Organic Acid Profile

[Guest guest]

The Great Plains Laboratory just sent me a copy of my 24 hour urine

test results.

Comments from anyone, esp. Rich, welcome. Reference range is in

parens.

From what they said in the comments section, glutathione

depletion/deficiency is what is going on. Also low on vitamin C, that

I can take. I have been on Immune Pro and Goatien for some time, and

did three bottles of Liposomal GSH, took a break, am doing some more

now. Doesn't seem to do me much good. The high kynurenic acid is a

tryptophan metabolite and I take tryptophan at night, so that

probably explains that.

Helen

Organic Acid Profile

Great Plains Laboratory

Yeast/Fungal

Citramalic 0.31 (0.0 –2.0)

5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

3-oxoglutaric 0.0 (0.0 –0.5)

furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

furancarbonlglycine 0.52 (0.0 – 60.0)

tartaric 0.35 (0.0 – 16.0)

arabinose 45.21 (0.0 – 47.0)

Bacterial

2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

VMA analog 0.39 (0.0 – 31.0)

Glycolysis

Lactic 1.39 (0.0 – 100.00)

Pyruvic 0.91 (0.0 – 50.0)

2-hydroxybutyric 1.22 (0.0 – 2.0)

glyceric 0.67 (0.0 – 10.0)

Krebs Cycle

Succinic 2.02 (0.0 – 20.0)

Fumaric 0.10 (0.0 – 10.0)

2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

aconitic 6.12 (0.0 – 25.0)

citric 810.56 (180.0- 560.0) HIGH

Amino Acid Metabolites

2-hydroxyisovaleric 0.00 (0.0 – 2.0)

2-oxoisovaleric 0.00 (0.0 – 2.0)

3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

hydroxyisocaproic 0.14 (0.0 – 2.0)

2-oxoisocaproic 0.10 (0.0 – 2.0)

2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

mandelic 0.00 (0.0 – 5.0)

phenyllactic 0.16 (0.0 – 2.0)

phenylpyruvic 2.38 (0.0 – 5.0)

homogentisic 0.18 (0.0 – 2.0)

4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

3-indoleacetic 0.79 (0.0 – 10.0)

Neurotransmitters

HVA 0.89 (0.0 – 3.5)

VMA 2.92 (0.0 – 3.5)

5-hydroxyindoleacetic 1.26 (0.0 –20.0)

Pyrimidines

Uracil 2.24 (0.0 – 22.0)

Thymine 0.35 (0.0 – 2.0)

Fatty Acid Metabolites

3-hydroxybutyric 0.69 (0.0 – 10.0)

acetoacetic 0.89 (0.0 – 10.0)

ethylmalonic 1.36 (0.0 – 10.0)

methylsuccinic 0.58 (0.0 – 5.0)

adipic 0.39 (0.0 – 12.0)

suberic 1.77 (0.0 – 2.0)

sebacic 0.09 (0.0 – 2.0)

Toxic Indicators

Pyroglutamic 4.86 (20.0 – 115.0) LOW

Orotic 0.22 (0.0 – 3.5)

Hydroxyhippuric 0.76 (0.0 – 20.0)

Vitamin Indicators

Methylmalonic 0.82 (0.0 – 5.0)

Ascorbic 4.61 (10.0 – 200.0)

Kynurenic 4.91 (0.0 – 2.0) HIGH

Methylcitric 0.17 (0.0 – 12.0)

Pyridoxic 2.34 (2.0 – 26.0)

Pantothenic 7.03 (1.0 – 4.0) HIGH

Miscellaneous

Glutaric 0.22 (0.0- 2.0)

N-acetyl aspartic 0.00 (0.0 – 100.0)

3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

glycolic 0.74 (0.0 – 100.0)

oxalic 44.91 (0.0 – 100.)

malonic 0.57 (0.0 – 10.0)

methylglutaric 0.32 (0.0 – 10.0)

hippuric 194.57 (10.0 – 400.0)

4-hydroxybutyric 0.77 (0.0 – 5.0)

phenylcarboxylic 0.81 (0.0 – 15.0)

indole-like compound 5.30 (0.0 – 60.0)

[Guest guest]

Hi, Helen.

