Therapeutic vaccines against infectious diseases

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Therapeutic vaccines against infectious diseases

Philippe Moingeon, Almond and Michel de Wilde

Therapeutic vaccines against chronic infectious diseases aim at eliciting

broad humoral and cellular immune responses against multiple target antigens.

Importantly, the development of such vaccines will help to establish

surrogate...

Current Opinion in Microbiology, 2003, 6:5:462-471

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> Abstract

> Therapeutic vaccines against chronic infectious diseases aim at eliciting

> broad humoral and cellular immune responses against multiple target antigens.

> Importantly, the development of such vaccines will help to establish surrogate

> markers of protection in humans and thus will augment the subsequent

> development of efficient prophylactic vaccines. A combination of synthetic

> small-molecule drugs and immunotherapeutics is likely to represent a powerful

means of

> controlling chronic infections in the future. Challenges faced in developing

> therapeutic vaccines include the following: first, overcoming the potential

> impairment of immune responses due to established infection; second,

> optimizing schedules of vaccine administration in combination with standard of

care

> chemotherapy; and third, defining what biological and immunological read-outs

> should be used to infer vaccine efficacy.

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