Presumptive Evidence for an Infectious Disease Process

[Guest guest]

Dear April,

The petition requesting CDC action to specifically test

autistic children for stealth-adapted viruses was successfully completed. Thank

you for your help. I recently sent a manuscript to CDC " Journal of Emerging

Infectious Diseases. " It is entitled " Complex Multi-system Illnesses Occurring

Within a Family: Presumptive Evidence for an Infectious Disease Process, " and is

copied below. In response to be article not being accepted for publication, I am

trying to gather more examples of " Family Illnesses of Presumptive Infectious

Origin. " This survey has been added to the web site www.s3support.com I would

appreciate your drawing attention to this endeavor by forwarding this e-mail to

others and encouraging your readers to do the same. Kind regards,

Complex Multi-system Illnesses Occurring Within a Family:

Presumptive Evidence for an Infectious Disease Process.

W. , M.D., Ph.D.

Center for Complex Infectious Diseases

Rosemead CA 91770

Author address: 3328 s Avenue, Rosemead CA 91770

Telephone number: (626) 616-2868

Fax number (626) 799-1700

e-mail: s3support@...

Word count: Abstract 83. Text 2,010

Running Title: Presumptive Infectious Cause of Illnesses in a Family

Key words:

Stealth viruses

Epidemic

ACE pigments

Delusional parasitosis

Prurigo nodularis

Amytrophic lateral sclerosis, ALS

Attention deficit hyperactivity disorder, ADHD

Abstract:

Society is witnessing an increasing incidence of illnesses with

neuropsychiatric manifestations. Prominent examples include autism and learning

disorders in children, depression and chronic fatigue syndrome in adults and

neurodegenerative diseases in the elderly. Although clinically diverse, all of

these illnesses could be contributed to by infectious agents. If so, one might

expect to trace the occurrence and progression of various brain damaging

illnesses among various family members. An example of this occurring in three

generations of a family is presented in this paper.

Article Summary Line:

The progressive occurrence of chronic complex disease conditions among members

of a family is consistent with an underlying infectious illness that is not

being addressed by either medical practitioners or the Public Health Service.

Family History

A Caucasian family enjoyed upper middle class living in the United

States. The wife had a walking impairment, similar to that of her father. It had

been diagnosed as a mild case of Charcot-Marie-Tooth disease and had not caused

any major disability outside of restricting sports activities. Her father was

head of data processing for a bank and lived happily with his wife of 30 years,

enjoying strong community and social support. His life changed dramatically

when, four years ago, at 65 years of age he experienced a discrete but rather

non-specific flu-like illness with fatigue and muscle aching. Rather than

resolving, the daughter recalls a gradual but progressive deterioration in his

demeanor and personality. He began to express anger, complain of impaired memory

and slept excessively during the day. He would sit idly with a blank stare. The

illness forced his retirement. Severe headaches soon began and hydrocephalus

developed requiring placement of a shunt. His voice became mono-tonal and his

muscles began to atrophy with notable rigidity. Clinical diagnoses have included

Alzheimer's disease for which he was prescribed donepezil hydrochloride

(Aricept), and Parkinson's-like illness. At least 3 outbreaks of shingles-like

eruptions have occurred over the last 4 years. Persisting small ulcerating skin

lesions and recurrent mouth ulcerations have also been noted.

The man's wife was forced to deal with family matters. Within several months,

however, this task became more difficult. She too began to complain of tingling

and weakness in her arms, tinnitus, shortness of breath with occasional panic

attacks, and irregular bouts of diarrhea. She had worked as a school teacher

with excellent social and communicative skills. These functions changed

dramatically as she progressively became more distant with paranoia. She was

diagnosed as being hypothyroid and hypertensive, for which medications was

prescribed. Radiologically identified lesions in her lung were considered

granulomatous without any definitive diagnosis. Thrombocytopenia was also noted.

The woman became obese and neglectful of her own and her husband's care.

Because of the deterioration of her parents' health, her daughter

arranged for them to move into her home. The move occurred approximately a year

after the onset of her father's illness. Plans were made for renovating the

house to accommodate her parents. Not long thereafter both the daughter and her

husband became ill and the renovations have remained unfinished. The daughter

recalls feelings of excessive fatigue, irregular bouts of diarrhea, dull

persisting headaches and insomnia. Small ulcerating, acne-like pruritic skin

lesions were noted from which she could extract pigmented, irregularly shaped

structures. Draining lymph nodes were slightly enlarged and painful. Her hair

became more brittle and her face acquired a drained look with dark circles

beneath her eyes. A biopsy of a skin lesion was classified as prurigo nodularis

(1-2) from neurotic excoriation. Her description of the structures from the

lesions was interpreted as delusional parasitosis, also called Ekbom's disease

(3-4).

