Why CFS'ers have High Cholesterol ?

[Guest guest]

Hi

Any ideas why people with CFS may have high cholesterol levels?

Is it because bile isnt being converted via cholesterol and hence it builds

up ?

Regards

CS

[Guest guest]

CS

Not all cfs people have high cholesterol ,i have very low cholesterol and so do

other cfs

sufferes i know .

Please get thing in balance .

D.

>

> Hi

>

> Any ideas why people with CFS may have high cholesterol levels?

>

> Is it because bile isnt being converted via cholesterol and hence it builds

> up ?

>

>

> Regards

> CS

>

>

>

[Guest guest]

The 'ciguatera epitope' found in at least one study has been

described as a 'cholesterol-like' compound made in the liver - I have

been trying to find out if it is included in the cholesterol count

and if so as what (LDL, HDL, other). This has puzzled me, too.

[Guest guest]

It's common for PWC to have high cholesterol. But a few have

extremely low cholesterol. And they are usually opposites in

body/metabolic type. I haven't seen too many with normal

cholesterol.

I've read all kinds of reasoning. The cholesterol is a protection

mechanism that binds with toxins produced by bacteria. There are

also studies suggesting HDL cholesterol is actually an

antiinflamamtory. (Inflammation is also caused by bacerial toxins).

I'm sure there are more, but that's all I can think of at the moment.

penny

>

> Hi

>

> Any ideas why people with CFS may have high cholesterol levels?

>

> Is it because bile isnt being converted via cholesterol and hence

it builds

> up ?

>

>

> Regards

> CS

>

>

>

[Guest guest]

Cholesterol is part of the coagulation process and thus depending on

which acquired or inherited coagulation defect is involved with the

CFIDSers, it could become high...

" Dr. Mandal is investigating the role of cholesterol in blood

coagulation. " http://www.uthct.edu/Media/NR2005/nr123005a.htm

" There are at least two possible explanations for the aspirin-

resistance phenomenon, " said Professor Szczeklik. " One is high levels

of blood cholesterol, which can in itself promote coagulation events in

the blood stream. In patients with high cholesterol levels, aspirin in

in normal doses has hardly any anti-clotting effects, whereas treatment

with a statin (inhibitor of cholesterol) significantly reduces blood

clotting. In patients with coronary heart disease, aspirin exerts it

anti-coagulant effects only when blood cholesterol is in the 'normal'

range. "

http://www.thedoctorslounge.net/hematology/articles/aspirin_failure/inde

x.htm

>

> Hi

>

> Any ideas why people with CFS may have high cholesterol levels?

>

> Is it because bile isnt being converted via cholesterol and hence it

builds

> up ?

>

>

> Regards

> CS

>

>

>

[Guest guest]

This is a very interesting question. Here is a little info from the

Columbia dictionary on how cholesterol is used, then a few thoughts.

" Cholesterol: fatty lipid lipids, a broad class of organic products

found in living systems. Most are insoluble in water but soluble in

nonpolar solvents. Cholesterol can be found in large concentrations in

the brain, spinal cord, and liver. The liver is the most important site

of cholesterol biosynthesis, although other sites include the adrenal

glands and reproductive organs. By means of several enzymatic reactions,

cholesterol is synthesized from

<http://columbia.thefreedictionary.com/acetic+acid> acetic acid;

it then serves as the major precursor for the synthesis of vitamin D3,

of the various steroid hormones, including cortisol, and aldosterone in

the adrenal gland, and of the sex hormones progesterone, estrogen, and

testosterone. Cholesterol is excreted from the liver in the form of a

secretion known as bile; it sometimes crystallizes in the gall bladder,

to form gallstones.

My thoughts - Maybe high cholesterol in PWC is due to its low

utilization by the adrenal gland and other HPA systems.

Another hypothesis, this could be due to dysbiosis. This is because

cholesterol is formed from acetic acid, which is a by-product of the

fermentation process. Maybe if we have over-fermentation we have

higher production of cholesterol

Another possibility is a liver regulation problem, given that more

cholesterol is produced in the liver than elsewhere. And we already

know that we have major liver regulation issues.

And yet another possibility is an over-active adrenal gland, as that

gland both uses and produces cholesterol.

Or maybe just part of the genetic profile.

My personal guess is that it is a combination of the above factors,

particularly the combination of poor liver regulation, overactive

adrenals, and dysbiosis.

--Kurt

Why CFS'ers have High Cholesterol ?

Hi

Any ideas why people with CFS may have high cholesterol levels?

Is it because bile isnt being converted via cholesterol and hence it

builds

up ?

Regards

CS

[Guest guest]

Hi, CS.

In the liver and the intestine, primarily, cholesterol is

synthesized from acetyl-CoA. Acetyl-CoA in turn is synthesized from

beta oxidation of fatty acids and from pyruvate, which comes from

glycolysis of carbohydrates. In the mitochondria of the cells,

acetyl-CoA is also normally fed into the beginning of the citric

acid cycle for extracting energy to generate ATP.

