RE: Response from Dr. Yasko / ACE - Salt question

August 8, 2006

Rich,

Thanks for this generous offer to act as a conduit.

I have a question. This is about the ACE SNP. Could this mutation be

involved in salt sensitivity? For example, if a person has this, what

will happen to their sodium regulation when they try the salt/c protocol

or Recup?

The reason I ask this is that there is an interesting divergence in

responses to salt/c. For some people there is an almost immediate and

profound improvement. This sometimes gradually leads to nearly full

recovery from CFS, Lyme, and their other pathologies. So I am wondering

whether the salt is actually acting as a genetic bypass for them, if

they have an ACE regulation issue where they do not regulate aldosterone

properly in the presence of certain triggers (such as Lyme perhaps), and

are continually dumping sodium.

Next, in a small number of cases there is a profound negative response

to salt/c, with symptoms that are overwhelming. In these cases a small

daily dose of salt (2-4g) seems to act on them like a 12-18g daily dose

in an average person. Could this indicate an ACE deletion issue where

they over-produce aldosterone given certain triggers (again maybe Lyme

or other mycotoxins), and thus actually have a type of sodium overload

from salt/c?

On the other hand, some people do not respond at all to salt/c. In some

cases they find that they react better to certain types of salt or C.

But in other cases there is no response ever, and usually they quit the

protocol. So maybe these people do not have the ACE mutation at all?

Or perhaps there is some other issue involved here.

Maybe these are unanswerable, but the thought occurred to me that if

salt is actually a genetic bypass for some PWC and PWL, this might

explain part of the effects of salt/c, and also perhaps Recup.

--Kurt

Response from Dr. Yasko

Hi, all.

I received a very nice email from Dr. Amy Yasko in response to mine.

She noted that she started out working on adult neurological

inflammation, and she assured me that she has the same level of

compassion for adults as she does for children.

She is willing to take questions from people in our group starting in

mid- to late-October, but is currently focused on preparing for two

days of lectures on Oct. 7 and 8 in Boston. She may need to prepare

as many as 1000 slides for these lectures, based on past experience.

So if people have general questions about her theoretical model,

testing or treatment, please feel free to post them, and I will begin

sending the ones I am not able to answer to her in October. Those who

are on her treatment program and have specific questions about their

cases can continue to submit them to the parents and adults section of

autismanswer.com, and her assistant, , is currently routing at

least one per day from that section to her. As you can imagine, Dr.

Yasko is pretty swamped with analyzing test results, a small amount of

private practice and answering a large volume of questions from the

autism parents.

Rich

August 8, 2006

Hi, Kurt.

I think you have a good hypothesis. In order to test it, I guess

you would have to have an ACE SNP test run on a few people who have

had these three responses to the salt/C treatment. You might be able

to get some clues by querying them about whether they suffer from

anxiety, whether they have some sodium or potassium measurements on

their blood serum, whether they have cortisol measurements, whether

they have difficulty coping with stress, whether they suffer from

hypoglycemia or low blood pressure, how they do on the flashlight

pupil test, etc., but ultimately, I think you would need ACE SNP

data to test this out.

Rich

>

> Rich,

> Thanks for this generous offer to act as a conduit.

>

> I have a question. This is about the ACE SNP. Could this

mutation be

> involved in salt sensitivity? For example, if a person has this,

what

> will happen to their sodium regulation when they try the salt/c

protocol

> or Recup?

>

> The reason I ask this is that there is an interesting divergence in

> responses to salt/c. For some people there is an almost immediate

and

> profound improvement. This sometimes gradually leads to nearly

full

> recovery from CFS, Lyme, and their other pathologies. So I am

wondering

> whether the salt is actually acting as a genetic bypass for them,

if

> they have an ACE regulation issue where they do not regulate

aldosterone

> properly in the presence of certain triggers (such as Lyme

perhaps), and

> are continually dumping sodium.

>

> Next, in a small number of cases there is a profound negative

response

> to salt/c, with symptoms that are overwhelming. In these cases a

small

> daily dose of salt (2-4g) seems to act on them like a 12-18g daily

dose

> in an average person. Could this indicate an ACE deletion issue

where

> they over-produce aldosterone given certain triggers (again maybe

Lyme

> or other mycotoxins), and thus actually have a type of sodium

overload

> from salt/c?

>

> On the other hand, some people do not respond at all to salt/c.

In some

> cases they find that they react better to certain types of salt or

C.

> But in other cases there is no response ever, and usually they

quit the

> protocol. So maybe these people do not have the ACE mutation at

all?

> Or perhaps there is some other issue involved here.

>

> Maybe these are unanswerable, but the thought occurred to me that

if

> salt is actually a genetic bypass for some PWC and PWL, this might

> explain part of the effects of salt/c, and also perhaps Recup.

>

> --Kurt

>

> Response from Dr. Yasko

>

> Hi, all.

>

> I received a very nice email from Dr. Amy Yasko in response to

mine.

> She noted that she started out working on adult neurological

> inflammation, and she assured me that she has the same level of

> compassion for adults as she does for children.

>

> She is willing to take questions from people in our group starting

in

> mid- to late-October, but is currently focused on preparing for

two

> days of lectures on Oct. 7 and 8 in Boston. She may need to

prepare

> as many as 1000 slides for these lectures, based on past

experience.

