Autism, An Extreme Challenge to Integrative Medicine

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http://www.chiro.org/research/ABSTRACTS/Autism.shtml

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http://www.thorne.com/pdf/journal/7-4/autism.pdf

Autism, An Extreme Challenge to Integrative Medicine. Part 1: The Knowledge

Base

This section is maintained by M. Painter, D.C.

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FROM: Altern Med Rev 2002 (Aug); 7 (4): 292–316 ~ FULL TEXT

http://www.thorne.com/pdf/journal/7-4/autism.pdf

Kidd PM

Parris Kidd, PhD (Cell Biology, University of California at Berkeley) -

Contributing Editor, Alternative Medicine Review; Health educator and

biomedical consultant to the supplement industry. Correspondence address:

847 Elm Street, El Cerrito, CA 94530

Autism, archetype of the autistic spectrum disorders (ASD), is a

neurodevelopmental disorder characterized by socially aloof behavior and

impairment of language and social interaction. Its prevalence has surged in

recent years. Advanced functional brain imaging has confirmed pervasive

neurologic involvement. Parent involvement in autism management has

accelerated understanding and treatment. Often accompanied by epilepsy,

cognitive deficits, or other neurologic impairment, autism manifests in the

first three years of life and persists into adulthood. Its etiopathology is

poorly defined but likely multifactorial with heritability playing a major

role. Prenatal toxic exposures (teratogens) are consistent with autism

spectrum symptomatology. Frequent vaccinations with live virus and toxic

mercurial content (thimerosal) are a plausible etiologic factor. Autistic

children frequently have abnormalities of sulfoxidation and sulfation that

compromise liver detoxification, which may contribute to the high body

burden of xenobiotics frequently found. Frequent copper-zinc imbalance

implies metallothionein impairment that could compound the negative impact

of sulfur metabolism impairments on detoxification and on intestinal lining

integrity. Intestinal hyperpermeability manifests in autistic children as

dysbiosis, food intolerances, and exorphin (opioid) intoxication, most

frequently from casein and gluten. Immune system abnormalities encompass

derangement of antibody production, skewing of T cell subsets, aberrant

cytokine profiles, and other impairments consistent with chronic

inflammation and autoimmunity. Coagulation abnormalities have been

reported. Part 2 of this review will attempt to consolidate progress in

integrative management of autism, aimed at improving independence and

lifespan for people with the disorder.

Autism, An Extreme Challenge to Integrative Medicine. Part 2: Medical

Management

This section is maintained by M. Painter, D.C.

Send all comments or additions to: p@...

http://www.thorne.com/altmedrev/.fulltext/7/6/472.pdf

FROM: Altern Med Rev 2002 (Dec); 7 (6): 472–499 ~ FULL TEXT

Kidd PM

Parris Kidd, PhD (Cell Biology, University of California at Berkeley) -

Contributing Editor, Alternative Medicine Review; Health educator and

biomedical consultant to the supplement industry. Correspondence address:

847 Elm Street, El Cerrito, CA 94530

Autism and allied autistic spectrum disorders (ASD) present myriad

behavioral, clinical, and biochemical abnormalities. Parental

participation, advanced testing protocols, and eclectic treatment

strategies have driven progress toward cure. Behavioral modification and

structured education are beneficial but insufficient. Dietary restrictions,

including removal of milk and other casein dairy products, wheat and other

gluten sources, sugar, chocolate, preservatives, and food coloring are

beneficial and prerequisite to benefit from other interventions.

Individualized IgG or IgE testing can identify other troublesome foods but

not non-immune mediated food sensitivities. Gastrointestinal improvement

rests on controlling Candida and other parasites, and using probiotic

bacteria and nutrients to correct dysbiosis and decrease gut permeability.

Detoxification of mercury and other heavy metals by DMSA/DMPS chelation can

have marked benefit. Documented sulfoxidation-sulfation inadequacies call

for sulfur-sulfhydryl repletion and other liver p450 support. Many nutrient

supplements are beneficial and well tolerated, including dimethylglycine

(DMG) and a combination of pyridoxine (vitamin B6) and magnesium, both of

which benefit roughly half of ASD cases. Vitamins A, B3, C, and folic acid;

the minerals calcium and zinc; cod liver oil; and digestive enzymes, all

offer benefit. Secretin, a triggering factor for digestion, is presently

under investigation. Immune therapies (pentoxifyllin, intravenous

immunoglobulin, transfer factor, and colostrum) benefit selected cases.

Long-chain omega-3 fatty acids offer great promise. Current pharmaceuticals

fail to benefit the primary symptoms and can have marked adverse effects.

Individualized, in-depth clinical and laboratory assessments and

integrative parent-physician-scientist cooperation are the keys to

successful ASD management.

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Sheri Nakken, R.N., MA, Classical Homeopath

http://www.nccn.net/~wwithin/vaccine.htm