Deths talk at recent DAN! conference

[Guest guest]

I know Jill and Rich have studied Deth's work and I wonder if you can

help me out. I've watched his presentation at the April DAN! Conference

and have a couple of questions:

a. he talks about how the methionine synthase (MS) enzyme shuts down

during oxidative stress and he says it can occur 2 ways

1. temporarily when cobalamin is oxidized

2. clipping SAMe when the oxidative stress is more permanent.

He talks about nature doing this. What does he mean ? Does he mean

nature is shutting down the enzyme when it sees cobalamin is oxidized ?

b. in a slide he shows the activity of the MS enzyme in the liver,

cortical and other parts of the brain. In the liver, the

hydroxycobalamin shows the higher activity, in the brain it is the MB12

that shows the higher activity. He then goes on to say that this means

the brain has the form of the enzyme w/o the SAMe domain. How does he

conclude this ?

Regards,