Your results are very characteristic of glutathione depletion,

showing up both in your skeletal muscle cells and in your kidneys.

The high citric and low 2-oxo-glutaric acids, together with the

other Krebs metabolites being on the low end of normal says that

there is a partial blockade in your Krebs cycle just beyond citric

acid. It is building up in front of the blockade, and the

metabolites beyond the blockade are all low. Glutathione depletion

gives rise to elevation of superoxide and probably peroxynitrite as

well, and both are able to react with aconitase and lower its

activity. This can explain those results. Since the skeletal

muscle cells represent a large fraction of the body's cellular mass,

and the urine carries metabolites from all the cells, it is likely

that these results reflect what is going on in the skeletal muscle

cells, especially if you have physical fatigue, which would be

consistent with this.

In addition, you have low pyroglutamic acid. In the urine this

primarily reflects what is going on in the kidneys, since the

kidneys are the main organ that carries on the gammaglutamyl cycle,

in which pyroglutamic acid is produced from glutathione. The fact

that your pyroglutamic acid is low shows that your kidneys are

depleted in glutathione as well.

I have not seen a more clearcut case before.

With your arabinose as high as it is, I suspect that you have a

yeast infection. This is consistent with having low glutathione,

because glutathione is needed to support cell-mediated immunity,

which is necessary to defeat yeast infections.

It looks as though your ascorbic acid is low, too, although it

doesn't say " LOW " next to it (however, you did say that it is low,

so I'm guessing that you typed the numbers correctly and just left

out the " LOW " ). With as low a glutathione level as you appear to

have, I am not surprised that ascorbate (vitamin C) is also very

low, because when glutathione is badly depleted, there is not enough

available to recycle the vitamin C, and it goes down, too. Note

that glutathione is at the basis of the entire antioxidant enzyme

system in the body. It appears that your body is in a fairly severe

state of oxidative stress.

The elevated kynurenic acid suggests that your body is low in the

active form of vitamin B6, which is P5P. This could be because you

are low in B6, or it could be that your body is not able to convert

B6 to the active form, P5P, very well.

It's possible that this latter problem is what's responsible for

your low glutathione as well, because P5P is important as a coenzyme

for enzymes in the transsulfuration pathway, which produce cysteine,

which is the rate-limiting amino acid for making glutathione.

I don't know why your pantothenic acid (vitamin B5) is high, unless

you are taking a lot of it as a supplement.

I would suggest that you try taking some P5P. Start low, and work

up to say, 30 mg, and observe whether you experience improvement in

your symptoms.

Rich

>

> The Great Plains Laboratory just sent me a copy of my 24 hour

urine

> test results.

>

> Comments from anyone, esp. Rich, welcome. Reference range is in

> parens.

>

> From what they said in the comments section, glutathione

> depletion/deficiency is what is going on. Also low on vitamin C,

that

> I can take. I have been on Immune Pro and Goatien for some time,

and

> did three bottles of Liposomal GSH, took a break, am doing some

more

> now. Doesn't seem to do me much good. The high kynurenic acid is a

> tryptophan metabolite and I take tryptophan at night, so that

> probably explains that.

>

> Helen

>

> Organic Acid Profile

>

> Great Plains Laboratory

>

> Yeast/Fungal

>

> Citramalic 0.31 (0.0 –2.0)

> 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> 3-oxoglutaric 0.0 (0.0 –0.5)

> furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> furancarbonlglycine 0.52 (0.0 – 60.0)

> tartaric 0.35 (0.0 – 16.0)

> arabinose 45.21 (0.0 – 47.0)

>

> Bacterial

>

> 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> VMA analog 0.39 (0.0 – 31.0)

>

> Glycolysis

>

> Lactic 1.39 (0.0 – 100.00)

> Pyruvic 0.91 (0.0 – 50.0)

