Folinic acid and reactivated Epstein-Barr virus in CFS

[Guest guest]

I had mistakingly posted some of my labs. Just curious if the following say

anything about whether folinic acid would help, and also if it says anything

about my methylation cycle.

I have the following blood test results:

1) B12 at the top of normal

2) Folic Acid above normal

3) Homocysteine below normal

4) Methylmalonic Acid below normal.

Jim

[Guest guest]

Hi, all.

Check this abstract. This is another instance of people homing in

on the right treatments, but coming from different directions and

explaining the effectiveness of the treatments in different ways. I

suspect that they were actually compensating for a block in the

folate metabolism. The supplemental folinic acid probably enabled

the production of RNA and DNA for the proliferation of new

lymphocytes, and that helped the cell-mediated immunity to go after

the EBV. Note that the people subjectively felt better, but were

not cured. I suspect the reason is that the blocks in the folate

metabolism (and methylation cycle) were not completely compensated

for using folinic acid alone, though it was certainly helpful. I

think this supports the DAN! and Yasko approaches.

Rich

" Clinical activity of folinic acid in patients with chronic fatigue

syndrome.

Journal: Arzneimittelforschung. 2006;56(6):399-404.

Lundell K, Qazi S, Eddy L, Uckun FM.

Institute and Clinics, St. , MN

55113, USA.

NLM Citation: PMID: 16889122

A high incidence of severe B-cell immunodeficiency and chronic

reactivated Epstein-Barr virus (EBV) infection in patients with

chronic fatigue syndrome (CFS) is reported herein.

Of the 58 patients evaluated, 100% had evidence of prior EBV

exposure and 72% had evidence for reactivated EBV infection.

Notably, 94% of CFS patients had B-cell immunodeficiency with a

marked depletion of their CD19+IgM+ mature B-lymphocyte population.

A remarkable 81% of CFS patients experienced subjective improvement

of their symptoms after treatment with folinic acid (CAS 58-05-9,

leucovorin).

The findings provide unprecedented evidence that CFS frequently is a

folinic acid responsive clinical entity accompanied by B-cell

immunodeficiency and inappropriate antibody responses to EBV. "

Rich

[Guest guest]

Thats really interesting and good news as well, but what about viral

reactivation? Did they check to see if indices of viral reactivation were

reduced?

rvankonynen <richvank@...> wrote: Hi, all.

Check this abstract. This is another instance of people homing in

on the right treatments, but coming from different directions and

explaining the effectiveness of the treatments in different ways. I

suspect that they were actually compensating for a block in the

folate metabolism. The supplemental folinic acid probably enabled

the production of RNA and DNA for the proliferation of new

lymphocytes, and that helped the cell-mediated immunity to go after

the EBV. Note that the people subjectively felt better, but were

not cured. I suspect the reason is that the blocks in the folate

metabolism (and methylation cycle) were not completely compensated

for using folinic acid alone, though it was certainly helpful. I

think this supports the DAN! and Yasko approaches.

Rich

" Clinical activity of folinic acid in patients with chronic fatigue

syndrome.

Journal: Arzneimittelforschung. 2006;56(6):399-404.

Lundell K, Qazi S, Eddy L, Uckun FM.

Institute and Clinics, St. , MN

55113, USA.

NLM Citation: PMID: 16889122

A high incidence of severe B-cell immunodeficiency and chronic

reactivated Epstein-Barr virus (EBV) infection in patients with

chronic fatigue syndrome (CFS) is reported herein.

Of the 58 patients evaluated, 100% had evidence of prior EBV

exposure and 72% had evidence for reactivated EBV infection.

Notably, 94% of CFS patients had B-cell immunodeficiency with a

marked depletion of their CD19+IgM+ mature B-lymphocyte population.

A remarkable 81% of CFS patients experienced subjective improvement

of their symptoms after treatment with folinic acid (CAS 58-05-9,

leucovorin).

The findings provide unprecedented evidence that CFS frequently is a

folinic acid responsive clinical entity accompanied by B-cell

immunodeficiency and inappropriate antibody responses to EBV. "

Rich

---------------------------------

Stay in the know. Pulse on the new .com. Check it out.

