Rich/hormones processed thru methylation/sulfation pathways?

[Guest guest]

Are hormones, whether endogenous or exogenous, processed thru either

the methylation or sulfation pathways? If so, then if someone has a

block in either pathway, then the hormone will not be utlized by the

body?

Would transdermal creams, or injections, be subject to this same

processing? (if hormones that are produced within the body go thru

these pathways, then I would guess these forms would also?)

Bottom line: if someone has a block in these pathways, then would any

hormone, no matter its source, not going to be utilized by the body?

Thanks for any thoughts on this. Les

[Guest guest]

Hi, Les.

As far as I know, there is no interaction between most of the hormones

and the methylation or transsulfation pathways. These pathways

involve sulfur-containing substances. I know of one hormone that

contains sulfur in the form of cysteine, and that is secretin. I

suppose that if the methylation cycle were blocked and there was a

shortage of cysteine, it could conceivably impact the production of

secretin. I suppose that when secretin is broken down, that some of

the cysteine might go through the sulfoxidation pathway, but that

would not interfere with the function of secretin. Generally

speaking, though, I don't think there would be a problem of the sort

you have asked about.

Rich

>

> Are hormones, whether endogenous or exogenous, processed thru either

> the methylation or sulfation pathways? If so, then if someone has a

> block in either pathway, then the hormone will not be utlized by the

> body?

> Would transdermal creams, or injections, be subject to this same

> processing? (if hormones that are produced within the body go thru

> these pathways, then I would guess these forms would also?)

> Bottom line: if someone has a block in these pathways, then would

any

> hormone, no matter its source, not going to be utilized by the body?

> Thanks for any thoughts on this. Les

>

[Guest guest]

>

> Are hormones, whether endogenous or exogenous, processed thru either

> the methylation or sulfation pathways?

Thyroid and some steroids are sulfated.

Catecholamines (which are kinda like hormones in the body) are

methylated as well as oxidized.

> If so, then if someone has a

> block in either pathway, then the hormone will not be utlized by the

> body?

> Would transdermal creams, or injections, be subject to this same

> processing?

Yes.

>(if hormones that are produced within the body go thru

> these pathways, then I would guess these forms would also?)

> Bottom line: if someone has a block in these pathways, then would any

> hormone, no matter its source, not going to be utilized by the body?

Mostly these reactions INACTIVATE the hormones.

E. g. women who don't sulfate things well get breast pain from modest

amounts of DHEA.

> Thanks for any thoughts on this. Les

>

[Guest guest]

Boy . . . this sounds like me . . . Could this be what is going on with the

Progesterone, too? I can not handle the DHEA . .kts of breast pain and bloating.

Thanks, Sue T

andrewhallcutler <AndyCutler@...> wrote:

E. g. women who don't sulfate things well get breast pain from modest

amounts of DHEA.

[Guest guest]

Thank you for your response. I would suppose, then, as you have implied, that

if these pathways are involved with inactivating these substances, then that in

itself could cause symptoms, esp with low dosages.

If catecholamines (which I think are produced by the adrenals? And by some

aminos?) are inactivated by the methylation pathway, then one would tend to

become very 'hyped' with just a low amount of these in the system ( wonder if

this also applies to amino acids that are excitory?)

If there is no way to introduce these substances to the body without having them

subjected to a faulty pathway, and thus not having a 'normal' effect, then seems

we are SOL until those pathways are fixed? (or until we can determine what our

individual dose should be, given the malfunctioning pathway). thanks - Les

Re: Rich/hormones processed thru

methylation/sulfation pathways?

>

> Are hormones, whether endogenous or exogenous, processed thru either

> the methylation or sulfation pathways?

Thyroid and some steroids are sulfated.

Catecholamines (which are kinda like hormones in the body) are

methylated as well as oxidized.

> If so, then if someone has a

> block in either pathway, then the hormone will not be utlized by the

> body?

> Would transdermal creams, or injections, be subject to this same

> processing?

Yes.

>(if hormones that are produced within the body go thru

> these pathways, then I would guess these forms would also?)

> Bottom line: if someone has a block in these pathways, then would any

> hormone, no matter its source, not going to be utilized by the body?

Mostly these reactions INACTIVATE the hormones.

E. g. women who don't sulfate things well get breast pain from modest

amounts of DHEA.

> Thanks for any thoughts on this. Les

>

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Rich - thank you very much for your insight! (my methylation cycle IS blocked,

and I DO have a shortage of cysteine, so then I suppose I could have a shortage

of secretin? I believe this is involved with digestion and absorption? Two big

problems for me, as with many of us-)

Re: Rich/hormones processed thru

methylation/sulfation pathways?