> 2-hydroxybutyric 1.22 (0.0 – 2.0)

> glyceric 0.67 (0.0 – 10.0)

>

> Krebs Cycle

>

> Succinic 2.02 (0.0 – 20.0)

> Fumaric 0.10 (0.0 – 10.0)

> 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> aconitic 6.12 (0.0 – 25.0)

> citric 810.56 (180.0- 560.0) HIGH

>

> Amino Acid Metabolites

>

> 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> 2-oxoisovaleric 0.00 (0.0 – 2.0)

> 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> hydroxyisocaproic 0.14 (0.0 – 2.0)

> 2-oxoisocaproic 0.10 (0.0 – 2.0)

> 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> mandelic 0.00 (0.0 – 5.0)

> phenyllactic 0.16 (0.0 – 2.0)

> phenylpyruvic 2.38 (0.0 – 5.0)

> homogentisic 0.18 (0.0 – 2.0)

> 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> 3-indoleacetic 0.79 (0.0 – 10.0)

>

> Neurotransmitters

>

> HVA 0.89 (0.0 – 3.5)

> VMA 2.92 (0.0 – 3.5)

> 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

>

> Pyrimidines

>

> Uracil 2.24 (0.0 – 22.0)

> Thymine 0.35 (0.0 – 2.0)

>

> Fatty Acid Metabolites

>

> 3-hydroxybutyric 0.69 (0.0 – 10.0)

> acetoacetic 0.89 (0.0 – 10.0)

> ethylmalonic 1.36 (0.0 – 10.0)

> methylsuccinic 0.58 (0.0 – 5.0)

> adipic 0.39 (0.0 – 12.0)

> suberic 1.77 (0.0 – 2.0)

> sebacic 0.09 (0.0 – 2.0)

>

> Toxic Indicators

>

> Pyroglutamic 4.86 (20.0 – 115.0) LOW

> Orotic 0.22 (0.0 – 3.5)

> Hydroxyhippuric 0.76 (0.0 – 20.0)

>

> Vitamin Indicators

>

> Methylmalonic 0.82 (0.0 – 5.0)

> Ascorbic 4.61 (10.0 – 200.0)

> Kynurenic 4.91 (0.0 – 2.0) HIGH

> Methylcitric 0.17 (0.0 – 12.0)

> Pyridoxic 2.34 (2.0 – 26.0)

> Pantothenic 7.03 (1.0 – 4.0) HIGH

>

> Miscellaneous

>

> Glutaric 0.22 (0.0- 2.0)

> N-acetyl aspartic 0.00 (0.0 – 100.0)

> 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> glycolic 0.74 (0.0 – 100.0)

> oxalic 44.91 (0.0 – 100.)

> malonic 0.57 (0.0 – 10.0)

> methylglutaric 0.32 (0.0 – 10.0)

> hippuric 194.57 (10.0 – 400.0)

> 4-hydroxybutyric 0.77 (0.0 – 5.0)

> phenylcarboxylic 0.81 (0.0 – 15.0)

> indole-like compound 5.30 (0.0 – 60.0)

>

[Guest guest]

Hi, Helen.

I forgot to mention, make sure you take magnesium with the P5P.

About 300 mg should be enough, but more is fine if you are already

taking more. I know that mjh would have gotten me for this! :-)

Rich

> >

> > The Great Plains Laboratory just sent me a copy of my 24 hour

> urine

> > test results.

> >

> > Comments from anyone, esp. Rich, welcome. Reference range is in

> > parens.

> >

> > From what they said in the comments section, glutathione

> > depletion/deficiency is what is going on. Also low on vitamin C,

> that

> > I can take. I have been on Immune Pro and Goatien for some time,

> and

> > did three bottles of Liposomal GSH, took a break, am doing some

> more

> > now. Doesn't seem to do me much good. The high kynurenic acid is

a

> > tryptophan metabolite and I take tryptophan at night, so that

> > probably explains that.