Many PWCs are depleted in glutathione. This puts a partial blockade

into the citric acid cycle at aconitase, near the beginning of the

cycle. As a result, citric acid, which is upstream of the partial

blockade, is often found to build up in PWCs, and I would expect

that acetyl-CoA would, also, since it precedes citric acid in the

cycle, though it has not been measured, as far as I know. It may be

that a buildup of acetyl-CoA favors a higher rate of production of

cholesterol in these PWCs.

Many PWCs also have high triglycerides in their blood, and I suspect

that this occurs also because of the citric acid cycle partial

blockade, resulting from glutathione depletion, because the blockade

hinders the burning of fatty acids in the citric acid cycle.

These are just hypotheses, though, not proven. It would be

interesting to know if there is a correlation between glutathione

depletion and elevated cholesterol and triglycerides in PWCs.

Rich

>

> Hi

>

> Any ideas why people with CFS may have high cholesterol levels?

>

> Is it because bile isnt being converted via cholesterol and hence

it builds

> up ?

>

>

> Regards

> CS

>

>

>

[Guest guest]

Dear Rich,

What if you have HIGH TRYGLERIDES (was 425, but reduced carbo intake,

now 225), BUT LOW CHOLESTEROL (but always had low cholestrol, now

174), LOW HDL (around the 20s), LDL (not really high, but I don't

have the figures, now)-..I have Insulin Resistance, and I thought the

Triglycerides were high, because of that disease process..

TIA,

Amelia

, " rvankonynen " <richvank@...> wrote:

>

> Hi, CS.

>

> In the liver and the intestine, primarily, cholesterol is

> synthesized from acetyl-CoA. Acetyl-CoA in turn is synthesized

from

> beta oxidation of fatty acids and from pyruvate, which comes from

> glycolysis of carbohydrates. In the mitochondria of the cells,

> acetyl-CoA is also normally fed into the beginning of the citric

> acid cycle for extracting energy to generate ATP.

>

> Many PWCs are depleted in glutathione. This puts a partial

blockade

> into the citric acid cycle at aconitase, near the beginning of the

> cycle. As a result, citric acid, which is upstream of the partial

> blockade, is often found to build up in PWCs, and I would expect

> that acetyl-CoA would, also, since it precedes citric acid in the

> cycle, though it has not been measured, as far as I know. It may

be

> that a buildup of acetyl-CoA favors a higher rate of production of

> cholesterol in these PWCs.

>

> Many PWCs also have high triglycerides in their blood, and I

suspect

> that this occurs also because of the citric acid cycle partial

> blockade, resulting from glutathione depletion, because the

blockade

> hinders the burning of fatty acids in the citric acid cycle.

>

> These are just hypotheses, though, not proven. It would be

> interesting to know if there is a correlation between glutathione

> depletion and elevated cholesterol and triglycerides in PWCs.

>

> Rich

>

>

> >

> > Hi

> >

> > Any ideas why people with CFS may have high cholesterol levels?

> >

> > Is it because bile isnt being converted via cholesterol and hence

> it builds

> > up ?

> >

> >

> > Regards

> > CS

> >

> >

> >

[Guest guest]

Dear Blake,

Where did you read that Mycoplasma LOWERS TOTAL Cholesterol? as I have LOW

total cholesterol (171), but the HDL is way too low..and the LDL if probably

too high..

TIA,

Amelia

[Guest guest]

Hi Penny,all,

My Cholesterol has been in normal range the entire 21 years I have been ill

w/ME/CFIDS. It went somewhat above this year.

A couple of points...again, I see the importance of distinguishing which CFS we

are talking about (especially with absolute statements)...if we do not, with the

current state of this list, we may as well be the Tower of Babel, IMO.

{Not to mention, overlapping conditions, early/later stage, etc.}

Do you remember where you got this high/low CFS-specific info?

Due to memory, brain and technology, I am not the greatest at specific links and

citations myself. And we should be able to pass on info even when we can't

reference perfectly.

Sometimes I put " earliest CFS research " , or the year. Or CFIDS

Specialists/studies. OR ME/CFS. Because *then*, most being done was on ME type,

" original "

CFS...as opposed to the ever widening category of

people/conditions/research/treatment now under the term " CFS " .

About Cholesterol, it has very important functions...maybe about collagen? And

crucial needs.

This is written about regarding drugs to lower it, which could be into a

dangerous zone.

See, no references...but thought it was worth mentioning, following up on...more

complex than we might think.

thanks for the other info,

Katrina

> >

> > Hi

> >

> > Any ideas why people with CFS may have high cholesterol levels?

> >

> > Is it because bile isnt being converted via cholesterol and hence

> it builds

> > up ?

> >

> >

> > Regards

> > CS

> >

> >

> >

[Guest guest]

I have read that mycoplasma lowers total cholesterol. Hypothyroid rasises

cholesterol. Gaining body fat also rasises cholesterol. All three of these

facvtors are present in large subgroups of those with CFS.

Blake

[Guest guest]

Hi Amelia,

I think it was in the papers of the Australian CFS research group -

Butt//McGregor. Cant remember exactly which paper.

Blake

Re: Re: Why CFS'ers have High Cholesterol ?

Dear Blake,

Where did you read that Mycoplasma LOWERS TOTAL Cholesterol? as I have LOW

total cholesterol (171), but the HDL is way too low..and the LDL if probably

too high..

TIA,

Amelia