help with Yasko test results, just arrived!

[Guest guest]

My test results from Yasko's lab are in. Anyone who can help explain

what this means and what to do about it, please chime in. Surprise, no

CBS upregualation reported, however, I am unclear about the rest: ACE

Del16 +/+ deletion, COMT H62H ± hetero, MAO A R297R+/- hetero, MTHFR

E429A (A1298C) +/+ C, MTRR H595Y ± hetero, MTRR A919G (A66G) ± hetero,

SUOX S370S +/+ C, AHCY-01 hetero, MTRR-04 hetero, MTRR-06 V652V hetero,

Genovations: CYP1A1 MspI T-C and I462V and CYP1B1 V432L and N453S, (1)

SNP in COMT V158M, (NULL) GSTM1 1p13.3, (1) SNP in GSTP1 l104V, (1) SNP

in SOD2 A16V.

Highlights of Doctor's Data baseline prior to Yasko protocol (test

completed 8/9, sent on 8/18):

Elevated Ammonia 55700 (12000-49000)

Elevated Urea 560 (150-590)

Anserine 210 (<95)

Cysteine 52 (25-73), Cystathionine 31 (8-30), 1-methylhistidine 280

(70-280), somewhat elevated

Elevated 3-methylhistidine 2770 (55-1100) and Glycine 1810 (500-4100)

somewhat elevated

Elevated Phosphoscripe 130 (25-100)

Glutamine/glutemate 18 (5-180),

GABA 3.1 (<15) 35 percentile

Neurological markers are low across the board, Gordon put me on

Alinia for a gut paracite when he review this.

Do I need BH4? Do I have to worry about step 1 glutamate/Gaba ratios?

[Guest guest]

Hi Joanne,

I’ve been studying the autismforum.com and if I remember correctly,

Yasko says 3 things cause low BH4:

a. MTHFRA1298C which you have

b. Aluminum toxicity

c. CBS upregulation

Rich says you can tell if you are low in BH4 if your

phenylalainine/tyrosine ratio is high.

Yasko also has a list of indications from tests that indicate low BH4:

High hippuric

Increased 8 hydroxy 2 deoxy guanosine

(lack of SAMe or high ammonia can also cause increased 8

hydroxy 2 deoxy guanosine)

Elevated phenylalanine, phenyl lactate, phenyl acetate,

phenylethylamine

Increased ammonia

help with Yasko test results, just arrived!

My test results from Yasko's lab are in. Anyone who can help explain

what this means and what to do about it, please chime in. Surprise, no

CBS upregualation reported, however, I am unclear about the rest: ACE

Del16 +/+ deletion, COMT H62H ± hetero, MAO A R297R+/- hetero, MTHFR

E429A (A1298C) +/+ C, MTRR H595Y ± hetero, MTRR A919G (A66G) ± hetero,

SUOX S370S +/+ C, AHCY-01 hetero, MTRR-04 hetero, MTRR-06 V652V hetero,

Genovations: CYP1A1 MspI T-C and I462V and CYP1B1 V432L and N453S, (1)

SNP in COMT V158M, (NULL) GSTM1 1p13.3, (1) SNP in GSTP1 l104V, (1) SNP

in SOD2 A16V.

Highlights of Doctor's Data baseline prior to Yasko protocol (test

completed 8/9, sent on 8/18):

Elevated Ammonia 55700 (12000-49000)

Elevated Urea 560 (150-590)

Anserine 210 (<95)

Cysteine 52 (25-73), Cystathionine 31 (8-30), 1-methylhistidine 280

(70-280), somewhat elevated

Elevated 3-methylhistidine 2770 (55-1100) and Glycine 1810 (500-4100)

somewhat elevated

Elevated Phosphoscripe 130 (25-100)

Glutamine/glutemate 18 (5-180),

GABA 3.1 (<15) 35 percentile

Neurological markers are low across the board, Gordon put me on

Alinia for a gut paracite when he review this.

Do I need BH4? Do I have to worry about step 1 glutamate/Gaba ratios?

[Guest guest]

Joanee,

Just rechecking....You are not showing a + in the CBS 699T or the CBS A360A/??

Janet

<maryellen1909@...> wrote:

Hi Joanne,

I’ve been studying the autismforum.com and if I remember correctly,

Yasko says 3 things cause low BH4:

a. MTHFRA1298C which you have

b. Aluminum toxicity

c. CBS upregulation

Rich says you can tell if you are low in BH4 if your

phenylalainine/tyrosine ratio is high.

Yasko also has a list of indications from tests that indicate low BH4:

High hippuric

Increased 8 hydroxy 2 deoxy guanosine

(lack of SAMe or high ammonia can also cause increased 8

hydroxy 2 deoxy guanosine)

Elevated phenylalanine, phenyl lactate, phenyl acetate,

phenylethylamine

Increased ammonia

help with Yasko test results, just arrived!

My test results from Yasko's lab are in. Anyone who can help explain

what this means and what to do about it, please chime in. Surprise, no

CBS upregualation reported, however, I am unclear about the rest: ACE

Del16 +/+ deletion, COMT H62H ± hetero, MAO A R297R+/- hetero, MTHFR

E429A (A1298C) +/+ C, MTRR H595Y ± hetero, MTRR A919G (A66G) ± hetero,

SUOX S370S +/+ C, AHCY-01 hetero, MTRR-04 hetero, MTRR-06 V652V hetero,

Genovations: CYP1A1 MspI T-C and I462V and CYP1B1 V432L and N453S, (1)

SNP in COMT V158M, (NULL) GSTM1 1p13.3, (1) SNP in GSTP1 l104V, (1) SNP

in SOD2 A16V.

Highlights of Doctor's Data baseline prior to Yasko protocol (test

completed 8/9, sent on 8/18):

Elevated Ammonia 55700 (12000-49000)

Elevated Urea 560 (150-590)

Anserine 210 (<95)

Cysteine 52 (25-73), Cystathionine 31 (8-30), 1-methylhistidine 280

(70-280), somewhat elevated

Elevated 3-methylhistidine 2770 (55-1100) and Glycine 1810 (500-4100)

somewhat elevated

Elevated Phosphoscripe 130 (25-100)

Glutamine/glutemate 18 (5-180),

GABA 3.1 (<15) 35 percentile

Neurological markers are low across the board, Gordon put me on

Alinia for a gut paracite when he review this.

Do I need BH4? Do I have to worry about step 1 glutamate/Gaba ratios?