The wife's husband, who is also now aged 38, was a successful marketing manager

for a major telephone company. Within several months of his in-laws moving into

the house, he experienced an episode of diarrhea with occasional vomiting

accompanied by bouts of coughing. As these symptoms resolved, he experienced

overwhelming fatigue, insomnia, headaches and unprovoked perspiration. His

personality changed dramatically from that of a caring husband and father to an

indifferent, neglectful and occasionally angry individual. His wife noted

significant dementia aggravated by dysarthria. Neurological examination revealed

wasting of small muscles of his hands and generalized hyper-reflexia and

increased muscle tone. He exhibited bilateral extensor plantar responses, a

positive Hoffmann 's sign and mild fasciculations. He was diagnosed as having

amyotrophic lateral sclerosis and prescribed Riluzole. He was also placed on

Baclofen and Celexa for depression, Accupril for hypertension and Prevacid for

indigestion. His wife has noted a peculiar body odor and acne-like lesions. He

now walks with difficulty and is unable to rotate door handles. Both shoulders

are frozen from lack of movement. His wife's major concern is the apparent

indifference he shows to his own care, or to the deteriorating health of their

four children.

His eldest son is now 20 and has noted a marked loss of short term memory and

diminishing muscle strength with frequent tingling. A daughter of 14 had a

distinct mono-like illness with sore throat and fatigue that has not fully

resolved. Her school and sporting performance changed from being a gifted

student active on the softball team to barely being able to cope with her

studies and relegated to a back-up cheerleading squad. Her mother withdrew her

from school to try to provide home schooling to make up for the shortcomings in

her learning capacity. The daughter is on Prozac for depression. She experiences

frequent migraines and has become somewhat obese. Daughters now 11 and 5 years

are also experiencing short term memory loss and are unable to attend regular

school because of an attention deficit disorder. The 11 yea r old developed a

severe thrombocytopenia, with platelet levels as low as 10,000/ml. Platelets

have been maintained between 50-100,000/ml with repeated gamma globulin

injections. A 1 cm cyst was identified in the pineal gland and is being managed

conservatively. The child has slight eosinophilia. The children's hair has been

thinning with a defined bald spot on the child with thrombocytopenia. All three

children regularly develop small ulcerating mouth lesions that persist for 1-2

weeks. They express little joy in life, have lost most of their friends and

obtain little or no emotional support from their father.

The children's mother has also had to deal with recent onset illnesses among

her siblings, several of whom have tried to help with the care of their parents.

A now 30 year old brother moved in with the parents in their own home soon after

his father became ill. From being a successful artist he has become socially

withdrawn, depressed with outbursts of anger and suicidal thoughts. He has been

unable to hold a steady job and now works as a part time bar tender. A sister,

now 36, has developed a lupus-like illness with a positive ANA, recurrent

miscarriages, aching joints and muscles, shortness of breadth, chronic fatigue,

depression and marked weight gain. Her husband has sinusitis and what have

called fungal skin lesions. Another brother, now aged 44, and his wife, have had

two outbreaks of shingles in the last year. Fou r years ago, their two children

stayed with the grandparents. A baby girl at the time and now aged 4 has been

diagnosed as having chronic granulomatous disease, which is extremely rare in

girls. The diagnosis was offered to explain skin lesions infected with

Chromobacterium violaceum.

A pet dog belonging to the grandparents was euthanized because of protruding

skin lesions, unsteady gait and uncontrolled in-house urination. A dog belonging

to the daughter became unusually skittish and aggressive shortly after the

parents moved in the house and was also euthanized.

Discussion

The above description underscores several of the problems in our

current medical system. First, none of the attending physicians has bothered to

focus beyond an individual family member. Second, the labeling of the

grandfather's illness as idiopathic hydrocephalus and her husband's illness as

ALS has seemingly obviated the need to delve further into possible causes.

Third, in spite of the daughter's pleas, no one has lent credence to the

possibility of an infectious process progressively taking its toll on her

husband, herself and now her children. She has repeatedly been put down as being

neurotic, with delusional parasitosis. Her task is made all the harder by the

" la belle indifference " shown by her husband and by not wanting to emotionally

burden her children.

The woman made contact with the Center for Complex Infectious

Diseases because of published findings on stealth-adapted viruses. These viruses

are not effectively recognized by the cellular immune system and, therefore, do

not provoke an inflammatory response typical of most infectious diseases (5-13).

They can be detected by culturing with fibroblasts causing the normal spindle

shaped cells to form clusters of foamy vacuolated cells with syncytia (5,13).

The clusters commonly acquire pigmented inclusions, similar to complex

structures seen in tissue biopsies of stealth virus infected patients (12-13).

These mineral containing, electron donating materials accumulate in the tissue

culture supernatants of stealth virus cultures and seemingly provide the

striking repair process that o ccurs in infrequently re-fed stealth virus

cultures. Cell survival in spite of marked mitochondria disruption, as well as

various energy-based studies, supports the concept that these pigmented

materials provide an alternative (non-mitochondria) source of cellular energy

(12-13). They have accordingly been termed alternative cellular energy pigments

(ACE pigments).

Several stealth virus infected patients and animals have been noted to excrete

ACE-pigment-like materials in perspiration. As in the stealth virus cultures,

conglomerates of fine materials can form visible structures that can assume

irregular ribbon and thread shapes and can display varying colors. Patients have

reported seeing such structures on bed sheets and in bath water. They can also

be seen and felt attached to hair strands and sometimes misidentified as lice.

