Re: Dr. Tim Guilford's new products

[Guest guest]

>

> Hi, all.

>

> Al mentioned a new liposomal glutathione product called

> " Readisorb. "

> Rich

How would this product differ from Renewpro from Needs?

Ballady

[Guest guest]

Hi, Ballady.

These two products represent two approaches to raising glutathione

in the body. The Readisorb and similar products bring glutathione

directly into the cells of the body in its completed form. RenewPro

and other whey protein based products supply the amino acids needed

for the body to make its own glutathione, which the cells do

normally.

Readisorb (or Lipoceutical Glutathione) and the other liposomal

glutathione products (Essential GSH and LipoFlow Glutathione)

contain actual chemically reduced glutathione (a tripeptide made up

of the amino acids glutamic acid, cysteine and glycine) contained

inside microscopic capsules made of soy-based phospholipids, called

liposomes, which are in a water-based suspension with a slightly

acidic pH. The actual glutathione comes from yeasts, and is

produced primarily by a company in Japan. When one of these

products is taken orally, it is thought that these liposomes are

absorbed by the cells lining the stomach by a process called

endocytosis. The phospholipid capsules are made from similar

material as are the phospholipid membranes that surround our cells,

so they merge with the cell membranes and are taken inside the cells

without the glutathione being broken down. Some of the liposomes

apparently pass on through the cells into the bloodstream and are

carried throughout the body and can enter other types of cells by

the same mechanism, including crossing the blood-brain barrier and

entering cells in the brain. This is sort of like a Trojan horse

concept for getting actual glutathione into the cells of the body.

This approach was originally pioneered by the drug industry to move

drugs into the body, but in recent years it has spread to becoming a

means of getting certain natural substances such as glutathione into

cells as well. This approach is particularly used for substances

that would otherwise be broken down in the gut during the digestive

process, which most actual glutathione is in the human gut.

RenewPro, on the other hand, is made from raw cows' milk by

separation and ultrafiltration processes that separate the whey

protein, peptides, lactoferrin and immunoglobulins from the other

components of milk, including the casein (proteins found in

the " curd " fraction), butterfat, and lactose, and dry them to a

powder. This is done by low-temperature processes that do not

change the structure of the proteins. That is, they remain as

native or nondenatured proteins. This is important, because whey

protein is rich in cysteine, which is the rate-limiting amino acid

for making glutathione in the body, and it is easily oxidized by

processing. Other common whey protein products, including the so-

called undenatured whey protein isolates, are byproducts of

cheesemaking, in which the milk is pasteurized and acid-treated to

separate out the curd fraction for use in making the cheese. What

is left over used to be thrown away, but since the late 1980s is

processed to extract the whey protein for sale, but the heating and

acidification modifies the original structure of the proteins and

actually destroys some of them. One of the most important aspects

of this is that the cysteine is oxidized to become cystine in these

processes. That is significant, because normally in the body, the

main producer of glutathione is the liver. However, the liver cells

do not import cystine very well, preferring cysteine. So if one of

these pasteurized/acid-treated whey protein products is taken, the

cystine is absorbed primarily by the kidneys, and some of it is

processed in the kidneys to make cysteine, which is put back into

the blood. The liver cells then import some of this cysteine, and

then are able to make glutathione, but by a slower and more

roundabout way. Some PWCs find the nondenatured products to be

preferable, and some find that they are too potent, and they prefer

the ones based on pasteurization. Both will help the body to make

glutathione.

If the digestive system is not working well, the liposomal approach

may work better for getting glutathione into the cells. However, it

is also more expensive. Some of the liposomal products offer the

additional advantage of supplying readily usable lipoproteins to the

cells as well as glutathione. The makers of Essential GSH and

LipoFlow Glutathione claim that their lipoproteins are more usable

that the hydroxylated lipoproteins used in Readisorb (Lipoceutical

Glutathione). I don't know of any direct comparison studies that

test that claim. I don't think there are any studies available,

either, that do a direct comparison between the effectiveness of the

two types of approaches for raising glutathione. There is more

experience among people on the list with the whey protein products,

because they have been used longer, since about 1998 in CFS. The

first liposomal glutathione product was only introduced in the last

year or two. The main market for the liposomal glutathiones has

been autism patients, I believe, though it is used by others as

well, including cystic fibrosis patients, some with Parkinson's

disease, and also PWCs.

