Re: Yaskyo-salt- genes Kurt thoughts

[Guest guest]

Kurt, I have a feeling that in the past, before vaccines, and a

polluted world, and moms with amalgams, and cows or soys milk formula

(which does not have mom's immunogloblins and antibodies for passive

immunization while a baby is developing) the cases of autism that did

occur were not unlike many that occur today. They were probably not

pediatric CFS per se, those kids probably had mutations and had an

unfortunate combination of insults, such as getting a few retroviruses

in a single year, or mom having a particular flu or retrovirus while

pregnant to which she was vulnerable in terms of upregulation of

cytokines/poor methylation/inadequate glutathione, and to which her

embryo, having inherited her genes, or a double whammy if unfortunate

from Dad and Mom, was also very vulnerable while developing...I don't

think the model is so much time and place sensitive as offering us

understanding of the basic mechanisms.

One part i have yet to look at is why estrogen protects girls from

autism, while many of adult cfs'ers ie women, find that estrogen makes

cfids or lyme symptoms worse/flare.

Many questions to ask.

I agree the genetics allows us hope.

Since recently a fellow awoke from a 19 year coma, lets be otpimistic

about the adults, too. It might just take more time...

You did a great job of using mental/emotional reprogramming to get

your sleep,and it has impressed me. I do not think I could do so well!

I'll probably just suffer through the benzo withdrawal, which I

haven't started yet because i have to figure out/calculate the

titration part, i.e. how much water to put in and then remove.

[Guest guest]

Hi, Jill.

My current hypothesis for the higher prevalence of CFS in women, and

the exacerbation of CFS symptoms by estrogens, is as follows:

In order for the estrogens to be able to rise and fall as they do in

women, there must be control of the production of estrogens, and

there must also be means to detox estrogens so that they can be

removed from the body.

Considering estradiol, which is the most potent estrogen, there are

several pathways for detox, and they are in competition. One of the

enzymes that processes estradiol is CYP1B1. So far, in the eight

PWCs (8 women, 2 men) for whom I have Detoxigenomic profile results,

all have a SNP in CYP1B1. This is an upregulation, and means that

this enzyme will compete more successfully for estradiol than normal

in these people. This enzyme converts estradiol to 4-catechol

estradiol. Normally, this is methylated by COMT, but 5 out of the 6

women with CFS are heterozygous for a downregulation SNP of COMT.

If catechol estradiol is not methylated, it can auto-oxidize to form

semiquinones and quinones. These are normally conjugated by

glutathione, but 5 out of 6 of these women also have downregulating

SNPs in their glutathione transferase enzymes. This means that all

eight of these women will convert more of their estradiol to 4-

catechol estradiol than normal. The conversion of this to

semiquinones and quinones involves the production of oxidizing free

radicals. If the semiquinones and quinones are not conjugated, they

can oscillate back and forth between each other, and that produces

oxidizing free radicals, also. So these women will have more

production of oxidizing free radicals than normal.

The upshot of all this is that it appears that women are more

vulnerable to developing CFS than men are, even if both have these

SNPs, because they use these enzymes to process estradiol, which men

have a lot less of. When estradiol cannot be properly processed, the

resulting substances produce a load of oxidizing free radicals that

men do not have, and this load biases these women more toward

glutathione depletion and oxidative stress. It's like another straw

on the camel's back (I don't mean to compare women to camels!)

Concerning the greater prevalence of autism in boys, Jon Pangborn

reviewed the hypotheses for that in his book. One of them involves

testosterone potentiation of mercury toxicity, but there are several

others as well. I don't think anybody knows for sure which one or

ones are actually important.

Rich

> One part i have yet to look at is why estrogen protects girls from

> autism, while many of adult cfs'ers ie women, find that estrogen

makes

> cfids or lyme symptoms worse/flare.

[Guest guest]

Sorry, I meant 6 women, not 8.

Rich

>

> > One part i have yet to look at is why estrogen protects girls

from

> > autism, while many of adult cfs'ers ie women, find that estrogen

> makes

> > cfids or lyme symptoms worse/flare.

>

[Guest guest]

Rich, does Yasko's test look at this CYP1B1? As you know, I haven't

found a way to get Genova testing. I'd have to go get a special doctor

in NJ or CT just for that.

> >

> > > One part i have yet to look at is why estrogen protects girls

> from

> > > autism, while many of adult cfs'ers ie women, find that estrogen

> > makes

> > > cfids or lyme symptoms worse/flare.

> >

>

[Guest guest]

Jill,

No her panel does not.

Janet

jill1313 <jenbooks13@...> wrote:

Rich, does Yasko's test look at this CYP1B1? As you know, I haven't

found a way to get Genova testing. I'd have to go get a special doctor

in NJ or CT just for that.

> >

> > > One part i have yet to look at is why estrogen protects girls

> from

> > > autism, while many of adult cfs'ers ie women, find that estrogen

> > makes

> > > cfids or lyme symptoms worse/flare.

> >

>

[Guest guest]

Hi, Jill.

No, it doesn't, and that's one of the things I'm planning to discuss

with her in October. Sue T. has emphasized the importance of detox

SNPs in her case, as has C.J., as has Janet. They're important for

tolerance of the herbal treatments in Amy's program, as well as for

understanding what should be avoided and what toxins might have

built up in the body.

I know it's a problem for New Yorkers to get lots of the alternative

testing done. I've heard from New Yorkers who have gone to New

Jersey or even to Virginia. What about the direct testing outfits,

such as in Louisiana, who take your money, apply a doctor's

signature, and get you the test. Can you legally go through one of

them?

Rich

> > >

> > > > One part i have yet to look at is why estrogen protects

girls

> > from

> > > > autism, while many of adult cfs'ers ie women, find that

estrogen

> > > makes

> > > > cfids or lyme symptoms worse/flare.

> > >

> >

>

[Guest guest]

Rich, I don't know about those programs in Louisiana. What are they?

I'm planning to go in October too...just a quick train ride on Acela

Express from NY to Boston, which is a wonderful train, with a quiet

car and plugs for your laptop...

I highly suspect I'd have a problem with estrogen like that you

mentioned. There is estrogen dominance on my maternal side, and my

maternal grandmother and my mother had bad migraines during their

menstrual cycles. My grandmother apparently would have to hole up in a

dark room, she'd get so sick.

> > > >

> > > > > One part i have yet to look at is why estrogen protects

> girls

> > > from

> > > > > autism, while many of adult cfs'ers ie women, find that

> estrogen

> > > > makes

> > > > > cfids or lyme symptoms worse/flare.

> > > >

> > >

> >

>

[Guest guest]

Hi, Jill.

Check out this site:

http://www.directlabs.com/

Rich

>

> Rich, I don't know about those programs in Louisiana. What are

they?

>

> I'm planning to go in October too...just a quick train ride on

Acela

> Express from NY to Boston, which is a wonderful train, with a quiet

> car and plugs for your laptop...

>

> I highly suspect I'd have a problem with estrogen like that you

> mentioned. There is estrogen dominance on my maternal side, and my

> maternal grandmother and my mother had bad migraines during their

> menstrual cycles. My grandmother apparently would have to hole up

in a

> dark room, she'd get so sick.