can mumps vax induce remission in RRP

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http://www.rrpf.org/rrpf/therapies/PashleyMumps.htm

Can Mumps Vaccine Induce Remission in Recurrent Respiratory Papilloma?

By

Nigel R.T. Pashley, MB, BS, FRCS©

Presbyterian/St. Lukes Hospital, Denver, Colorado

Presented at the ASPO Annual Meeting, May 10, 2001

sdale, Arizona

 

Abstract

Study Objective: To describe our experience using laser excision and locally

injected mumps vaccine to induce remission in patients with recurrent

respiratory papilloma (RRP).

Design: Pilot study group of 11 children, subsequent case series of 18

children and 20 adults.

Setting: Tertiary care regional medical center.

Participants: Initially, 11 children with RRP all treated with laser excision

at regular intervals for at least a year without any adjuvant therapy. Later

18 children and 20 adults with RRP, some of whom had used various adjuvant

therapy with interval laser excision.

Interventions: Both patient groups continued their same interval laser exc

ision, using the same of similar laser, same clinical setting, same surgeon.

Locally injected mumps vaccine was then administered into the excision site

after

each laser removal of papilloma.

Outcome measures: Larynx and trachea were observed micro-photographically

with each treatment. Two consecutive disease free intervals and a follow up of

at

least one year were required criteria for remission.

Results: In the pilot study, remission was induced in 9/11 patients (81.8%)

by 1 to 10 injections, with follow up of 5 to 19 years. In the subsequent

series, remission was induced in 29/38 patients (76.3%) by 4 to 26 injections

and

follow up was 2 to 5 years.

Conclusions: Combined with serial laser excision, mumps vaccine positively

influences induction of remission in children with RRP. The mechanisms of this

effect are unclear but the treatment is readily available, cheap, and has a low

risk of side effects.

Nigel Pashley, MB, BS, FRCS©, FAAP

1601 East 19th Avenue, Suite 5500

Denver, Colorado 80218

Telephone (303) 830-7954

FAX: (303)830-7930

Email: npashley@...