I think the recommended max dose is normally about 400mcg. I had been on 200mcg for years but still seem to have been low. If you read this article http://tinyurl.com/g7dbg you will see that methylselenomethionine seems to be thought of as the best form and the easiest for your body to detoxify. Jarrow (activated selenium), Solaray, Ecological Formulas and Vitamin Research Products seem to make selenium supplements in that form that form. Brazil nuts are also a very good soource of selenium and brazil nut oil. Sorry I don't know what the treatment would be if you had glutathione-s-transferase problems. Do you have lyme? I case it might be relevent, Rich wrote a post on his theory of how lyme disease becomes chronic. I can't find the original but you can read it at message number 106236. If you read it you will see how it fits in with glutathione peroxidase and selenium. BW, Sheila > > > > I hate to bother anyone,( especially you, Rich), but I am kind of in > a stuck place, now that my test results have come back and my > glutathione level is apparently ok. > > I remember Rich saying there was the possibility that even if GSH is > replete there might be a blockage preventing its use. > > I have tried to research the archive (on my desktop) for this post, > but I am incapable of doing that. > > What sort of block could that be and what would be the work-around? > > Thanks, in advance. > > Adrienne > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Hi BW, Would you tell me where you got your glutathione peroxidase enzyme test? Thanks. Edy Re: Rich and all, re: RBC glut Hi Adrienne, I came up with normal glutathione too and Rich suggested testing to see if my glutathione peroxidase enzyme was working properly, and it wasn't. Glutathione peroxidase enables glutathione to convert hydrogen peroxide to water.So even if your glutathione levels are normal you may not be able to use it effectively if this enzyme isn't working properly. Rich also suggested getting the glutathione-s-transferase enzymes tested. These enzymes helps your liver to detoxify heavy metals and chemicals. So if these enzymes aren't working properly you get similar effects to not having enough glutathione because the glutathione can't be used effectively. Hope this makes some sense, please anyone correct me if I have got this wrong. BW, Sheila > > I hate to bother anyone,( especially you, Rich), but I am kind of in a stuck place, now that my test results have come back and my glutathione level is apparently ok. > I remember Rich saying there was the possibility that even if GSH is replete there might be a blockage preventing its use. > I have tried to research the archive (on my desktop) for this post, but I am incapable of doing that. > What sort of block could that be and what would be the work-around? > Thanks, in advance. > Adrienne > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Hi Adrienne This summer I had 2 glutathione tests done by the UK's Biolab: RBC glutathione: June 1.47 (ref: 1.7 - 2.6 umol/l) Sept 1.87 Red cell glutathione-S-transferase: June 179 (ref: 68 - 167 units) JMH notes: One discrete enzyme band accounts for 35% of the total. Atomic emission analysis of the eluted abnormal enzyme demonstrates the presence of nickel. Sept 152 JMH notes: There is a *faint* race of a discrete enzyme band. ? Past exposure to a toxic metal. The level is too low for identification of the causative substance (probably a metal). So in 3 months it appears that my glutathione levels have come up to normal and the nickel problem that was affecting the glutathione-s-transferase has significantly reduced. The only changes I've made to my routine that I consider may be significant are starting Lipoceutical Glutathione and FIR saunas soon after the first test. Sue Adrienne G. wrote: > Sheila, Thanks! with those enzyme names I was able to track it down. > So, where do I get those two things tested? (Was it expensive?) > But even more, what recommendations were you given to correct those > problems. When feasible I like to experiment with the solution rather > than spend money for tests. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Sue wot kind of lipoceutical glut do u use? IS it essential GSh or something you get closer to home ? and wot kind of doses do u use? Tnx Louella Recent Activity 19 New Members Visit Your Group Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 Thanks, . My RBC glutathione is already normal. I am inquiring about testing the enzymes because I have been told they might inhibit my ability to utilize the glutathione. Adrienne Re: Rich and all, re: RBC glut Hi Adrienne This summer I had 2 glutathione tests done by the UK's Biolab: RBC glutathione: June 1.47 (ref: 1.7 - 2.6 umol/l) Sept 1.87 Red cell glutathione-S-transferase: June 179 (ref: 68 - 167 units) JMH notes: One discrete enzyme band accounts for 35% of the total. Atomic emission analysis of the eluted abnormal enzyme demonstrates the presence of nickel. Sept 152 JMH notes: There is a *faint* race of a discrete enzyme band. ? Past exposure to a toxic metal. The level is too low for identification of the causative substance (probably a metal). So in 3 months it appears that my glutathione levels have come up to normal and the nickel problem that was affecting the glutathione-s-transferase has significantly reduced. The only changes I've made to my routine that I consider may be significant are starting Lipoceutical Glutathione and FIR saunas soon after the first test. Sue Adrienne G. wrote: > Sheila, Thanks! with those enzyme names I was able to track it down. > So, where do I get those two things tested? (Was it expensive?) > But even more, what recommendations were you given to correct those > problems. When feasible I like to experiment with the solution rather > than spend money for tests. This list is intended for patients to share personal experiences with each other, not to give medical advice. If you are interested in any treatment discussed here, please consult your doctor. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2006 Report Share Posted October 13, 2006 , I forgot;can you feel any difference? Adrienne Re: Rich and all, re: RBC glut Hi Adrienne This summer I had 2 glutathione tests done by the UK's Biolab: RBC glutathione: June 1.47 (ref: 1.7 - 2.6 umol/l) Sept 1.87 Red cell glutathione-S-transferase: June 179 (ref: 68 - 167 units) JMH notes: One discrete enzyme band accounts for 35% of the total. Atomic emission analysis of the eluted abnormal enzyme demonstrates the presence of nickel. Sept 152 JMH notes: There is a *faint* race of a discrete enzyme band. ? Past exposure to a toxic metal. The level is too low for identification of the causative substance (probably a metal). So in 3 months it appears that my glutathione levels have come up to normal and the nickel problem that was affecting the glutathione-s-transferase has significantly reduced. The only changes I've made to my routine that I consider may be significant are starting Lipoceutical Glutathione and FIR saunas soon after the first test. Sue Adrienne G. wrote: > Sheila, Thanks! with those enzyme names I was able to track it down. > So, where do I get those two things tested? (Was it expensive?) > But even more, what recommendations were you given to correct those > problems. When feasible I like to experiment with the solution rather > than spend money for tests. This list is intended for patients to share personal experiences with each other, not to give medical advice. If you are interested in any treatment discussed here, please consult your doctor. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2006 Report Share Posted October 14, 2006 Hi Adrienne and Louella It's called Lipoceutical Glutathione and I take a small teaspoon-full most days. This is it: www.gshnow.com I'm brighter and have slightly more energy. My CFS doc says it takes time for the body to heal so she expects improvements to come over a period of (unspecified) time. This year I've also managed to bring SODase into normal range so I should be seeing some benefits some time soon. Sue Adrienne G. wrote: > , I forgot;can you feel any difference? louella wrote: > wot kind of lipoceutical glut do u use? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2006 Report Share Posted October 14, 2006 Hi Sue, Did you have to work up to the daily dose of EG? Did you have any adverse reactions, such as flu-like symptoms? About the SOD...what is the test for that, and what did you do to raise it? Have you addressed catalase, another enzyme contributing to mitochondia function? Thanks! Katrina > > wot kind of lipoceutical glut do u use? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2006 Report Share Posted October 15, 2006 Sheila, Thank you! Astonishing how much cheaper your tests seem. I am indeed in USA. Thank you for the thoroughness of your response. I will study it- and go back on selenium. I don't recall that using it made a noticeable difference, but maybe I didn't use it long enough. Will talk to my doc about it. For some time I was eating brazil nuts regularly, but then my assistant quit and could not prepare them. Due to tooth problems I was eating them as part of home made pesto, (instead of pinon nuts.) And I made it with cilantro instead of basil, so with the garlic it was a very healthy concoction. I suppose I could even try it with coconut oil instead of the olive oil. The Italians would not recognise it, but so what. Adrienne Re: Rich and all, re: RBC glut Hi Adrienne, Well I am in the UK, but perhaps you are in the US? Over here the tests were done at Biolab in London. The glutathione peroxidase test costs about £19 $13) and I think the glutathione transferase test was approx £28($19) or you can get it as part of the toxic screen test which is a fancy sensitive liver test costing about £58($39). If you are in the US perhaps someone can chime in here with