1979;Studies on untoward reactions to diphtheria and tetanus toxoids.MUST READ

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Dev Biol Stand. 1979;43:33-7. Related Articles, Links

Studies on untoward reactions to diphtheria and tetanus toxoids.

Relyveld EH, Henocq E, Bizzini B.

Adverse reactions to diphtheria and tetanus toxoids have frequently been

reported. The cause of these reactions has been attributed to different factors,

including sensitization by prior vaccination. However, this explanation does not

hold for primary vaccination. In this case, undesirable reactions to diphtheria

toxoid are most likely due to bacterial cellular fractions present in the

vaccines. In fact, we were able to demonstrate that fortuitous contact with

atoxigenic diphtheria strains can induce sensitization. Consequently,

vaccination should be carried out with highly purified toxoids, so as to prevent

untoward reactions due to the presence of impurities. It is also preferable to

detoxify purified toxins, rather than to purify crude toxoids.

PMID: 160349 [PubMed - indexed for MEDLINE]

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