Hi, Les.

As far as I know, there is no interaction between most of the hormones

and the methylation or transsulfation pathways. These pathways

involve sulfur-containing substances. I know of one hormone that

contains sulfur in the form of cysteine, and that is secretin. I

suppose that if the methylation cycle were blocked and there was a

shortage of cysteine, it could conceivably impact the production of

secretin. I suppose that when secretin is broken down, that some of

the cysteine might go through the sulfoxidation pathway, but that

would not interfere with the function of secretin. Generally

speaking, though, I don't think there would be a problem of the sort

you have asked about.

Rich

>

> Are hormones, whether endogenous or exogenous, processed thru either

> the methylation or sulfation pathways? If so, then if someone has a

> block in either pathway, then the hormone will not be utlized by the

> body?

> Would transdermal creams, or injections, be subject to this same

> processing? (if hormones that are produced within the body go thru

> these pathways, then I would guess these forms would also?)

> Bottom line: if someone has a block in these pathways, then would

any

> hormone, no matter its source, not going to be utilized by the body?

> Thanks for any thoughts on this. Les

>

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Hi, .

This might be a possibility, but I think that the problems with

hormone levels result from problems back at the hypothalamus, which

controls the amount of various hormones that are secreted. I

suspect that this is due to oxidative stress in the hypothalamus, as

a result of glutathione depletion there. In the disorders Dr.

Schaller mentioned as causing low hormone levels, I suspect that the

hypothalamus is affected also, but perhaps by a different

mechanism. Dr. Shoemaker has talked about cytokines acting to block

receptors on the hypothalamus, and that may account for this.

So, yes, downstream effects on hormones are certainly a possibility,

but I think I would look first at whether enough is being secreted

in the first place.

If your methylation cycle is blocked and you are low in cysteine, I

expect that you are also low in glutathione, and thus are in a state

of oxidative stress. This could be impacting your hypothalamus and

lowering the output of several hormones.

Rich

Rich

> >

> > Are hormones, whether endogenous or exogenous, processed thru

either

> > the methylation or sulfation pathways? If so, then if someone

has a

> > block in either pathway, then the hormone will not be utlized

by the

> > body?

> > Would transdermal creams, or injections, be subject to this

same

> > processing? (if hormones that are produced within the body go

thru

> > these pathways, then I would guess these forms would also?)

> > Bottom line: if someone has a block in these pathways, then

would

> any

> > hormone, no matter its source, not going to be utilized by

the body?

> > Thanks for any thoughts on this. Les

> >

>

>

>

>

>

>

>

> This list is intended for patients to share personal experiences

with each other, not to give medical advice. If you are interested

in any treatment discussed here, please consult your doctor.

>

>

>

>

[Guest guest]

Thank you for this insight, Rich! I never would have made the connection between

oxidative stress, the hypothalamus, glutathione depletion, and the resulting

lowered output of hormones (and yes, I do have a methylation block and am very

low in cysteine, even tho I am supplementing). Les

Re: Rich/hormones processed thru

methylation/sulfation pathways?

Hi, .

This might be a possibility, but I think that the problems with

hormone levels result from problems back at the hypothalamus, which

controls the amount of various hormones that are secreted. I

suspect that this is due to oxidative stress in the hypothalamus, as

a result of glutathione depletion there. In the disorders Dr.

Schaller mentioned as causing low hormone levels, I suspect that the

hypothalamus is affected also, but perhaps by a different

mechanism. Dr. Shoemaker has talked about cytokines acting to block

receptors on the hypothalamus, and that may account for this.

So, yes, downstream effects on hormones are certainly a possibility,

but I think I would look first at whether enough is being secreted

in the first place.

If your methylation cycle is blocked and you are low in cysteine, I

expect that you are also low in glutathione, and thus are in a state

of oxidative stress. This could be impacting your hypothalamus and

lowering the output of several hormones.

Rich

Rich

> >

> > Are hormones, whether endogenous or exogenous, processed thru

either

> > the methylation or sulfation pathways? If so, then if someone

has a

> > block in either pathway, then the hormone will not be utlized

by the

> > body?

> > Would transdermal creams, or injections, be subject to this

same

> > processing? (if hormones that are produced within the body go

thru

> > these pathways, then I would guess these forms would also?)

> > Bottom line: if someone has a block in these pathways, then

would

> any

> > hormone, no matter its source, not going to be utilized by

the body?

> > Thanks for any thoughts on this. Les

> >

>

>

>

>

>

>

>

> This list is intended for patients to share personal experiences

with each other, not to give medical advice. If you are interested

in any treatment discussed here, please consult your doctor.

>

>

>

>