>

> So if people have general questions about her theoretical model,

> testing or treatment, please feel free to post them, and I will

begin

> sending the ones I am not able to answer to her in October. Those

who

> are on her treatment program and have specific questions about

their

> cases can continue to submit them to the parents and adults

section of

> autismanswer.com, and her assistant, , is currently routing at

> least one per day from that section to her. As you can imagine,

Dr.

> Yasko is pretty swamped with analyzing test results, a small

amount of

> private practice and answering a large volume of questions from

the

> autism parents.

>

> Rich

>

August 8, 2006

Dear Kurt,

Low potassium..so I am eating bananas, everyday, now.

Sodium affects my blood pressure, by raising it, however, I was checking it

while I was on Salt/C, and it did not raise too high, with my use of

Micardis, which has been my most effective anti-hypertensive.

Have Hypoglycemia...

Usually don't have as much anxiety, as I notice in other people..was a

psychotherapist...although, realistically, with the lack of effective treatment,

in CFS/ME, there is much to be anxious about...not very depressed, either...as

I know there is a better place..and I don't want to waste the time, being

depressed.

Have high blood pressure...high heart rate...not very good MDs..that is why

I tried Salt/C....but a good dentist..

My pupils have, always, been too dilated..in light.

Does that help, at all?

Rich...what is your opinion?

Amelia

August 8, 2006

On Aug 8, 2006, at 2:04 PM, rvankonynen wrote:

> Hi, Kurt.

>

> I think you have a good hypothesis. In order to test it, I guess

> you would have to have an ACE SNP test run on a few people who have

> had these three responses to the salt/C treatment. You might be able

> to get some clues by querying them about whether they suffer from

> anxiety, whether they have some sodium or potassium measurements on

> their blood serum, whether they have cortisol measurements, whether

> they have difficulty coping with stress, whether they suffer from

> hypoglycemia or low blood pressure, how they do on the flashlight

> pupil test, etc., but ultimately, I think you would need ACE SNP

> data to test this out.

Well, if ACE is on the Yasko panel, we'll get at least one data point

on this hypothesis when I get my report back in late September or so.

Sara

>

> Rich

>

>>

>> Rich,

>> Thanks for this generous offer to act as a conduit.

>>

>> I have a question. This is about the ACE SNP. Could this

> mutation be

>> involved in salt sensitivity? For example, if a person has this,

> what

>> will happen to their sodium regulation when they try the salt/c

> protocol

>> or Recup?

>>

>> The reason I ask this is that there is an interesting divergence in

>> responses to salt/c. For some people there is an almost immediate

> and

>> profound improvement. This sometimes gradually leads to nearly

> full

>> recovery from CFS, Lyme, and their other pathologies. So I am

> wondering

>> whether the salt is actually acting as a genetic bypass for them,

> if

>> they have an ACE regulation issue where they do not regulate

> aldosterone

>> properly in the presence of certain triggers (such as Lyme

> perhaps), and

>> are continually dumping sodium.

>>

>> Next, in a small number of cases there is a profound negative

> response

>> to salt/c, with symptoms that are overwhelming. In these cases a

> small

>> daily dose of salt (2-4g) seems to act on them like a 12-18g daily

> dose

>> in an average person. Could this indicate an ACE deletion issue

> where

>> they over-produce aldosterone given certain triggers (again maybe

> Lyme

>> or other mycotoxins), and thus actually have a type of sodium

> overload

>> from salt/c?

>>

>> On the other hand, some people do not respond at all to salt/c.

> In some

>> cases they find that they react better to certain types of salt or

> C.

>> But in other cases there is no response ever, and usually they

> quit the

>> protocol. So maybe these people do not have the ACE mutation at

> all?

>> Or perhaps there is some other issue involved here.

>>

>> Maybe these are unanswerable, but the thought occurred to me that

> if

>> salt is actually a genetic bypass for some PWC and PWL, this might

>> explain part of the effects of salt/c, and also perhaps Recup.

>>

>> --Kurt

>>

>> Response from Dr. Yasko

>>

>> Hi, all.

>>

>> I received a very nice email from Dr. Amy Yasko in response to

> mine.

>> She noted that she started out working on adult neurological

>> inflammation, and she assured me that she has the same level of

>> compassion for adults as she does for children.

>>

>> She is willing to take questions from people in our group starting

> in

>> mid- to late-October, but is currently focused on preparing for

> two

>> days of lectures on Oct. 7 and 8 in Boston. She may need to

> prepare

>> as many as 1000 slides for these lectures, based on past

> experience.

>>

>> So if people have general questions about her theoretical model,

>> testing or treatment, please feel free to post them, and I will

> begin

>> sending the ones I am not able to answer to her in October. Those

> who

>> are on her treatment program and have specific questions about

> their

>> cases can continue to submit them to the parents and adults

> section of

>> autismanswer.com, and her assistant, , is currently routing at

>> least one per day from that section to her. As you can imagine,

> Dr.

>> Yasko is pretty swamped with analyzing test results, a small

> amount of

>> private practice and answering a large volume of questions from

> the

>> autism parents.

>>

>> Rich

>>

August 8, 2006

Sara,

ACE is on the Yakso panel.

Janet

Mercuria <mercuria@...> wrote: