[NVIC] Molecular Mimicry Inducing Hep B Vaccine MS

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E-NEWS FROM THE NATIONAL VACCINE INFORMATION CENTER

Vienna, Virginia http://www.nvic.org

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UNITED WAY/COMBINED FEDERAL CAMPAIGN

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" Protecting the health and informed consent rights of children since 1982. "

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BL Fisher Note:

Bonnie Dunbar, Ph.D., former Professor of Molecular and Cell Biology at

Baylor and now conducting vaccine and infectious disease research in Kenya,

spoke at the NVIC's Second International Public Conference on Vaccination in

2000 on autoimmune mechanisms for hepatitis B vaccine-induced injury,

including molecular mimicry. Dr. Dunbar was honored in 1994 by NIH as the

First Margaret Pittman Lecturer for her pioneering work as a vaccine

researcher. In the late 1990's, Dr. Dunbar became an outspoken critic of the

lack of government agency and industry research into the biological

mechanisms of hepatitis B vaccine reactions. She applied for and was turned

down by NIH for grants to investigate genetic and other high risk factors

for hepatitis B vaccine induced brain and immune system dysfunction. Her

brother, a distinguished PhD, was left with multiple injuries from a

reaction to a hepatitis B vaccination.

Medical Hypotheses. 2005 May 19; [Epub ahead of print]

Multiple sclerosis and hepatitis B vaccination: Could minute contamination

of the vaccine by partial Hepatitis B virus polymerase play a role through

molecular mimicry?

Faure E.

E.R. Biodiversity and Environment, case 5, University of Provence, Place

Victor Hugo, 13331 Marseilles cedex 3, France.

Reports of multiple sclerosis developing after hepatitis B vaccination have

led to the concern that this vaccine might be a cause of multiple sclerosis

in previously healthy subjects. Some articles evidenced that minor Hepatitis

B virus (HBV) polymerase proteins could be produced by alternative

transcriptional or translational strategies. Their detection is very

difficult because they are in minute concentration and probably

enzymatically inactive, however, it was shown that they could be exposed on

the outside of the virus particles and also be immunogenic. In addition, HBV

polymerase shares significant amino acid similarities with the human myelin

basic protein. We hypothesise that some of the apparent adverse reactions to

the vaccine could be due to a process called of molecular mimicry, the HBV

polymerase, which could be a contaminant in the recombinant or

plasma-derived vaccines, could act as autoantigens and induce autoimmune

demyelinating diseases such as multiple sclerosis.

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