S.'s case, was: Re: Rich, Kathy: Glutathione buiding and Phase 2 Detox

[Guest guest]

Hi, S.

Thanks for the response. My comments are at the asterisks below:

>

> Hi Rich,

>

> Thanks for your response, it was very helpful. I don't think my

> problem is lack of protein or digestion issues. I've been on a

high

> protein diet, with no GI problems at all.

***I'm glad to hear that you have no G.I. problems. That can be a

big issue for many PWCs.

(Total protein is 6.3,

> albumin 3.8)

***Those blood protein numbers are within the normal ranges, but on

the low end. The (relatively tight) normal ranges I use, based on

Frances Fischbach, A Manual of Laboratory & Diagnostic Tests, Sixth

Edition, p. 620, are 6.0 to 8.0 g/dl for total protein, and 3.8 to

5.0 g/dl for albumin. So this suggests that you are in fact low in

protein.

My guess is it's the kidneys wasting sulfate secondary

> to mercury. I'll talk to Vrchota about a 24-hour sulfate test.

***Good. I think that would be a helpful test to run. It's

possible that the mercury is doing this, but see below about the

protein situation.

I'm

> starting to work on getting my amalgams replaced; it's going to

take

> a while, probably a year. The MD that's going to detox the

mercury

> wants me to come in for a vitamin C flush (35 grams) immediately

> following my dental appointments.

***I would suggest holding off on that until your sulfur metabolism

is in better shape and your glutathione level has been restored.

Otherwise, the mercury that is released as vapor and inhaled when

the amalgams are heated by the drilling will not be bound and

carried out of your body by glutathione, and this could make you

much sicker. I have heard many stories from PWCs who have been

through this, and suffered setbacks that took them months to years

to get over. Even when a dentist uses precautions such as a high

volume vacuum line, a dam, and lots of water cooling, it seems that

enough mercury is still inhaled to raise the mercury toxicity in

many PWCs, and the brain seems to receive enough of it to give them

neurological symptoms.

>

> I am addressing the detox issues by trying to (1) avoid

> environmental toxic sources and (2) decreasing my total load.

> Vrchota thought Ultra- Clear would help with that. After studying

> the protocol I've decided to adapt some of the principals but not

> institute it fully. It's really structured as an elimination diet

> for food allergies, which I don't think are an issue for me.

***Avoiding environmental toxins is very important in your case, in

my opinion. I agree on not doing the Ultra-Clear. I think the

focus needs to be on getting your sulfur metabolism back up to par.

>

> I'm using a powdered soy protein as my main source of protein

> (eliminating beef, which is easy for me to do, still eating a

little

> turkey, chicken, salmon) - total protein intake is about 30 grams

a

> day.

***I'm guessing that you have chosen soy protein to eliminate toxins

that may be found in beef. However, soy protein carries some other

problems. One is that (unless it's fermented, as the Asians learned

to do a long time ago, probably mainly to prevent spoilage, but it

turns out to have an important other benefit) it contains substances

that block the enzyme trypsin in the human digestive tract, and

thereby interfere with the absorption of amino acids from the

protein. Another is that soy contains considerable phytate, and

that binds minerals and prevents their absorption as well. One

theory for why the Japanese people are smaller in Japan than their

kids are when they move to the U.S. is that their diets are lower in

soy here, so that they are able to absorb more protein and more

minerals.

***Another issue with soy protein in the current context is that it,

like plant-based protein in general, is not very high in the sulfur-

containing amino acids methionine and cysteine. Since you are able

to tolerate whey protein well, I would suggest that you switch to

whey protein instead of soy protein. It doesn't have to be the more

expensive types of whey protein isolates or concentrates for use as

a bulk protein source for the diet, although including some RenewPro

would be a good idea, because that is especially high in cysteine,

which will help to build glutathione in the liver.

***The Cecil Textbook of Medicine, 22nd Edition (2004), p. 1308,

says, " Recommended protein intake is 0.8 g per kg of body weight per

day for healthy adults, with essential amino acids contributing a

relatively small proportion of this total amount. " I don't know

what your body weight is, but unless you weigh less than 83 pounds,

I would say that you could use some more protein.

> I've also cut back on my dairy intake which comes mostly in the

form

> of cheese

***Cheese is made from butterfat and casein, and it isn't very high

in sulfur-containing amino acids, which are mainly in the whey

fraction of the milk.

, am increasing veggies (I'm not a big fan of cruciferous

> vegetables which seems to be recommended to help with each of

these

> SNP's)

***I think that's unfortunate, because the cruciferous vegetables

are high in sulfur-containing compounds, and you appear to be low in

sulfur.

, am going to start DIM (diinodoylmethane),

***I think that should be helpful.

and have cut out

> my daily cup of decaf coffee.

***O.K. That's probably a good idea, though a sacrifice!

> I'm just on oral ceftin 500 mg BID now for antibiotics so I'm

hoping

> that helps also

***I think it will. I don't think ceftin requires CYP450 enzymes

for its detox.

and am using my sauna almost nightly to induce a

> good sweat.

***O.K. Make sure that you supplement minerals, because you can

lose quite a bit of magnesium, zinc and selenium in the sauna. When

you combine that with the phytate in soy, you could go low in

several minerals unless you supplement them.

> I've increased CSM to 3X daily using a scoop of Renew Life Fiber

> Smart with each dose (it also contains probiotics).

***O.K. That should help to get rid of the anionic (negatively

charged) toxins in your enterohepatic circulation. It will pull

down your cholesterol, too.

>

> I don't understand the mechanism of action of the B6 and why it

made

> me feel so bad. Did it mobilize toxins that I then could not

> effectively detox?

***I suspect that it further depleted the sulfur metabolites in your

methylation cycle by speeding up your transsulfuration pathway.

Sorry about that. I didn't realize that your homocysteine was low

when I suggested that. I should have waited for that information.

>

> Genovations should be sending you my full report.

***Thanks very much.

It's mostly pages

> of medications I need to avoid. It'll be best if I avoid the OR

at

> all costs!!

***Yes, I hope you can avoid it, too. Based on your Detoxigenomics

Profile, you really aren't genetically equipped to do a lot of heavy

detoxing of anesthetics or other pharmaceuticals.

***In view of the above discussion, I do think that you may not be

getting enough of the sulfur-containing amino acids in your diet,

and that may be responsible for at least part of the depletion of

sulfur metabolites in your body. It's also possible that mercury is

contributing by blocking the sulfate transporters in your kidneys.

It might be interesting to maintain your current diet until you are

able to do a 24-hour urine collection to measure sulfate, if Dr.

Vrchota agrees. That way, we can have a consistent picture to

analyze. If you switch protein intake now, a sulfate analysis done

later would not correspond to the other measurements you already

have. I would recommend doing the urine sulfate analysis soon,

though, so that you will not have to delay raising your intake of

sulfur-containing amino acids.

>

> Thanks much,

>

***Again, I hope this turns out to be helpful, though I realize that

some of it might be kind of chagrining.

Rich