> >

> > Helen

> >

> > Organic Acid Profile

> >

> > Great Plains Laboratory

> >

> > Yeast/Fungal

> >

> > Citramalic 0.31 (0.0 –2.0)

> > 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> > 3-oxoglutaric 0.0 (0.0 –0.5)

> > furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> > furancarbonlglycine 0.52 (0.0 – 60.0)

> > tartaric 0.35 (0.0 – 16.0)

> > arabinose 45.21 (0.0 – 47.0)

> >

> > Bacterial

> >

> > 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> > 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> > HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> > VMA analog 0.39 (0.0 – 31.0)

> >

> > Glycolysis

> >

> > Lactic 1.39 (0.0 – 100.00)

> > Pyruvic 0.91 (0.0 – 50.0)

> > 2-hydroxybutyric 1.22 (0.0 – 2.0)

> > glyceric 0.67 (0.0 – 10.0)

> >

> > Krebs Cycle

> >

> > Succinic 2.02 (0.0 – 20.0)

> > Fumaric 0.10 (0.0 – 10.0)

> > 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> > aconitic 6.12 (0.0 – 25.0)

> > citric 810.56 (180.0- 560.0) HIGH

> >

> > Amino Acid Metabolites

> >

> > 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> > 2-oxoisovaleric 0.00 (0.0 – 2.0)

> > 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> > hydroxyisocaproic 0.14 (0.0 – 2.0)

> > 2-oxoisocaproic 0.10 (0.0 – 2.0)

> > 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> > mandelic 0.00 (0.0 – 5.0)

> > phenyllactic 0.16 (0.0 – 2.0)

> > phenylpyruvic 2.38 (0.0 – 5.0)

> > homogentisic 0.18 (0.0 – 2.0)

> > 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> > 3-indoleacetic 0.79 (0.0 – 10.0)

> >

> > Neurotransmitters

> >

> > HVA 0.89 (0.0 – 3.5)

> > VMA 2.92 (0.0 – 3.5)

> > 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

> >

> > Pyrimidines

> >

> > Uracil 2.24 (0.0 – 22.0)

> > Thymine 0.35 (0.0 – 2.0)

> >

> > Fatty Acid Metabolites

> >

> > 3-hydroxybutyric 0.69 (0.0 – 10.0)

> > acetoacetic 0.89 (0.0 – 10.0)

> > ethylmalonic 1.36 (0.0 – 10.0)

> > methylsuccinic 0.58 (0.0 – 5.0)

> > adipic 0.39 (0.0 – 12.0)

> > suberic 1.77 (0.0 – 2.0)

> > sebacic 0.09 (0.0 – 2.0)

> >

> > Toxic Indicators

> >

> > Pyroglutamic 4.86 (20.0 – 115.0) LOW

> > Orotic 0.22 (0.0 – 3.5)

> > Hydroxyhippuric 0.76 (0.0 – 20.0)

> >

> > Vitamin Indicators

> >

> > Methylmalonic 0.82 (0.0 – 5.0)

> > Ascorbic 4.61 (10.0 – 200.0)

> > Kynurenic 4.91 (0.0 – 2.0) HIGH

> > Methylcitric 0.17 (0.0 – 12.0)

> > Pyridoxic 2.34 (2.0 – 26.0)

> > Pantothenic 7.03 (1.0 – 4.0) HIGH

> >

> > Miscellaneous

> >

> > Glutaric 0.22 (0.0- 2.0)

> > N-acetyl aspartic 0.00 (0.0 – 100.0)

> > 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> > glycolic 0.74 (0.0 – 100.0)

> > oxalic 44.91 (0.0 – 100.)

> > malonic 0.57 (0.0 – 10.0)

> > methylglutaric 0.32 (0.0 – 10.0)

> > hippuric 194.57 (10.0 – 400.0)

> > 4-hydroxybutyric 0.77 (0.0 – 5.0)

> > phenylcarboxylic 0.81 (0.0 – 15.0)

> > indole-like compound 5.30 (0.0 – 60.0)

> >

>