Re: Coagulation defect and IgGA deficiency

[Guest guest]

Hi Diane

Sorry to read that you have low levels of IgA, IgM and IgG. Do you

know if they have been low always, or if it is a result of a disease

process?

Regarding the problem of blood transfusion when people have IgA

deficiency I found this information in the Merck Manual Online

Medical Library:

" If given blood transfusions or immune globulin that contains IgA,

some people with selective IgA deficiency produce antibodies against

IgA. Such people may have a severe allergic (anaphylactic) reaction

(see Allergic Reactions: Anaphylactic Reactions) the next time they

are given a blood transfusion or immune globulin. They should wear a

medical identification bracelet or tag to alert doctors to take

precautions against such reactions " .

http://www.merck.com/mmhe/sec16/ch184/ch184c.html

My daughter, who is 23 years old, and has had ME/CFS since 2001, has

low level of serum IgA (last test showed 0,5 g/l, normal range here

is 0,7 - 4,3 g/l). She does not have this bracelet, I think I should

look into this.

ne

>

>At my recent Dr. visit she said my coapgulation defect didn't

require heparin, lumbrokinase is doing the job. She also is

concerned for the IgGA deficiency that has shown up in my lab work,

along with lowered levels of IgGM and IgGG. I am unable to locate

information that would help me understand what those low levels

mean. She told me I should wear a medical alert bracelet,and never

have a blood transfusion related to the IgGA deficiency. It also

excludes me from any immune system modulation therapy. Can anyone

enlighten me further on this?

> Diane in MI

[Guest guest]

ne

Thank you so much for the information. I have no idea if I've had this always

or if it's just come with all the rest of what's going on with FM/CFIDS etc. 4

years ago after a wasp sting I first experienced the flu like aching that has

become my life. It has become an every day experience, some days worse than

others. I have obstructive sleep apnea, now on CPAP. Hypothyroidism and

coagulation defect to round out the picture. What kind of disease process would

cause IgGA deficiency? I'll have to do a deeper search as I've not been able to

turn up anything so far.

Thanks for your explanation and info.

Diane in MI

Re: Coagulation defect and IgGA deficiency

Hi Diane

Sorry to read that you have low levels of IgA, IgM and IgG. Do you

know if they have been low always, or if it is a result of a disease

process?

Regarding the problem of blood transfusion when people have IgA

deficiency I found this information in the Merck Manual Online

Medical Library:

" If given blood transfusions or immune globulin that contains IgA,

some people with selective IgA deficiency produce antibodies against

IgA. Such people may have a severe allergic (anaphylactic) reaction

(see Allergic Reactions: Anaphylactic Reactions) the next time they

are given a blood transfusion or immune globulin. They should wear a

medical identification bracelet or tag to alert doctors to take

precautions against such reactions " .

http://www.merck.com/mmhe/sec16/ch184/ch184c.html

My daughter, who is 23 years old, and has had ME/CFS since 2001, has

low level of serum IgA (last test showed 0,5 g/l, normal range here

is 0,7 - 4,3 g/l). She does not have this bracelet, I think I should

look into this.

ne

.

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[Guest guest]

Hi Diane

I have read that IgA deficiency sometimes is acquired, not

inherited, but when trying to find out how it is acquired I didn`t

find much information so far. I found this example where a child

acquired IgA deficiency after infections, but there were some

inherited immune dysregulations involved in the case:

" Acquired IgA deficiency "

http://tinyurl.com/octzm

I have read about a other cases where IgA deficiency occurred

because of medication with a certain type of anti-convulsants (for

instance Phenytoin).

While reading, I realized that my daughter has low IgA, but not IgA

deficiency, as it seems that IgA deficiency means a serum IgA level

less than 0.05 g/l. My daughter had 0,5 g/l in the last test, normal

range here is 0,7 - 4,3 g/l.

I read that some bacteria and also candida albicans have proteases

that can degrade IgA1 (which as far as I understood is the

dominating part of serum IgA). For instance they write about

bacteria destroying structure and function of IgA1 here:

" IgA1 protease "

http://tinyurl.com/ma99n

Maybe this degradation can lead to low IgA, but maybe not to IgA

deficiency, and maybe that is what happens in my daughter`s case.

But your case seems to be different, with IgA deficiency and also

low IgM and IgG. May I ask if that leads to many infections, and did

your doctor give any treatment suggestions?

ne

> I have no idea if I've had this always or if it's just come with >

> all the rest of what's going on with FM/CFIDS etc. What kind of >

>disease process would cause IgGA deficiency?

>Diane in MI

>

> ----- Original Message -----

> From: s_fibaek

Hi Diane

>

Sorry to read that you have low levels of IgA, IgM and IgG. Do you

know if they have been low always, or if it is a result of a disease

process?

>

[Guest guest]

Prior to the past 3 years I've been relatively healthy, you know the supermom

that has to take care of everyone else. I began having migrating aching in

muscles, first one place then another, intermittently, then more often. This

past winter came to a screeching halt as all I did was sleep in my heated

recliner, then get up and go to bed. OSA was finally identified, treated with

CPAP. Last winter I had a bout with the flu, and residual sinusitis that set up

camp. In April, to make CPAP work effectively, I was put on Allegra and

Flonase, for the sinusitis. I don't remember having frequent illnesses even in

the past 3 years. But any illness is more often than what I used to have.

The Dr. mentioned that immune modulators would have been a treatment plan EXCEPT

they are contraindicated in the IgA deficiency. Now I have to think about

whether she called it just " low IgA " or deficiency. The lab report says, my

level IgA is 59 Norm 81 - 463 mg/DL

Thanks for your input

Diane in MI

Re: Coagulation defect and IgGA deficiency

Hi Diane

I have read that IgA deficiency sometimes is acquired, not

inherited, but when trying to find out how it is acquired I didn`t

find much information so far. I found this example where a child

acquired IgA deficiency after infections, but there were some

inherited immune dysregulations involved in the case:

" Acquired IgA deficiency "

http://tinyurl.com/octzm

I have read about a other cases where IgA deficiency occurred

because of medication with a certain type of anti-convulsants (for

instance Phenytoin).

While reading, I realized that my daughter has low IgA, but not IgA

deficiency, as it seems that IgA deficiency means a serum IgA level

less than 0.05 g/l. My daughter had 0,5 g/l in the last test, normal

range here is 0,7 - 4,3 g/l.

I read that some bacteria and also candida albicans have proteases

that can degrade IgA1 (which as far as I understood is the

dominating part of serum IgA). For instance they write about

bacteria destroying structure and function of IgA1 here:

" IgA1 protease "

http://tinyurl.com/ma99n

Maybe this degradation can lead to low IgA, but maybe not to IgA

deficiency, and maybe that is what happens in my daughter`s case.

But your case seems to be different, with IgA deficiency and also

low IgM and IgG. May I ask if that leads to many infections, and did

your doctor give any treatment suggestions?

ne

> I have no idea if I've had this always or if it's just come with >

> all the rest of what's going on with FM/CFIDS etc. What kind of >

>disease process would cause IgGA deficiency?

>Diane in MI

>

> ----- Original Message -----

> From: s_fibaek

Hi Diane

>

Sorry to read that you have low levels of IgA, IgM and IgG. Do you

know if they have been low always, or if it is a result of a disease

process?

>

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