To Mark London, was Re: I GOT MY GENETICS BACK FROM YASKO!!!

[Guest guest]

Hi, Mark.

Thanks for posting these. I always appreciate your insights. I

think your ideas about Recup and the citrate are very

interesting.

The action of the CBS enzyme polymorphisms is a subject I would like

to better understand. Owens, who runs the sulfurstories list,

says that humans and rats don't respond the same in this regard.

She bases it on what Rosemary Waring has found, but she hasn't cited

the references yet. So far, I think that what Amy Yasko is saying

about this is correct, based on reports from the few PWCs who have

tested positively for the CBS SNPs about their experiences with

ammonia and sulfur-containing substances.

If you haven't already done so, I think you would appreciate

watching the talks by Deth and Jill at the Washington,

D.C. DAN! conference. They both said some interesting things that

relate to this, I think. You can find the talks at

http://www.danwebcast.com. Signing up is free.

Rich

> According to the latest review article on CBS, the action of these

> polymorphisms enzyme activity is " not determined " yet. See:

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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>

> Basically, a study from 2000 found an association between lowered

> homocysteine and those polymorphisms, and thus theorized that those

> polymorphisms increased CBS enzyme activity. However, later

studies

> have not confirmed that lowered homocysteine levels are associated

> with those polymorphisms:

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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> t=AbstractPlus & list_uids=10833331 & query_hl=21 & itool=pubmed_docsum

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>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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> t=AbstractPlus & list_uids=12529702 & query_hl=18 & itool=pubmed_docsum

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>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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> t=AbstractPlus & list_uids=15866085 & query_hl=21 & itool=pubmed_docsum

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>

> The first study is interesting, because what they did find, was

that

> 2 of the polymorphisms influenced the lowering effects of folic

acid on

> homocysteine. Since the CBS and folic acid effects on

homocysteine are

> 2 different pathways, they theorized that the 2 pathways influence

> each other some way. I.e. could excess folic acid increase CBS

> activity in

> some of the polymorphisms? This is still total speculation,

though.

>

> Btw, one of these polymorphisms that was more sensitive to folic

> acid, was not one of the ones that was found in the 2000 study to

be

> associated with lowered homocysteine, i.e. 699C was sensitive to

> folic acid, while 699T was found in the 2000 study to be associated

> with lowered homocysteine. Go figure. In any event, none of these

> others studies showed any association with homocysteine levels and

> any of these polymorphisms.