[Guest guest]

Hi, Cort.

I haven't seen the full paper yet, but I suspect that if they had

measured serum antibody titers, they would have said so in the

abstract, so I doubt it.

Rich

Hi, all.

>

> Check this abstract. This is another instance of people homing in

> on the right treatments, but coming from different directions and

> explaining the effectiveness of the treatments in different ways.

I

> suspect that they were actually compensating for a block in the

> folate metabolism. The supplemental folinic acid probably enabled

> the production of RNA and DNA for the proliferation of new

> lymphocytes, and that helped the cell-mediated immunity to go

after

> the EBV. Note that the people subjectively felt better, but were

> not cured. I suspect the reason is that the blocks in the folate

> metabolism (and methylation cycle) were not completely compensated

> for using folinic acid alone, though it was certainly helpful. I

> think this supports the DAN! and Yasko approaches.

>

> Rich

>

>

> " Clinical activity of folinic acid in patients with chronic

fatigue

> syndrome.

>

> Journal: Arzneimittelforschung. 2006;56(6):399-404.

>

> Lundell K, Qazi S, Eddy L, Uckun FM.

>

> Institute and Clinics, St. , MN

> 55113, USA.

>

> NLM Citation: PMID: 16889122

>

> A high incidence of severe B-cell immunodeficiency and chronic

> reactivated Epstein-Barr virus (EBV) infection in patients with

> chronic fatigue syndrome (CFS) is reported herein.

>

> Of the 58 patients evaluated, 100% had evidence of prior EBV

> exposure and 72% had evidence for reactivated EBV infection.

> Notably, 94% of CFS patients had B-cell immunodeficiency with a

> marked depletion of their CD19+IgM+ mature B-lymphocyte

population.

>

> A remarkable 81% of CFS patients experienced subjective

improvement

> of their symptoms after treatment with folinic acid (CAS 58-05-9,

> leucovorin).

>

> The findings provide unprecedented evidence that CFS frequently is

a

> folinic acid responsive clinical entity accompanied by B-cell

> immunodeficiency and inappropriate antibody responses to EBV. "

>

>

> Rich

>

>

>

>

>

>

>

> ---------------------------------

> Stay in the know. Pulse on the new .com. Check it out.

>

>

[Guest guest]

Dear Rich,

Thank you very much for posting this. Another piece of the puzzle for me I

think.

I was found to be low in folate (blood test) and have been taking prescription

strength folic acid

(5mg) each day. It has made a difference but not a cure for me, by any means.

I have a MTHFR mutation so added folinic acid recently after reading all the

recent stuff.

It's not made any difference but maybe I need to take it in large quantities

like the ordinary

folic acid?

Hopefully I'll be able to find this entire aticle sometime and read what

quantities they were

given.

Thanks for all your hard work!!

Kindest regards,

Annette

___________________________________________________________

Try the all-new . " The New Version is radically easier to use " – The

Wall Street Journal

http://uk.docs./nowyoucan.html

[Guest guest]

Hi, Annette.

Yes, I believe the dosing for folinic acid is the same as for folic

acid, based on Pangborn. I hope the folinic acid helps you.

Rich

>

> Dear Rich,

>

> Thank you very much for posting this. Another piece of the puzzle

for me I think.

>

> I was found to be low in folate (blood test) and have been taking

prescription strength folic acid

> (5mg) each day. It has made a difference but not a cure for me, by

any means.

>

> I have a MTHFR mutation so added folinic acid recently after

reading all the recent stuff.

>

> It's not made any difference but maybe I need to take it in large

quantities like the ordinary

> folic acid?

>

> Hopefully I'll be able to find this entire aticle sometime and

read what quantities they were

> given.

>

> Thanks for all your hard work!!

>

> Kindest regards,

> Annette

>

>

>

> ___________________________________________________________

> Try the all-new . " The New Version is radically easier

to use " – The Wall Street Journal

> http://uk.docs./nowyoucan.html

>