Over the past few months, I have become convinced that in many PWCs

it will be necessary to get the sulfur metabolism (including the

methylation cycle) running properly before glutathione can be raised

back to normal levels. This was discovered and published in autism

by S. Jill and coworkers about a year and a half ago. It

appears that the same biochemical issues are at play in many PWCs.

So while some PWCs can raise their glutathione levels by use of one

or the other of the above types of approaches, others must work on

their methylation cycles using other supplements first. We are in

the early stages of testing this idea now, and a few people on the

list are trying it.

Rich

> >

> > Hi, all.

> >

> > Al mentioned a new liposomal glutathione product called

> > " Readisorb. "

> > Rich

>

> How would this product differ from Renewpro from Needs?

> Ballady

>

[Guest guest]

Rich,

Thank you so much for this thorough explanation. I'm not sure I

understand all of it, but I certainly appreciate it. I was planning to

order Renewpro today so your response came just in time.

Now I'm not sure if I should order it or address the issue you raise

about sulfur metabolism and it possibly not running properly. How

would one determine this? And, if this is the case, how exactly would

one go about raising their methylation cycles using other supplements

first, which you suggest.

Thank you again,

Ballady

> > >

> > > Hi, all.

> > >

> > > Al mentioned a new liposomal glutathione product called

> > > " Readisorb. "

> > > Rich

> >

> > How would this product differ from Renewpro from Needs?

> > Ballady

> >

>

[Guest guest]

Wellness took out the glycerin as many folks have problems with it...

>

> Hi, all.

>

> Al mentioned a new liposomal glutathione product called

> " Readisorb. " I checked it out on the web, and it is none other than

> Lipoceutical Glutathione with a different label! It appears that

> Dr. Tim Guilford has renamed his company " Your Energy Systems, LLC, "

> from its old name " Wellness Products, " now that Wellness Health

> Pharmacy has introduced its own liposomal glutathione product,

> called Essential GSH.

>

> Dr. Guilford is still selling his liposomal glutathione product at

> www.gshnow.com on a retail basis as Lipoceutical Glutathione, with

> the price competitive with the price of Essential GSH, but he has

> also relabled it as Readisorb Liposomal Glutathione, which he is

> selling to licensed healthcare practitioners and selected

> distributors. In addition, he has introduced a liposomal methyl B12

> sublingual spray, and a liposomal melatonin sublingual spray. He is

> advertising the methyl B12 spray as a means to support the

> methylation cycle, and he is advertising the melatonin spray for its

> antioxidant properties.

>

> From the labels of these two new products, it appears that he is

> using the same process to form the liposomes for them as for

> Lipoceutical Glutathione, since they all contain purified water,

> glycerin, hydroxylated soy lecithin, citric acid and potassium

> sorbate.

>

> I think this is an interesting development. Dr. Guilford has

> clearly taken on board the significance of the paper by Jill

> et al., which he cites twice on his webpage, and he is carefully

> implying that sublingual liposomal methyl B12 might be useful for

> the treatment of autism. (Note that makers of supplements can't come

> right out and say that their products can be used to treat diseases,

> or they will get in trouble with the FDA, which holds that that

> makes them drugs, and without FDA approval, drugs cannot be sold.)

> As far as I know, this is the first liposomal methyl B12 on the

> market. He doesn't mention using it for CFS on his webpage, but I

> communicated with him some time back about that, so he is aware of

> my thinking. This product might be an good way for PWCs to take

> methyl B12. I don't know what the cost will be. It probably

> depends on how much markup individual healthcare practitioners will

> give it.

>

> I have no financial interest in these products.

>

> Rich

>