Re: Neurotropin in CFS- case report

April 7, 2006

Fascinating. Thank you for posting this. One doesn't read of someone

being cured of CFS very often.

" Neurotropin(®), a non-protein extract from the inflamed skin of

rabbits inoculated with vaccinia virus, has been clinically used as an

analgesic drug for treatment of chronic pain. " -

http://lib.bioinfo.pl/search?field=PubMed & query=neurotropin

" Vaccinia virus is a big mystery in virology. It is not known whether

vaccinia virus is the product of genetic recombination, or if it is a

species derived from cowpox virus or variola virus by prolonged serial

passage, or if it is the living representative of a now extinct virus.

Vaccinia virus was used for smallpox vaccination via inoculation into

the superficial layers of the skin of the upper arm. However, with the

eradication of smallpox, routine vaccination with vaccinia virus has

ceased. Recent interest in vaccinia has focused on its possible usage

as a vector for immunization against other viruses. " -

http://www.stanford.edu/group/virus/pox/2000/vaccinia_virus.html

OK, here's a wild shot in the dark. Could the neurotropin be carrying

some form of immune activator (via vaccinia virus) which helps us kill

of the CFS inducing virus in us?

Kat.

April 7, 2006

It would appear that Neurotropin has an anti-viral effect:

Suppression by neurotropin of production of human immuno-deficiency

virus by the virus-producing MOLT-4 cell line.

Jpn J Cancer Res. 1987 Jul;78(7):648-50. Unique Identifier : AIDSLINE

MED/87307636

Imai H; Ikuta K; Ueda S; Suehiro S; Yamamoto N; Kato S

Abstract: The effect of neurotropin on human immuno-deficiency virus

(HIV) production in a virus-producing MOLT-4 (MOLT-4/HTLV-III) cell

line was studied. Culture of the cells for 4 days in the presence of

100 micrograms/ml of neurotropin resulted in a 72% decrease in the

number of infectious virus particles released into the culture fluid.

A pulse-labeling experiment to analyze the synthesis of HIV proteins

suggested that neurotropin may affect the budding process of the virus.

http://www.aegis.com/aidsline/1987/dec/M87C0124.html

Kat.

April 7, 2006

Hmmmm. I'm going to take an even bigger shot in the dark now. Could

it be that the rise in CFS is related to the removal of smallpox

vaccination in the general public? Could it somehow be related to the

vaccinia virus?

Smallpox vaccination stopped in 1972. CFS started appearing in

increased numbers in the mid-80's.

(Yes, I know I am wildly speculating, but that is how some theories

are formed).

Kat.

>

> Fascinating. Thank you for posting this. One doesn't read of someone

> being cured of CFS very often.

>

> " Neurotropin(®), a non-protein extract from the inflamed skin of

> rabbits inoculated with vaccinia virus, has been clinically used as an

> analgesic drug for treatment of chronic pain. " -

> http://lib.bioinfo.pl/search?field=PubMed & query=neurotropin

>

> " Vaccinia virus is a big mystery in virology. It is not known whether

> vaccinia virus is the product of genetic recombination, or if it is a

> species derived from cowpox virus or variola virus by prolonged serial

> passage, or if it is the living representative of a now extinct virus.

> Vaccinia virus was used for smallpox vaccination via inoculation into

> the superficial layers of the skin of the upper arm. However, with the

> eradication of smallpox, routine vaccination with vaccinia virus has

> ceased. Recent interest in vaccinia has focused on its possible usage

> as a vector for immunization against other viruses. " -

> http://www.stanford.edu/group/virus/pox/2000/vaccinia_virus.html

>

> OK, here's a wild shot in the dark. Could the neurotropin be carrying

> some form of immune activator (via vaccinia virus) which helps us kill

> of the CFS inducing virus in us?

>

> Kat.

>

April 7, 2006

Potential effect of Neurotropin for pain with fibromyalgia.

Nishioka M, Fukuda K, Nakamura H, Kato T, Usu C, Arai H, Nishioka K.

Jikei University School of Medicine, Minato-ku, Japan; Jikei

University, Kanagawa, Japan; Juntendo University School of Medicine,

Tokyo, Japan.

Source: Arthritis Rheum 50(9 suppl):S306, abstract 710, 2004.

Abstract: Fibromyalgia (FM) has been characterized by various pain on

muscular-skeletal symptoms with various pathogenic symptoms. As

pathophysiology of FM is not well understood, there has been no

characteristic treatment for FM. We have currently reported that

clinical efficacy of Neurotropin, a non-protein extract from inflamed

skin of rabbits inoculated with vaccinia virus. (H. Nakamura, et al.

Arthritis Research & Therapy 5: S53, 2003.) To confirmed this

preliminary result, we assessed efficiency of Neurotropin 58 cases

with FM 52 cases for female 6 cases for male, mean age 50.4 +/- 15.4

for female and 40.7 +/- 18.9 for male respectively. Treatment of

Neurotropin, 8 ~ 24 units by daily oral administration following 3.6

units by IV and 3.6 units for trigger point injections. Assessment

periods are 8 weeks and biweekly, the following items were evaluated:

- Number of treatment points

- Visual analog scholar

- Face scale by questionnaire of Q.O.L.

Results and Discussion: 31 out of 58 patients (53.4%) improved pain

and 11 patients showed " partially " improved, no change and not

effective were 6 cases (10.3%) and 10 cases (17.2%) respectively.

72.4% of the subjects gained clinical efficacy by VAS assessment and

no cases showed advanced reaction. A concurrent study by Kato revealed

the potential efficacy of Neurotropin on SARD rats, one of the FM

animal models (unpublished). Although further crucial clinical

evaluation is required, Neurotropin appears to be one potential

candidate on the front line of FM treatment.

April 7, 2006

This sure wasn't my experience. I took it for several years cause the

Doc thought it might help with cognition. No change and not change when

I stopped it.

Gail

katrinanon wrote: