Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Kathy Some folks find that Horsechestnut and Butcher's broom help with the situation you describe below. Also vitamin E. Hawthorne berry, l-Taurine, Magnesium + B6 will support the rest of the cardiovascular system. Hope this helps mjh In a message dated 3/2/06 3:41:51 A.M. Eastern Standard Time, kdpart@... writes: Does anyone know what caused leg tingling, occasional feet burning, freezing legs from knee down, pain levels increasing from walking, recently legs feel weaker standing. I take thyroid, was told was taking too much, take epsom baths, lots of vitamins. Is it a circulation problem or nerve pain, vascular something, heart symptom? Starting to think amputation might help with low blood volume issues. Has anyone taken something which resolved this symptom? I used to think ginko helped but not lately. I guess it's minor as pain goes, but represents increased disability for me. Thanks kathy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Kathy, I have leg and foot tingling and foot burning sensations on reclining for bed. (I think it's what they call restless leg syndrome in my case.) When it gets bad and disrupts my sleep, I take cyclobenzaprine (Flexeril), but usually I try to not take anything. I don't usually have this tingling, foot burning stuff unless I'm lying down. Also have cold legs, feet, hands. I will wear socks till the weather gets really warm here, probably June. I attribute my symptoms to my ruptured L4-5, peripheral neuropathy, impinged nerves, degenerative disk disease, and my relative lack of activity. I'm not sure what pain you are having that is increasing with walking. Is this leg pain or somewhere else in the body? I have periodic leg weakness attributable to atrophied calf muscles, but I don't think that's what you're describing. Can you describe it in any more detail? I also take replacement thyroxine -- 150 micrograms/day. It's hard for me to tell what kind of pain you're having. The coldness could be a circulation problem but I think could be other things too. I'm sort of laying off my vitamins right now, but I do remember that when I take B6 consistently -- or increase OR decrease it, I will get leg cramping at night. I'm afraid that this is all I can help with. Why are you thinking of " amputation, " though? This certainly sounds drastic. Do you have a doctor you can check in with? > > Does anyone know what caused leg tingling, occasional feet burning, freezing legs from knee down, pain levels increasing from walking, recently legs feel weaker standing. I take thyroid, was told was taking too much, take epsom baths, lots of vitamins. Is it a circulation problem or nerve pain, vascular something, heart symptom? Starting to think amputation might help with low blood volume issues. Has anyone taken something which resolved this symptom? I used to think ginko helped but not lately. I guess it's minor as pain goes, but represents increased disability for me. Thanks kathy > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Oh gee, thanks, mjh. So many 2 or 3 or even 4 to tango in these things. You wouldn't happen to know what CBS stands for, would you? I asked earlier and no one answered. I've gone through an acronym finder online, and couldn't find it there either. Thanks, mjh. > > > > > Magnesium helps B6 do it's thing. So, when you resume it, please remember > that it takes the two to tango! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Hi Kathy, I get the same symptoms. This is what helps me. 1. Magnesium injections 2. Baclofen at night if it is really bad 3. " Tonic water " for the Quinene 4. Keeping my legs up as much as I can Hope that this helps. Kindest regards, Annette --------------------------------- Messenger NEW - crystal clear PC to PC calling worldwide with voicemail Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Hi, , mjh and the group. In the current context, CBS stands for cystathionine beta synthase. It's an enzyme that catalyzes a reaction that combines homocysteine with serine to form cystathionine, at the junction between the methylation cycle and the transsulfuration pathway. The cofactor for this enzyme is P5P, the active form of vitamin B6. Its significance for autism, and I believe also for severe cases of CFS, is that one of its possible genetic variations is C699T, which means that in the gene in the person's DNA that codes for this enzyme has a mutation that involves a substitution of thymine for cytosine in the 699th base pair of the DNA. This is called a single nucleotide polymorphism or SNP. The result is that the mutated enzyme that is produced operates its reaction faster than normal. Amy Yasko says this is the worst genetic variation she sees in autism, especially if the person is homozygous for this mutation (that is, they have inherited this same mutation from both their mother and their father, and thus both their copies of the gene for this enzyme have this mutation). When this reaction runs too fast, it drains down the homocysteine into the transsulfuration pathway, and most of the sulfur goes toward making taurine and sulfate instead of glutathione. So glutathione becomes depleted, the methylation cycle becomes depleted, too much ammonia is produced from the breakdown of cystathionine, hydrogen sulfide is produced because the sulfoxidation pathway cannot handle the extra flow. The urea cycle cannot handle the large production of ammonia, so ammonia builds up, and it is a neurotoxin and produces a variety of neurological symptoms. Hydrogen sulfide is also toxic, and produces torpor. The depleted methylation cycle propagates problems into the folate metabolism, and this affects production of new DNA and RNA. This in turn affects the biopterin cycle, which impacts the production of the neurotransmitters serotonin and dopamine. The person goes into oxidative stress, etc., etc. This is a bad one, and the effects of it are worse if the person consumes a lot of protein, because that produces more ammonia and hydrogen sulfide. Rich > > > > > > > > > > Magnesium helps B6 do it's thing. So, when you resume it, please > remember > > that it takes the two to tango! > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Thank you, mjh. CBS in Rich's stuff. I'm wondering if it's just plural of CB (which I also can't figure out!) -- CBS or CBs? > > > > > I haven't the foggiest idea what CBS stands for other than the television > network I am listening to. > > mjh > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 This is really interesting, Annette. I always drank tonic water when I would feel the worst (before I suspected what was wrong with me) and associated it with the quinine in it. I never knew if the quinine in the tonic water actually DID anything or if there was something " real " going on. Do you know what this quinine thing is about? > > Hi Kathy, > > I get the same symptoms. This is what helps me. > > 1. Magnesium injections > 2. Baclofen at night if it is really bad > 3. " Tonic water " for the Quinene > 4. Keeping my legs up as much as I can > > Hope that this helps. > > Kindest regards, > Annette > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Thanks, Rich (for the full response, too). > > Hi, , mjh and the group. > > In the current context, CBS stands for cystathionine beta synthase. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 mjh, it " takes about a liter " of tonic water for you to...what? Deal with leg cramps or something else? I'm a bit confused here...sorry. When I would drink tonic water, attempting to make myself feel better, was when I would be overcome with overall fluish dead-body feeling. I never knew what any significance might be, except that I had a couple of friends, both with lupus, and some of their individual protocols included quinine or a near relative (name escapes me now, sorry). I think what they took was a prescribed Rx. But I thought, at the time, there must be some correlation between some lupus symptoms and what was " wrong " with me. > > > > > Quinine pills are an old time remedy for leg cramps. They are still > available OTC. > > By the way, I always keep a couple of liters of Tonic water on hand. It > takes about a liter for me. > > But, Mg/B6 and vitamin E are the even heavier hitters for me with leg cramps > and the herbs I listed for circulation issues, which also help resolve the > pain, cold and etc. > > mjh > > > In a message dated 3/2/06 1:30:08 P.M. Eastern Standard Time, > kcapel@... writes: > > This is really interesting, Annette. I always drank tonic water when > I would feel the worst (before I suspected what was wrong with me) > and associated it with the quinine in it. I never knew if the > quinine in the tonic water actually DID anything or if there was > something " real " going on. Do you know what this quinine thing is > about? > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2006 Report Share Posted March 2, 2006 Still very helpful, Annette...thank you. The mystery around quinine for me just continues. (And makes me wonder now about any connecion in me between " dancing feet " and " general cruds " in my persistent problems.) > > No sorry, , > > I don't know how the Quinene works. Professor Brostoff (Allergist/Immunologist in London) mentioned it to me as a possible remedy for " restless legs " . > > My Mother had been using it for years with some success. The magnesium injections were the best for me but I've not been able to afford them. > > Kndest regards, > Annette > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 3, 2006 Report Share Posted March 3, 2006 Hi Sara - I would love to hear back from you after your visit with Dr. Dunne. I saw Dr. Saul Pilar (on W 16th) approximately ten years ago. He was the only doctor at the time that my GP could find who treated CFS. My problem with him was everytime he tried a new treatment, if there weren't any clear results in just two weeks, he moved on to something else. I ended up spending a lot of money with no results. I look forward to hearing back from you. Take care. Bernie > Bernie, I'm on the North Shore. I've got an appointment with Dr. > Dunne (he's downtown, on Broadway) early next month. > > My GP asked around, and says this is supposed to be THE guy in > Vancouver for ME right now. > > Have you gone to him? If so, how'd it go? And if you're not familiar > with him, would you like me to report back after my visit? > > Sara > Quote Link to comment Share on other sites More sharing options...
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