the info on labs aand these tests. If you have low glutathione peroxidase, my doc said it can be due to 3 things, 1. low glutathione - well you've not got that 2. selenium deficiency 3. genetic variants of the enzyme that don't work so well - Rich said that some of these variants work more efficiently with increased selenium intake though. Selenium can be toxic in large doses. I am on 800mcg, this is a high dose, prescribed by the doc, for 2 months to see how the levels of the enzyme increase, or not. Then the dose will be reviewed. I don't think I'd want to carry on at this dose longterm without the docs OK. I think the recommended max dose is normally about 400mcg. I had been on 200mcg for years but still seem to have been low. If you read this article http://tinyurl.com/g7dbg you will see that methylselenomethionine seems to be thought of as the best form and the easiest for your body to detoxify. Jarrow (activated selenium), Solaray, Ecological Formulas and Vitamin Research Products seem to make selenium supplements in that form that form. Brazil nuts are also a very good soource of selenium and brazil nut oil. Sorry I don't know what the treatment would be if you had glutathione-s-transferase problems. Do you have lyme? I case it might be relevent, Rich wrote a post on his theory of how lyme disease becomes chronic. I can't find the original but you can read it at message number 106236. If you read it you will see how it fits in with glutathione peroxidase and selenium. BW, Sheila > > > > I hate to bother anyone,( especially you, Rich), but I am kind of in > a stuck place, now that my test results have come back and my > glutathione level is apparently ok. > > I remember Rich saying there was the possibility that even if GSH is > replete there might be a blockage preventing its use. > > I have tried to research the archive (on my desktop) for this post, > but I am incapable of doing that. > > What sort of block could that be and what would be the work-around? > > Thanks, in advance. > > Adrienne > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2006 Report Share Posted October 15, 2006 Hi Katrina I had no adverse reaction to the glutathione and started at one teaspoon. Interesting point though, I hadn't thought about it. The SODase test was done by Biolab but the solution to the problem was to take copper (1mg) at breakfast, manganese (5mg) at lunch and zinc (30mg) before bed. Simple and effective. I haven't looked at catalase. BW Sue kattemayo wrote: > Did you have to work up to the daily dose of EG? Did you have any > adverse reactions, such as flu-like symptoms? > > About the SOD...what is the test for that, and what did you do to raise it? > > Have you addressed catalase, another enzyme contributing to mitochondia > function? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2006 Report Share Posted October 15, 2006 Hi Adrienne, Sorry I converted the £/$ the wrong way round! So the tests over here aren't as cheap ! eg glutathione $36 glutathuione peroxidase $53 toxic screen test $108 Sorry about that, my brain is " programmed " for changing dollars into pounds for buying supplements from the US, not the other way round! BW, Sheila > > > > > > I hate to bother anyone,( especially you, Rich), but I am kind of in > > a stuck place, now that my test results have come back and my > > glutathione level is apparently ok. > > > I remember Rich saying there was the possibility that even if GSH is > > replete there might be a blockage preventing its use. > > > I have tried to research the archive (on my desktop) for this post, > > but I am incapable of doing that. > > > What sort of block could that be and what would be the work-around? > > > Thanks, in advance. > > > Adrienne > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2006 Report Share Posted October 15, 2006 No problem! Still sounds extremely cheap to me! RBC glutathione was I think, $75 last month. Adrienne Re: Rich and all, re: RBC glut Hi Adrienne, Sorry I converted the £/$ the wrong way round! So the tests over here aren't as cheap ! eg glutathione $36 glutathuione peroxidase $53 toxic screen test $108 Sorry about that, my brain is " programmed " for changing dollars into pounds for buying supplements from the US, not the other way round! BW, Sheila > > > > > > I hate to bother anyone,( especially you, Rich), but I am kind of in > > a stuck place, now that my test results have come back and my > > glutathione level is apparently ok. > > > I remember Rich saying there was the possibility that even if GSH is > > replete there might be a blockage preventing its use. > > > I have tried to research the archive (on my desktop) for this post, > > but I am incapable of doing that. > > > What sort of block could that be and what would be the work-around? > > > Thanks, in advance. > > > Adrienne > > > > > > Quote Link to comment Share on other sites More sharing options...
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