Patients are sometimes led to believe they are parasites because of the tendency

to show marked electrostatic attraction and repulsion. The particles are

typically auto-fluorescent and contain various minerals when examined using

energy dispersive X-ray (EDX) analysis. They have electron donating and electron

accepting properties. A patient support group has encouraged the use of the term

Morgellon ski n disease to refer to similar unusual skin lesions

(http://morgellons.org). Belated apologies are probably due to many patients

accused of being delusional because of sensing and observing ACE-pigment-like

particles within their skin.

Electrostatically active, auto-fluorescent fine particles can occasionally be

observed in patients' blood samples. Similar structures were likely

misidentified by earlier investigators, such as Antoine Bechamp, Virginia

Livingston and Gaston Naessens, as pleomorphic microorganisms, especially when

seen in association with ribbon and thread-like materials. ACE-pigment-like

threads can also be collected from environmental sources adding to the confusion

of their origins and underlying nature.

The performance of diagnostic stealth virus cultures was prohibited by the

Federal Government in late 2002 on questionable grounds (a copy of

correspondence relating to the inspection process is available at

www.s3support.com). Efforts to develop clinical assays for ACE-pigments and for

stealth virus infected bacteria were also stymied by Federal Regulations. These

actions have delayed progress in addressing an important Public Health issue.

The Nation is facing a growing incidence of chronic illnesses with

characteristic neuro-psychiatric symptoms. Among these illnesses, are nearly

20,000 cases of encephalitis diagnosed annually within United States hospitals

(14). Even when subjected to detailed diagnostic procedures, no etiological

cause can be identified in over 60% of patients with encephalitis (15). Autism

rates are increasing nationwide and childhood learning and behavioral problems

are overwhelming the educational facilities. The concept of stealth-adaptation

is not particularly difficult to grasp, and the published data, including findi

ngs in animals inoculated with these viruses are compelling (16). The conclusive

finding that several of these viruses were derived from African green monkey

simian cytomegalovirus (SCMV) has implicated their origin from live polio

vaccines (17-18). These vaccines were grown on kidney cells from SCMV

contaminated monkeys and virus DNA was present in licensed polio vaccines

(19-20). The argument that FDA investigators are unable to culture virus from

contaminated vaccines is unconvincing especially given the argument that they

cannot release any of the vaccines for independent testing because of

proprietary restrictions. FDA has also argued in legal proceedings against a

mother wishing to have the polio vaccine tested that her child had received

prior to developing a severe and eventually fatal neurological illness. Efforts

to test for stealth-adapted viruses in illnesses such as autism and learning

disorders in children, psychiatric illnesses in adults, and neurodegenerative

diseases in the elderly has been steadfastly avoided by Public Health officials.

Arguably, members of the family described in this paper, as well as other

individuals with brain damaging illnesses, etc, ought to bring legal suits to

compel Public Health testing for infectious agents. Such action may help protect

other members of society and will surely lead to the development of more

targeted therapy, including the use of natural products with ACE-pigment-like

activity.

References

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2. Accioly-Filho LW, Nogueira A, Ramos-e-Silva M. Prurigo nodularis of Hyde:

an update. J Eur Acad Dermatol Venereol. 14:75-82, 2000.

3. Wykoff RF. Delusions of parasitosis: a review. Rev Infect Dis.

9:433-7,1987.

4. Ait-Ameur A, Bern P, Firoloni MP, Menecier P. Delusional parasitosis or

Ekbom's syndrome. Rev Med Interne. 21:182-6, 2000.

5. WJ, Zeng LC, Ahmed K, Roy M. Cytomegalovirus-related sequences in an

atypical cytopathic virus repeatedly isolated from a patient with the chronic

fatigue syndrome. Am. J. Path. 145: 441-452, 1994.

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25:223-224,1995.

7. WJ. Simian cytomegalovirus-related stealth virus isolated from the

cerebrospinal fluid of a patient with bipolar psychosis and acute

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energy. Exp. Mol. Path. 74: 210-223, 2003.

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15. Glaser CA, Gilliam S, Schnurr D, Forghani B, Honarmand S, Khetsuriani N,

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16. WJ, Glass RT. Acute encephalopathy induced in cats with a stealth

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17. WJ, Ahmed KN, Zeng LC, Olsen J-C, Seward JG, Seehrai JS. African

green monkey origin of the atypical cytopathic 'stealth virus' isolated from a

patient with chronic fatigue syndrome. Clin. Diag. Virol. 4: 93-103, 1995.

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cytomegalovirus. Exp Mol Path. 66:3-7, 1999.

19. Sierra-Honigmann AM, Krause PR. Live oral poliovirus vaccines and simian

cytomegalovirus. Biologicals. 30:167-74, 2002.

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DEFINITION * TREATMENT * PREVENTION

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Autoimmunity Project) is a non-profit charity dedicated to obtaining funding for

independent research into the cause, treatment and prevention of autism and

other autoimmune disorders. Please visit our new website at

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